A5102784567- HIV Research and Treatment
- Immune Cell Function and Interaction
- Obstructive Sleep Apnea Research
- HIV/AIDS drug development and treatment
- Mosquito-borne diseases and control
- Neuroscience of respiration and sleep
- RNA Interference and Gene Delivery
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Virology and Viral Diseases
- Viral Infections and Vectors
- Sleep and related disorders
- Cystic Fibrosis Research Advances
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sleep and Wakefulness Research
- Single-cell and spatial transcriptomics
- Tracheal and airway disorders
- Lipid Membrane Structure and Behavior
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- T-cell and B-cell Immunology
- Genomics and Phylogenetic Studies
- Neonatal Respiratory Health Research
Nethradhama Superspeciality Eye Hospital
2025
All India Institute of Medical Sciences, Nagpur
2025
Royal Darwin Hospital
2020-2024
Gold Coast Health
2024
Post Graduate Institute of Medical Education and Research
2024
Artemis Hospitals
2015-2022
Institute of Medical Sciences
2021-2022
Texas Tech University Health Sciences Center
2009-2021
Texas Tech University
2009-2021
CSL (United States)
2021
Bronchiectasis is a common but neglected chronic lung disease. Most epidemiological data are limited to cohorts from Europe and the USA, with few low-income middle-income countries. We therefore aimed describe characteristics, severity of disease, microbiology, treatment patients bronchiectasis in India.The Indian registry multicentre, prospective, observational cohort study. Adult (≥18 years) CT-confirmed were enrolled 31 centres across India. Patients due cystic fibrosis or traction...
Abstract Mosquito borne viral diseases are an emerging threat as evident from the recent outbreak of Zika virus (ZIKV) well repeated outbreaks Chikungunya (CHIKV), Yellow fever (YFV) and Japanese encephalitis (JEV) in different geographical regions. These four arboviruses endemic overlapping regions due to co-prevalence transmitting mosquito vector species Aedes Culex . Thus, a multivalent vaccine that targets all viruses would be benefit world where these endemic. We developed potential...
Background Identifying risk factors for poor outcomes can help with stratification and targeting of treatment. Risk mortality exacerbations have been identified in bronchiectasis but almost exclusively studied European North American populations. This study investigated the outcome a large population patients enrolled India. Methods The Multicentre Bronchiectasis Audit Research Collaboration (EMBARC) Respiratory Network India (EMBARC-India) registry is prospective observational adults...
Recent worldwide outbreaks of Zika virus (ZIKV) infection and the lack an approved vaccine raise serious concerns regarding preparedness to combat this emerging virus. We used a virus-like particle (VLP)-based approach develop microneutralization assay for ZIKV. A synthetic capsid-premembrane-envelope (C-prM-E) gene construct ZIKV was generate reporter particles (RVPs) that package green fluorescent protein (GFP) reporter-expressing West Nile (WNV) replicon. The adapted 96-well format,...
Type 2 diabetes mellitus and hypertension overlap in the population. In many subjects, development of mellitusis characterized by a relatively rapid increase plasma glucose values. Whether similar phenomenon occurs duringthe is not known. We analyzed pattern blood pressure (BP) changes during thedevelopment patients with or without using data from MCDS FOSduring 7-year follow-up. Diabetes at baseline was significant predictor incident (in FOS,odds ratio, 3.14; 95% confidence interval,...
See also: Commentaire de travail P. Sharma et al., pp. 400Endoscopy 2011; 43(05): 464-464DOI: 10.1055/s-0031-1291801
Introduction: Penile injuries can comprise amputation, strangulation, fracture, and avulsion injury. The most frequent of these is a penile fracture. If addressed, it seeks immediate intervention that cause consequences such as erectile dysfunction. This case analysis highlights the need for quick detection prompt surgical to prevent long-term sexual we report Case Presentation: 51- year-old man presenting with sudden pain, swelling, an unusual shape his penis after traumatic intercourse. A...
Abstract Apoptotic loss of CD4+ T cells has been proposed as a mechanism cell depletion in human immunodeficiency virus (HIV) infections resulting immunodeficiency. The Env glycoprotein implicated apoptosis uninfected bystander via gp120 binding to CD4/CXC chemokine receptor 4 well the fusion/hemifusion process mediated by gp41. Using an vitro model coculture Env-expressing effectors and targets, we find that fact correlates with gp41-induced hemifusion. Further, apoptotic pathway initiated...
ABSTRACT Previously, we have characterized feline CD4 + CD25 T-regulatory (Treg) cells with regard to their immune regulatory properties and ability support immunodeficiency virus (FIV) replication in vitro vivo. Our studies showed that while were capable of replicating FIV the presence interleukin-2 (IL-2) alone, − harbored a latent infection required strong mitogenic stimulus activate replication. In present study, investigated mechanisms governing preferential highly purified Treg...
Depression affects a significant proportion of the population, with 1-year and lifetime prevalence 3–5% 10–30% respectively. Full remission is achieved in only third patients following treatment first-line antidepressant. There need for novel treatments treatment-resistant depression (TRD). Dysregulation hypothalamic–pituitary–adrenal (HPA) axis has been described depression. persistent rise levels cortisol (end product HPA axis) impairment negative feedback inhibition mechanism axis. found...
The loss of CD4(+) T cells in HIV-1 infections is hypothesized to be caused by apoptosis bystander mediated cell surface-expressed Env glycoprotein. However, the mechanism which mediates this process remains controversial. Specifically, role gp120 binding CD4 and CXCR4 versus fusion gp41 unresolved. Env-induced has been shown gp41-dependent correlates with redistribution membrane lipids between Env-expressing target (hemifusion). Using a rational mutagenesis approach aimed at targeting...
Abstract Biochemical studies have demonstrated that phosphorylation of lymphocyte cell kinase (p56 lck ) is crucial for activation signaling cascades following T receptor (TCR) stimulation. However, whether phosphorylation/dephosphorylation the activating or inhibitory tyrosine residues occurs upon controversial. Recent advances in intracellular staining phospho‐epitopes and cytometric analysis, requiring few cells, opened up novel avenues field immunological signaling. Here, we assessed p56...
Retrovirus assembly is a complex process that requires the orchestrated participation of viral components and host-cell factors. The concerted movement different proteins to specific sites in plasma membrane allows for virus particle ultimately budding maturation infectious virions. soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) constitute minimal machinery catalyzes fusion intracellular vesicles with membrane, thus regulating trafficking. Using siRNA dominant...
HIV-1 infections lead to a progressive depletion of CD4 cells culminating in AIDS. The coreceptor usage by HIV varies from CCR5 (R5) tropic early infection CXCR4 (X4) later infections. Although the switch R5 X4 is well associated with progression AIDS, role disease especially patients infected exclusively isolates throughout remains enigmatic. To better understand and envelope AIDS pathogenesis, we asked whether levels and/or Env-mediated fusion determine apoptosis bystander cells. We...