A5021471943- Lysosomal Storage Disorders Research
- Artificial Intelligence in Healthcare
- Calcium signaling and nucleotide metabolism
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Immune Cell Function and Interaction
- Genetics, Bioinformatics, and Biomedical Research
- Immunotherapy and Immune Responses
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- COVID-19 diagnosis using AI
- CAR-T cell therapy research
- Artificial Intelligence in Healthcare and Education
- Cystic Fibrosis Research Advances
- Nanoparticles: synthesis and applications
- Congenital Heart Disease Studies
- Autophagy in Disease and Therapy
- Carbohydrate Chemistry and Synthesis
- Protist diversity and phylogeny
- Genomics and Rare Diseases
- Platelet Disorders and Treatments
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- Immune cells in cancer
- RNA regulation and disease
Meharry Medical College
2015-2024
Tata Main Hospital
2024
Sarojini Naidu Medical College
2019-2022
Sir Ganga Ram Hospital
2013
University of North Texas
2013
University of North Texas Health Science Center
2013
Lady Hardinge Medical College
1995
Kalawati Saran Children's Hospital
1995
Bronchiectasis is a common but neglected chronic lung disease. Most epidemiological data are limited to cohorts from Europe and the USA, with few low-income middle-income countries. We therefore aimed describe characteristics, severity of disease, microbiology, treatment patients bronchiectasis in India.The Indian registry multicentre, prospective, observational cohort study. Adult (≥18 years) CT-confirmed were enrolled 31 centres across India. Patients due cystic fibrosis or traction...
Several neurodegenerative diseases and brain injury involve reactive oxygen species implicate oxidative stress in disease mechanisms. Hydrogen peroxide (H2O2) formation due to mitochondrial superoxide leakage perpetuates neuronal injury. Catalase, an H2O2-degrading enzyme, thus remains important antioxidant therapy target. However, catalase is restricted by its labile nature inadequate delivery. Here, a nanotechnology approach was evaluated using catalase-loaded, poly(lactic co-glycolic...
Cyclodextrins (CDs) are cyclic oligosaccharides; the most common CDs contain six, seven, or eight glucose units called α-CDs, β-CDs, and γ-CDs, respectively. The use of in biomedical research is increasing due to their ability interact with membrane lipids as well a wide variety poorly water-soluble molecules. We assessed impact CD cavity size, occupancy, substitutions on cytotoxicity cholesterol homeostasis. potency CD-mediated was order γ-CDs. Substitutions hydroxypropyl carboxymethyl...
Background Identifying risk factors for poor outcomes can help with stratification and targeting of treatment. Risk mortality exacerbations have been identified in bronchiectasis but almost exclusively studied European North American populations. This study investigated the outcome a large population patients enrolled India. Methods The Multicentre Bronchiectasis Audit Research Collaboration (EMBARC) Respiratory Network India (EMBARC-India) registry is prospective observational adults...
Wearable sensors are increasingly being explored in health care, including cancer for their potential continuously monitoring patients. Despite growing adoption, significant challenges remain the quality and consistency of data collected from wearable sensors. Moreover, preprocessing pipelines to clean, transform, normalize, standardize raw have not yet been fully optimized.
Abstract Missense variants can have pleiotropic effects on protein function and predicting these be difficult. We performed near-saturation deep mutational scanning of P2RY8, a G-protein-coupled receptor that promotes germinal center B cell confinement. assayed the effect each variant surface expression, migration, proliferation. delineated affected both expression function, independently discrepantly migration also used cryo-electron microscopy to determine structure activated, ligand-bound...
Abstract Niemann–Pick type C (NPC) disease is a fatal hereditary neurodegenerative disorder characterized by massive accumulation of cholesterol in lysosomes and late endosomes due to defect intracellular trafficking. Dysfunction trafficking responsible for about 50 rare inherited lysosomal storage disorders including NPC. The proteins NPC1 NPC2 play crucial role from other cellular compartments. However, the detailed mechanisms at endosomes/lysosomes (LE/LY) are poorly understood. Studies...
Background: Sequencing Mendelian arrhythmia genes in individuals without an indication for genetic testing can identify carriers of pathogenic or likely (P/LP) variants. However, the extent to which these variants are associated with clinically meaningful phenotypes before after return variant results is unclear. In addition, majority discovered currently classified as uncertain significance, limiting clinical actionability. Methods: The eMERGE-III study (Electronic Medical Records and...
Abstract Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused by mutations in NPC1 and NPC2 genes that result an accumulation of cholesterol lysosomes. The majority children with NPC die adolescence. Currently, no FDA-approved therapies exist for the mechanisms are not fully understood. Our recent study reports from other laboratories showed 2-hydroxypropyl-γ-cyclodextrin (HPγCD) alleviates NPC1-deficient cells spite its low binding affinity cholesterol. In this...
// Samuel T. Pellom Jr. 1, 2, 3 , Duafalia F. Dudimah 1 Menaka C. Thounaojam Roman V. Uzhachenko Ashutosh Singhal Ann Richmond 4, 5, 6, 7, 8, 9 Anil Shanker 3, Department of Biochemistry and Cancer Biology, School Medicine, Meharry Medical College, Nashville, Tennessee, USA 2 Microbiology Immunology, Graduate Studies Research, 4 Tennessee Valley Healthcare System, 5 Veterans Affairs, 6 Vanderbilt University Center, 7 Host-Tumor Interactions Research Program, Vanderbilt-Ingram Comprehensive...
A total of 110 consecutive hospitalized children with severe lower respirator tract infection were studied the aim determining main bacterial pathogens responsible. Of these, 57 classified as pneumonia and 53 very pneumonia. Streptococcus pneumoniae was most common organism identified in 24.6% 32.1% cases pneumonia, respectively, followed by Haemophilus influenzae type b, which seen 17.5% 20.8%, respectively. The highest diagnostic yield latex particle agglutination test on serum urine....
As data grows exponentially across diverse fields, the ability to effectively leverage big has become increasingly crucial. In field of science, however, minority groups, including African Americans, are significantly underrepresented. With strategic role minority-serving institutions enhance diversity in science workforce and apply health disparities, National Institute for Minority Health Disparities (NIMHD) provided funding September 2021 six Research Centers Institutions (RCMI) improve...
Pulmonary sequestration is a condition in which segment of dysplastic lung tissue or lobe present without any communication with the rest tracheobronchial tree, and receives an anomalous systemic blood supply separate from lung. It piece nonfunctional foregut embryonic remnant. may as haemoptysis, this mimic other respiratory diseases like Tuberculosis, Bronchiectasis Malignancy. We case 16-year-old female, who came complaints massive haemoptysis. A CT Thorax done showed right lower lung,...
<sec> <title>BACKGROUND</title> Wearable sensors are increasingly being explored in health care, including cancer for their potential continuously monitoring patients. Despite growing adoption, significant challenges remain the quality and consistency of data collected from wearable sensors. Moreover, preprocessing pipelines to clean, transform, normalize, standardize raw have not yet been fully optimized. </sec> <title>OBJECTIVE</title> This study aims conduct a scoping review techniques...
The working hypothesis driving this research is that a molecular defect in the retrograde receptor recycling pathway involving dynactin complex cancer cells elevates level of growth factor receptors on their outer surface resulting aggressive these cells. We have identified suppression p25 subunit (DCTN5) as defect. Aggressive breast lacking DCTN5 significantly higher levels such EGFR and PAR1 surface. Forced expression wild‐type complemented restored tested. Bioinformatics analysis revealed...
Abstract In 21,846 eMERGE-III participants, sequencing 10 arrhythmia syndrome disease genes identified 123 individuals with pathogenic or likely (P/LP) variants. Compared to non-carriers, P/LP carriers had a significantly higher burden of phenotypes in their electronic health records (EHRs). Fifty one participants variant results returned. Eighteen these 51 inherited diagnoses (primarily long QT syndrome), and 11/18 were made only after After vitro functional evaluation 50 variants uncertain...
Macrophages are among the immune cells that recruited at site of solid tumor to phagocytose tissue debris and destroy through phagocytosis‐induced inflammatory response. Thus, unless manipulated by cancer cells, response induced in macrophages should kill bringing collateral damage cells. One emerging mechanisms induction is increase level cytotoxic scAlu RNA these Through enhancement reactive oxygen species levels, activates NLRP3 inflammasome cause cell death via caspase pathway. We found...
Abstract Breast tumor cells are often subject to various forms of proteotoxic stress in their microenvironment mainly presented by the stromal cells. We found that highly aggressive breast cancer triple negative subtype (TNBC) significantly more tolerant environmental than non-aggressive Major objective research here is understand mechanism induction cytotoxic Alu RNA stressed and how TNBC pacify this non-coding RNA-mediated cytotoxicity. present evidence stress-induced activation HSF1...
Abstract The interaction between the innate and adaptive immune components is fundamental for an effective antitumor immunity. Our studies in murine solid tumor models showed that productive effector response relies on functional crosstalk effectors—natural killers (NK), effectors—cytolytic CD8+T lymphocytes. We found this lymphocyte cooperativity NK cells can prevent development of antigen-escape variants. In study, we first investigated role physical contacts during cells. Since, studying...
Niemann‐Pick type C (NPC) disease is a neurodegenerative disorder caused by mutations in NPC1 or NPC2 gene, encoding lysosomal membrane and luminal protein, respectively. NPC linked to the disruption of intracellular cholesterol trafficking characterized excessive accumulation free lysosomes. The functions proteins are involved exit poorly understood mechanisms. Understanding molecular mechanisms export critical for therapy. We hypothesized that lysosome‐associated protein 1 (LAMP‐1) can...
Background: Return of incidental genetic findings is recommended for pathogenic/likely pathogenic (P/LP) variants in Mendelian arrhythmia genes. The extent to which these are associated with phenotypes unselected populations unknown. Objective: Assess the impact return results (RoR) P/LP 4 genes research participants not selected cardiovascular disease. Methods: cohort included 24,410 from Electronic Medical Records and Genomics Network. Rare (minor allele frequency <1%) KCNE1 , KCNH2...
This paper describes our efforts to enhance the research capacity of Research Centers in Minority Institutions (RCMI) program at Meharry Medical College and foster collaborations between RCMI a newly established School Applied Computational Sciences (SACS). These include offering subawards collaborative groups, financial support graduate students for their participation research, performing need assessment understand needs community so as guide project implementation, providing data science...