A5060095489- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Viral-associated cancers and disorders
- Malaria Research and Control
- Mosquito-borne diseases and control
- Complement system in diseases
- Parasitic infections in humans and animals
- Cardiomyopathy and Myosin Studies
- Synthesis and Biological Evaluation
- Diversity and Career in Medicine
- Lymphoma Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Coenzyme Q10 studies and effects
- SARS-CoV-2 and COVID-19 Research
- Healthcare Systems and Technology
- Global Health Workforce Issues
- Vaccine Coverage and Hesitancy
- Biochemical and Molecular Research
- Syphilis Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Innovations in Medical Education
- Viral Infections and Immunology Research
- Bone and Joint Diseases
- Global Health and Surgery
Baylor College of Medicine
2014-2025
Center for Innovation
2019-2024
Michael E. DeBakey VA Medical Center
2019-2022
University of California, San Francisco
2022
MedStar Union Memorial Hospital
2022
University of California, Irvine
2022
Health Services Research & Development
2020
Office of Infectious Diseases
2020
University of Michigan–Ann Arbor
2014
Johns Hopkins University
2014
In early 2020, a novel coronavirus (SARS-CoV-2) began to trickle through global communities, resulting in pandemic of proportions not seen since 1918.In the US, while disease caused by SARS-CoV-2, COVID-19, initially affected international travelers and their close contacts, it is now ravaging many disadvantaged communities.As past pandemics, social economic determinants will strongly influence susceptibility health outcomes COVID-19; thus, predictable that low-income vulnerable US...
Background Chagas disease control campaigns relying upon residual insecticide spraying have been successful in many Southern American countries. However, some areas, rapid reinfestation and recrudescence of transmission occurred. Methodology/Principal Findings We conducted a cross-sectional survey the Bolivian Chaco to evaluate prevalence risk factors for T. cruzi infection 11 years after two rounds blanket application. used cubic B-spline model estimate change force over time based on...
Background Antibodies that protect against Plasmodium falciparum (Pf) malaria are only acquired after years of repeated infections. The B cell biology underlies this observation is poorly understood. We previously reported "atypical" memory cells increased in children and adults exposed to intense Pf transmission Mali, similar what has been observed individuals infected with HIV. In study we examined subsets -infected Peru Mali determine if intensity correlates atypical expansion....
Abstract By late April 2020, public discourse in the United States had shifted toward idea of using more targeted case-based mitigation tactics (eg, contact tracing) to combat coronavirus disease 2019 (COVID-19) transmission while allowing for safe “reopening” society, an effort reduce social, economic, and political ramifications associated with stricter approaches. Expanded tracing-testing efforts were touted as a key solution that would allow precision approach, thus preventing economies...
This JAMA Insights provides recommendations for Chagas disease screening, diagnosis, and management in the US.
Infection by Trypanosoma cruzi , the agent of Chagas disease, can irreparably damage cardiac and gastrointestinal systems during decades parasite persistence related inflammation in these tissues. Diagnosis chronic disease requires confirmation multiple serological assays due to imperfect performance existing clinical tests. Current serology tests utilize antigens discovered over three ago with small specimen sets predominantly from South America, lower test has been observed patients who...
Abstract Background Neurocysticercosis (NCC) is a neglected tropical disease caused by infection with the pork tapeworm Taenia solium that affects 2-8 million people globally and responsible for ∼30% of epilepsy cases in endemic countries. Based on case series data, > 4,000 new NCC are estimated to occur annually US. The gold standard diagnosis as outlined Infectious Disease Society America (IDSA) guidelines neuroimaging computed tomography (CT: detect calcifications) magnetic...
Abstract Background Chagas disease (CD), caused by Trypanosoma cruzi, is a neglected of poverty affecting >6 million people in the Americas, including >200,000 US. While many are asymptomatic, 20-30% develop end-organ damage like cardiomyopathy. Early diagnosis and treatment essential to reduce this risk; however, US clinicians generally unaware for whom CD screening recommended (Table 1) how order it. >1.5 born continental Latin America live Harris County, TX, making an...
The development of clinical immunity to Plasmodium falciparum malaria is thought require years parasite exposure, a delay often attributed difficulties in developing protective antibody levels. In this study, we evaluated several P. vaccine candidate antigens, including apical membrane antigen 1 (AMA-1), circumsporozoite protein (CSP), erythrocyte binding 175 (EBA-175), and the 19-kDa region merozoite surface (MSP1(19)). After observing more robust response MSP1(19), magnitude longevity IgG...
ABSTRACT Trypanosoma cruzi causes Chagas disease, which affects an estimated 7 million to 8 people. disease is endemic throughout Latin America, with the highest prevalence in Bolivia. Conventional diagnosis requires a well-equipped laboratory experienced personnel. We evaluated Detect Plus (CDP) (InBios, Seattle, WA), rapid immunochromatographic assay for IgG antibodies T. . CDP performance was compared infection status based on results obtained by indirect hemagglutination assay,...
Background Twenty to thirty percent of persons with Trypanosoma cruzi infection eventually develop cardiomyopathy. If an early indicator were be identified and validated in longitudinal studies, this could enable treatment prioritized for those at highest risk. We evaluated cardiac extracellular matrix remodeling markers across stages T. infected (Tc+) uninfected (Tc−) individuals. Methods Participants recruited a public hospital Santa Cruz, Bolivia assigned severity by electrocardiogram...
For American professional and graduate health sciences trainees, a mentored fellowship in low- or middle-income country (LMIC) can be transformative experience of personal growth scientific discovery. We invited 86 trainees the Fogarty International Clinical Research Scholars Fellows Program Fulbright–Fogarty Fellowship 2011–2012 cohorts to contribute essays about formative experiences from their fellowships. Nine contributed that were analyzed using an inductive approach. The most...
This perspective highlights the inconsistent integration of travel health education across medical, nursing, and pharmacy educational programs globally calls for standardized competencies based on International Society Travel Medicine’s (ISTM) Body Knowledge to help improve patient care outcomes as global returns pre-pandemic levels.
Abstract Background In high-transmission areas, developing immunity to symptomatic Plasmodium falciparum infections requires 2–10 years of uninterrupted exposure. Delayed malaria-immunity has been attributed difficult-to-develop and then short-lived antibody responses. Methods a study area with <0.5 P. infections/person/year, responses the MSP1-19kD antigen were evaluated associations in children adults. months surrounding during malaria seasons 2003–2004, 1,772 participants received ≥6...
Abstract Background Plasmodium falciparum re-emerged in Iquitos, Peru 1994 and is now hypoendemic (< 0.5 infections/person/year). Purportedly non-immune individuals with discrete (non-overlapping) P. infections can be followed using this population dynamic. Previous work demonstrated a strong association between population's antibody response to Pf MSP1-19KD protection against febrile illness parasitaemia. Therefore, some selection for allelic diversity would expected if the...
Morbidity and mortality from Chagas cardiomyopathy have declined over the last three decades because of disruption domestic vector-borne transmission, improved Trypanosoma cruzi infection treatment programs, increasing availability advanced cardiac care.However, Gran Chaco, an ecological zone that includes parts Argentina, Bolivia, Paraguay, continues to struggle with extremely high rates vector infestation T. infection.In addition, this region is one poorest in world, most individuals...