A5055291213- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Advanced X-ray and CT Imaging
- Congenital Heart Disease Studies
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Tracheal and airway disorders
- Viral Infections and Immunology Research
- Esophageal and GI Pathology
- Renal and Vascular Pathologies
- Cardiovascular Disease and Adiposity
- Industrial Vision Systems and Defect Detection
- Cardiovascular Issues in Pregnancy
- Advanced X-ray Imaging Techniques
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Maternal and fetal healthcare
- Amoebic Infections and Treatments
- Advanced Neural Network Applications
- Pregnancy and preeclampsia studies
- Electron Spin Resonance Studies
King's College London
2021-2025
St Thomas' Hospital
2022-2024
Royal Brompton Hospital
2016-2024
Guy's and St Thomas' NHS Foundation Trust
2022-2024
Evelina London Children's Healthcare
2022
Royal Brompton & Harefield NHS Foundation Trust
2020-2021
St George's Hospital
2021
St George’s University Hospitals NHS Foundation Trust
2016-2021
The General Hospital of Heraklion "Venizeleio-Pananio"
2018
St George's, University of London
2016
To develop a simultaneous T1 , T2 and T1ρ cardiac magnetic resonance fingerprinting (MRF) approach to enable comprehensive contrast agent-free myocardial tissue characterization in single breath-hold scan.A 2D gradient-echo electrocardiogram-triggered MRF sequence with low flip angles, varying magnetization preparation, spiral trajectory was acquired at 1.5 T encode T1⍴ simultaneously. The images were reconstructed using low-rank inversion, regularized multicontrast patch-based higher-order...
Abstract Purpose To develop a novel, free‐breathing, 3D joint // mapping sequence with Dixon encoding to provide co‐registered , and maps water‐fat volumes isotropic spatial resolution in single min scan for comprehensive contrast‐agent‐free myocardial tissue characterization simultaneous evaluation of the whole‐heart anatomy. Methods An interleaving over 5 heartbeats is proposed encoding, data acquired gradient‐echo readout 2D image navigators enable respiratory efficiency. Images were...
Three dimensional, whole-heart (3DWH) MRI is an established non-invasive imaging modality in patients with congenital heart disease (CHD) for the diagnosis of cardiovascular morphology and clinical decision making. Current techniques utilise diaphragmatic navigation (dNAV) respiratory motion correction gating are frequently limited by long acquisition times. This study proposes evaluates diagnostic performance a gating-free framework, which considers image-based (iNAV), highly accelerated...
Cardiovascular magnetic resonance (CMR) is an important imaging modality for the assessment and management of adult patients with congenital heart disease (CHD). However, conventional techniques three-dimensional (3D) whole-heart acquisition involve long unpredictable scan times methods that accelerate scans via k-space undersampling often rely on iterative reconstructions. Deep-learning-based reconstruction have recently attracted much interest due to their capacity provide fast...
To assess the clinical performance of three-dimensional, free-breathing, Magnetization Transfer Contrast Bright-and-black blOOd phase-SensiTive (MTC-BOOST) sequence in adult congenital heart disease (ACHD).In this prospective study, participants with ACHD undergoing cardiac MRI between July 2020 and March 2021 were scanned T2-prepared balanced steady-state free precession proposed MTC-BOOST sequence. Four cardiologists scored their diagnostic confidence on a four-point Likert scale for...
The application of cardiovascular magnetic resonance angiography (CMRA) for the assessment thoracic aortic disease is often associated with prolonged and unpredictable acquisition times residual motion artefacts. To overcome these limitations, we have integrated undersampled image-based navigators inline non-rigid correction to enable a free-breathing, contrast-free Cartesian CMRA framework visualization aorta in short predictable scan 3 min.
Purpose The aim of this study is to develop and optimize an adiabatic () mapping method for robust quantification spin‐lock (SL) relaxation in the myocardium at 3T. Methods Adiabatic SL (aSL) preparations were optimized resilience against inhomogeneities using Bloch simulations. Optimized ‐aSL, Bal‐aSL ‐aSL modules, each compensating different inhomogeneities, first validated phantom human calf. Myocardial was performed a single breath‐hold cardiac‐triggered bSSFP‐based sequence. Then,...
Free-breathing Magnetization Transfer Contrast Bright blOOd phase SensiTive (MTC-BOOST) is a prototype balanced-Steady-State Free Precession sequence for 3D whole-heart imaging, that employs the endogenous magnetisation transfer contrast mechanism. This achieves reduction of flow and off-resonance artefacts, often arise with clinical T2prepared sequence, enabling high quality, contrast-agent free imaging thoracic cardiovascular anatomy. Fully-sampled MTC-BOOST acquisition requires long scan...
Background Bright‐blood lumen and black‐blood vessel wall imaging are required for the comprehensive assessment of aortic disease. These images usually acquired separately, resulting in long examinations potential misregistration between images. Purpose To characterize performance an accelerated respiratory motion‐compensated three‐dimensional (3D) cardiac MRI technique simultaneous contrast‐free with interleaved T2 inversion recovery prepared sequence (iT2Prep‐BOOST). Study Type...
Purpose To develop a motion‐robust reconstruction technique for free‐breathing cine imaging with multiple averages. Method Retrospective motion correction through average k‐space data elimination (REMAKE) was developed using iterative removal of segments (from individual samples) that contribute most to corruption while combining any remaining across signal A variant REMAKE, termed REMAKE+, address losses in SNR due information removal. With reconstructions different initial conditions were...
Native T1 and T1ρ mapping has shown promising results for the detection of focal diffuse myocardial fibrosis without need contrast agents, whereas T2 enables characterisation inflammation edema. However, conventional maps are acquired in sequential 2D breath-hold scans with limited heart coverage. Here, we propose a novel free-breathing, 3D joint T1/T1ρ/T2 sequence Dixon encoding to provide whole-heart T1, co-registered water/fat volumes isotropic spatial resolution comprehensive...