A5066434544- Monoclonal and Polyclonal Antibodies Research
- Nanofabrication and Lithography Techniques
- Biotin and Related Studies
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Asthma and respiratory diseases
- Regulation of Appetite and Obesity
- Allergic Rhinitis and Sensitization
- Advanced Fluorescence Microscopy Techniques
- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Galectins and Cancer Biology
- Protein Structure and Dynamics
- COVID-19 Impact on Reproduction
- Advanced Proteomics Techniques and Applications
- Urticaria and Related Conditions
- thermodynamics and calorimetric analyses
- Genetic Neurodegenerative Diseases
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Food Allergy and Anaphylaxis Research
- Neurogenetic and Muscular Disorders Research
- Lipid Membrane Structure and Behavior
- Receptor Mechanisms and Signaling
- Educational Leadership and Innovation
Komfo Anokye Teaching Hospital
2021-2023
Centre National de la Recherche Scientifique
2017
Université de Strasbourg
2017
Inserm
2017
Karlsruhe Institute of Technology
2011-2015
University at Buffalo, State University of New York
2013-2014
Lymphoid-specific tyrosine phosphatase (LYP), a member of the protein (PTP) family signaling enzymes, is associated with broad spectrum autoimmune diseases. Herein we describe our structure-based lead optimization efforts within 6-hydroxy-benzofuran-5-carboxylic acid series culminating in identification compound 8b, potent and selective inhibitor LYP K(i) value 110 nM more than 9-fold selectivity over large panel PTPs. The structure complex 8b was obtained by X-ray crystallography, providing...
Multiple-allergen testing for high throughput and sensitivity requires the development of miniaturized immunoassays that allow a large test area require only small volume analyte, which is often available in limited amounts. Developing such biochips containing arrays allergens needs application technique able to deposit molecules at resolution speed while preserving its functionality. Lipid dip-pen nanolithography (L-DPN) an ideal create biologically active surfaces, it has already been...
In addition to their actions in the cell nucleus, glucocorticoids exhibit rapid non‐nuclear responses that are mechanistically not well understood. To explain these effects, localization of a glucocorticoid receptor (GR) expressed mast cells as GFP fusion was analyzed after activation on allergenic lipid arrays. These arrays were produced glass slides by dip‐pen nanolithography (DPN) and total internal reflection (TIRF) microscopy used visualize GR. A glucocorticoid‐independent ‐dependent...
The human androgen receptor (AR) is a ligand inducible transcription factor that harbors an amino terminal domain (AR-NTD) with ligand-independent activation function. AR-NTD intrinsically disordered and displays aggregation properties conferred by the presence of poly-glutamine (polyQ) sequence. length polyQ sequence as well its adjacent motifs modulate this property. also contains conserved KELCKAVSVSM motif intrinsic property to form amyloid fibrils under mild oxidative conditions. As...
Spinal muscular atrophy (SMA) is an autosomal recessive inherited motor neuron disease characterized by progressive muscle weakness due to degeneration and loss of the anterior horn cells in spinal cord brain stem nuclei from foetal life through infancy childhood. SMA prevalent Ghanaian children, though not widely reported. Cases are likely missed or misdiagnosed lack expertise investigations. Newborn screening currently available Ghana. The management remains supportive as newly approved...
Digital Transformation Education has received greater attention in teaching and learning, however, there is a scarcity of studies on the challenges, effectiveness, perceptions Computer-Assisted Instruction (CAI), especially Colleges (CoE). In addressing these, study used mixed method research design using 12 Physics tutors 254 students from 3 CoE purposively selected Sekyere South District Mampong Municipality. Interviews questionnaires were for data collection analysis was done Statistical...
The human androgen receptor (AR) is a ligand inducible transcription factor harboring an amino terminal domain (AR-NTD) hosting the independent activation function. AR-NTD intrinsically disordered and display aggregation properties conferred by presence of poly-glutamine (polyQ) sequence 22 residues. length polyQ sequence, as well adjacent motifs modulate this property. contains also conserved motif KELCKAVSVSM that displays intrinsic property to form amyloid fibrils under mild oxidative...
The emergence of COVID-19 by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) in 2019 has seen evolving data reporting infrequent infection children and mostly mild disease for who contract the infection. A form recently reported Europe North America describes multisystem inflammation (MIS-C), presenting as toxic-shock-like Kawasaki-like syndromes. Data on MIS-C Africa is being documented with recent reports from South Nigeria black children, but information Ghana yet to be...
Severe combined immunodeficiency (SCID) and immunocompetent BALBc mice strains may constitute resourceful model‐candidates for revealing inflammation‐mediated mechanisms involved in high fat diet (HFD) induced insulin resistance (IR). This study included 32 animals groups of 4 all combinations male (M), female (F), BALBc, SCID, low (LFD, 4.1% fat), HFD (35% fat) a total 21 weeks. All switched to 10% fat, between week 12 15. Biweekly fasting levels adipokines, inflammatory cytokines growth...
A 3-month-old female infant was referred to a teaching hospital with 3-day history of fever, fast breathing, cough and 19 hours yellowish discoloration sclera. She deeply jaundiced febrile, had hepatosplenomegaly, microcephalic thrombocytopenic. Child worked out treated for bacterial pneumonia, atypical pulmonary tuberculosis, fungal opportunist infection, heart failure. oxygen dependent throughout the 2 months admission deteriorateddespite all interventions. Considerations viral infection...