About
Contact & Profiles
A5021804697
Research Areas
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
Albany Medical Center Hospital
2018-2019
Abstract Group 2 innate lymphoid cells (ILC2) are tissue-resident, long-lived effector implicated in allergy and asthma. Upon activation, mature ILC2 rapidly secrete large amounts of type-2 cytokines other molecules. The molecular pathways that drive activation not well understood. In this study, we report the transcriptional controller core binding factor β (CBFβ) is required for activation. Deletion or inhibition CBFβ did impair maintenance at homeostasis but abolished during allergic...
10.4049/jimmunol.1800852
article
EN
The Journal of Immunology
2019-02-06
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