A5007638271- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Erythrocyte Function and Pathophysiology
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Alzheimer's disease research and treatments
- Immunodeficiency and Autoimmune Disorders
- Tryptophan and brain disorders
- Protein Degradation and Inhibitors
- Air Quality and Health Impacts
- HIV Research and Treatment
- Extracellular vesicles in disease
- GDF15 and Related Biomarkers
- Hematopoietic Stem Cell Transplantation
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Inflammatory Bowel Disease
- Veterinary medicine and infectious diseases
- Cellular transport and secretion
- Microscopic Colitis
ImmunityBio (United States)
2025
Amsterdam University Medical Centers
2022
University of Amsterdam
2022
Albany Medical Center Hospital
2019-2021
The University of Melbourne
2011-2012
Peter MacCallum Cancer Centre
2011-2012
In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. this study, analyzing mutant mice and we demonstrate a critical, intrinsic role for peripheral survival function. mutation selectively diminished abundance circulating naive cells both species, DOCK8-deficient most displayed an exhausted CD45RA+CCR7− phenotype. Analyses revealed abnormalities to autonomous primarily...
Despite mounting evidence suggesting the involvement of immune system in regulating brain function, specific role and inflammatory cells neurodegenerative diseases remain poorly understood. In this study, we report that depletion NK cells, a type innate lymphocytes, alleviates neuroinflammation, stimulates neurogenesis, improves cognitive function triple-transgenic Alzheimer disease (AD) mouse model. brains AD model (3xTg-AD) mice exhibited an enhanced proinflammatory profile. Depletion by...
Increasing evidence has challenged the traditional view about immune privilege of brain, but precise roles cells in regulating brain physiology and function remain poorly understood. Here, we report that tissue-resident group 2 innate lymphoid (ILC2) accumulate choroid plexus aged brains. ILC2 are long-lived, relatively resistant to cellular senescence exhaustion, capable switching between cell cycle dormancy proliferation. They functionally quiescent at homeostasis can be activated by IL-33...
Abstract The next generation of NK-92® (also known as aNKTM) cells will include inducible kill switches and enhanced cytotoxicity to make them safer more effective, without the need irradiate before infusion into patients. Because their longevity in vivo allogeneic nature, NK-92 are susceptible rejection by patient’s own immune system be equipped with mechanisms prevent such rejection. We have genetically engineered targeting a combination molecules that allow undetected T-cells well...
Abstract The effects of aging on innate immunity and the resulting impacts immunosenescence remain poorly understood. Here, we report that induces compartmentalized changes to development function group 2 lymphoid cells (ILC2), an ILC subset implicated in pulmonary homeostasis tissue repair. Aging enhances bone marrow early ILC2 through Notch signaling, but newly generated circulating are unable settle lungs replenish concomitantly declining mature lung pool aged mice. Aged...
Asthma is a complicated chronic inflammatory disorder characterized by airway inflammation and bronchial hyperresponsiveness. Group 2 innate lymphoid cells (ILC2) are tissue-resident effector that can mediate hyperresponsiveness through production of IL-5, IL-13 VEGFA. ILC2 in asthma patients exhibit an activated phenotype. However, molecular pathways control activation not well understood.MYC expression was examined sorted from peripheral blood healthy controls or cultured with without...
Aging is paradoxically associated with a deteriorated immune defense (immunosenescence) and increased basal levels of tissue inflammation (inflammaging). The lung particularly sensitive to the effects aging. cell mechanisms underlying physiological aging remain poorly understood. Here we reveal that leads interferon signaling elevated concentrations chemokines in lung, which infiltration monocytes into parenchyma. scRNA-seq identified novel Type-1 dependent monocyte subset (MO-ifn)...
The immune pathways in Alzheimer's disease (AD) remain incompletely understood. Our recent study indicates that tissue-resident group 2 innate lymphoid cells (ILC2) accumulate the brain barriers of aged mice and their activation alleviates aging-associated cognitive decline. regulation function ILC2 AD, however, unknown.In this study, we examined numbers functional capability from triple transgenic AD (3xTg-AD) control wild-type mice. We investigated effects treatment with IL-5, a cytokine...
Myeloid cells are critical determinants of the sustained inflammation in Crohn's Disease (CD). Targeting such may be an effective therapeutic approach for refractory CD patients. Bromodomain and extra-terminal domain protein inhibitors (iBET) potent anti-inflammatory agents; however, they also possess wide-ranging toxicities. In current study, we make use a BET inhibitor containing esterase sensitive motif (ESM-iBET), which is cleaved by carboxylesterase-1 (CES1), highly expressed...
Abstract Group 2 innate lymphoid cells (ILC2) are tissue-resident, long-lived effector implicated in allergy and asthma. Upon activation, mature ILC2 rapidly secrete large amounts of type-2 cytokines other molecules. The molecular pathways that drive activation not well understood. In this study, we report the transcriptional controller core binding factor β (CBFβ) is required for activation. Deletion or inhibition CBFβ did impair maintenance at homeostasis but abolished during allergic...
Abstract Graft-versus-host disease (GVHD) is a leading cause of mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Mature donor T cells in the graft mediate graft-versus-leukemia (GVL) responses against residual tumor cells, which may persist after pre-transplant conditioning regimens. Importantly, same mature also GVHD. The transcription factor Cell Factor-1 (TCF-1) critical for development thymus. Using unique mouse model allo-HSCT to GVHD, we investigated...
Abstract Increasing evidence has challenged the traditional view about immune privilege of brain, but precise roles cells in regulating brain physiology and function remain poorly understood. Here we report that tissue-resident group 2 innate lymphoid (ILC2) accumulate choroid plexus aged brains. ILC2 are long-lived, relatively resistant to cellular senescence exhaustion, capable switching between cell cycle dormancy proliferation. They functionally quiescent at homeostasis can be activated...