A5014102761- Cutaneous Melanoma Detection and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Genomics and Diagnostics
- Medical Imaging and Pathology Studies
- Surgical site infection prevention
- Dermatological and COVID-19 studies
- Autoimmune and Inflammatory Disorders
- Wound Healing and Treatments
- Eosinophilic Disorders and Syndromes
- Cell Image Analysis Techniques
- Pulmonary Hypertension Research and Treatments
- Antenna Design and Analysis
- Immunotherapy and Immune Responses
- Cutaneous lymphoproliferative disorders research
- Single-cell and spatial transcriptomics
- Polyomavirus and related diseases
- Melanoma and MAPK Pathways
- Immunodeficiency and Autoimmune Disorders
- Plant Virus Research Studies
- Pressure Ulcer Prevention and Management
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Parvovirus B19 Infection Studies
- Chronic Lymphocytic Leukemia Research
- Sarcoidosis and Beryllium Toxicity Research
Loyola University Medical Center
2016-2024
Rochester General Hospital
2013
Overcoming bacterial antibiotic resistance requires alternative strategies. The ability of photoactivated collagen-embedded flavins (PCF) to reduce bioburden in infected pressure ulcers was investigated.Two were created on the dorsum female BALB/C mice (n=40, 35 g) maintaining a 5 mm skin bridge between lesions. Ulcers and surrounding covered with Tegaderm™ inoculated 0.1 mL 1 × 10(5) colony-forming units (CFU)/mL methicillin-resistant Staphylococcus aureus (MRSA). Fluid permitted reabsorb...
Abstract: Blau syndrome is a rare familial autoinflammatory disorder characterized by the triad of granulomatous dermatitis, polyarthritis, and uveitis. exhibits an autosomal dominant inheritance pattern can be caused gain-of-function mutation in nucleotide-binding oligomerization domain 2 (NOD2), member NOD-like receptor family recognition receptors. Mutations NOD2 cause upregulation inflammatory cytokines resultant autoinflammation. Because rarity this condition early onset symptoms, may...
Immune checkpoint inhibitor (ICI)-based cancer therapies cause a variety of cutaneous immune-related adverse events (irAEs) including immunobullous skin eruptions like bullous pemphigoid (BP). However, little is known about the underlying immunopathogenic drivers these reactions, and understanding unique gene expression profile immune composition BP-irAE remains critical knowledge gap in field oncodermatology/oncodermatopathology.BP-irAE (n = 8) de novo BP control biopsy samples were...
Abstract: Most melanocytic tumors are classified as benign or malignant based on clinical morphology, histology, and immunohistochemical (IHC) analysis. A subset of more challenging cases with ambiguous features may require further evaluation established ancillary diagnostic molecular studies, including fluorescence in situ hybridization and/or single nucleotide polymorphism array, to increase certainty. More recently, a gene expression-profiling (GEP) assay an IHC stain for the detection...
Abstract Papular‐purpuric “gloves and socks” syndrome (PPGSS) is a unique, self‐limited dermatosis characterized by edema, erythema, pruritic petechiae papules in distinct distribution. This often accompanied systemic symptoms, including fever, lymphadenopathy, asthenia, myalgia, arthralgias. PPGSS has also been described as manifestation of an underlying immunological mechanism that can be triggered viral or drug‐related antigens. A 32‐year‐old male developed painful eruption on the...
Objective methods for distinguishing melanoma in situ (MIS) from photodamaged skin (PS) are needed to guide treatment patients with melanocytic proliferations. Melanocyte density (MD) could serve as an objective histopathological criterion difficult cases. Calculating MD via manual cell counts (MCC) immunohistochemical (IHC)-stained slides has been previously published. However, the clinical application of this method is questionable, quantification MCC on cases time consuming, especially...
While drug-induced panniculitis is not uncommon in chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitor therapy, it rare for CML to initially present as a leukemic panniculitis. We the case of 45-year-old male with no relevant prior medical history presenting 6 months migratory nodules, 2 drenching night sweats, and 20 pound weight loss. Physical examination showed firm subcutaneous nodules overlying ecchymoses right lateral thigh left lower back. Biopsy nodule from lobular...