A5012598023- Environmental Toxicology and Ecotoxicology
- Effects and risks of endocrine disrupting chemicals
- Animal testing and alternatives
- Pharmaceutical and Antibiotic Environmental Impacts
- Pesticide and Herbicide Environmental Studies
- Toxic Organic Pollutants Impact
- Pesticide Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Pharmacogenetics and Drug Metabolism
- Risk and Safety Analysis
- Complementary and Alternative Medicine Studies
- Chemical Safety and Risk Management
- Agricultural safety and regulations
- Drug-Induced Hepatotoxicity and Protection
- Plant-based Medicinal Research
- Computational Drug Discovery Methods
- Immunotoxicology and immune responses
- Nephrotoxicity and Medicinal Plants
- Animal Genetics and Reproduction
- Water Quality Monitoring and Analysis
- Environmental Chemistry and Analysis
- Health, Environment, Cognitive Aging
- DNA Repair Mechanisms
- Advanced Chemical Sensor Technologies
- Reproductive biology and impacts on aquatic species
Health and Environmental Sciences Institute
2016-2025
Vrije Universiteit Amsterdam
2021
International Life Sciences Institute
2011-2017
Duke University
2006
The need to develop new tools and increase capacity test pharmaceuticals other chemicals for potential adverse impacts on human health the environment is an active area of development. Much this activity was sparked by two reports from US National Research Council (NRC) Academies Sciences, Toxicity Testing in Twenty-first Century: A Vision a Strategy (2007) Science Decisions: Advancing Risk Assessment (2009), both which advocated "science-informed decision-making" field risk assessment....
Abstract Flexible, rapid, and predictive approaches that do not require the use of large numbers vertebrate test animals are needed because chemical universe remains largely untested for potential hazards. Development robust new approach methodologies nontesting requires existing information via curated, integrated data sets. The ecological threshold toxicological concern (ecoTTC) represents one such methodology can predict a conservative de minimis toxicity value chemicals with little or no...
The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] guideline 210) is the primary used internationally to estimate chronic toxicity in support of ecological risk assessments chemical management programs. As part an ongoing effort develop efficient cost-effective alternatives FELS test, there a need identify describe potential adverse outcome pathways (AOPs) relevant toxicity. To this endeavor, authors outline illustrate overall strategy...
The fish early life-stage (FELS) test guideline (OECD 210 or OCSPP 850.1400) is the most frequently used bioassay for predicting chronic toxicity and supporting aquatic ecological risk assessments around world. For each chemical, FELS requires a minimum of 360 1 to 3 months from initiation termination. Although valuable full life-cycle toxicity, tests are labor resource intensive and, due an emphasis on apical endpoints, provide little no information about chemical mode action. Therefore,...
An approach for comparing laboratory and field measures of bioaccumulation is presented to facilitate the interpretation different sources data. Differences in numerical scales units are eliminated by converting data dimensionless fugacity (or concentration-normalized) ratios. The expresses metrics terms equilibrium status chemical, with respect a reference phase. When ratios plotted, degree variability within across easily visualized given chemical because their same all endpoints. Fugacity...
The mode of toxic action (MOA) is recognized as a key determinant chemical toxicity and an alternative to class-based predictive modeling. However, MOA classification has never been standardized in ecotoxicology, comprehensive comparison tools approaches reported. Here we critically evaluate three methodologies using aquatic data set 3448 chemicals, compare the approaches, assess utility limitations screening early tier assessments. comparisons focused on commonly used tools: Verhaar...
Our ability to conduct whole-organism toxicity tests understand chemical safety has been outpaced by the synthesis of new chemicals for a wide variety commercial applications. As result, scientists and risk assessors are turning mechanistically based studies increase efficiencies in assessment making greater use vitro silico methods evaluate potential environmental human health hazards. In this context, adverse outcome pathway (AOP) framework gained traction regulatory science because it...
Increases in botanical use, encompassing herbal medicines and dietary supplements, have underlined a critical need for an advancement safety assessment methodologies. However, botanicals present unique challenges due to their complex variable composition arising from diverse growing conditions, processing methods, plant varieties. Historically, been largely evaluated based on history of use information, primarily traditional or history. this presumption lacks comprehensive toxicological...
Animal alternative tests are gaining serious consideration in an array of environmental sciences, particularly as they relate to sound management chemicals and wastewater discharges. The ILSI Health Environmental Sciences Institute the European Centre for Ecotoxicology Toxicology Chemicals (ECETOC) held International Workshop on Application Fish Embryo Test March, 2008. This relatively young discipline is following advances animal alternatives human safety it advisable develop a broad...
Binding of hydrophobic chemicals to colloids such as proteins or lipids is difficult measure using classical microdialysis methods due low aqueous concentrations, adsorption dialysis membranes and test vessels, slow kinetics equilibration. Here, we employed a three-phase partitioning system where silicone (polydimethylsiloxane, PDMS) serves third phase determine between water acts at the same time dosing device for chemicals. The applicability this method was demonstrated with bovine serum...
Standard protocols are given for assessing metabolic stability in rainbow trout using the liver S9 fraction. These describe isolation of fractions from livers, evaluation a substrate depletion approach, and expression result as vivo intrinsic clearance. Additional guidance is provided on care handling test animals, design interpretation preliminary studies, development analytical methods. Although initially developed to predict metabolism impacts chemical accumulation by fish, these...
ABSTRACT European Union Directive 2013/39/EU, which amended and updated the Water Framework (WFD; 2000/60/EC) its daughter directive (2008/105/EC), sets Environmental Quality Standards for biota (EQS ) a number of bioaccumulative chemicals. These chemicals pose threat to both aquatic wildlife human health via consumption contaminated prey or intake food originating from environment. EU member states will need establish programs monitor concentration 11 priority substances in assess...