A5060220786- Prenatal Screening and Diagnostics
- Ethics and Legal Issues in Pediatric Healthcare
- Reproductive Health and Technologies
- Pluripotent Stem Cells Research
- Biomedical Ethics and Regulation
- Assisted Reproductive Technology and Twin Pregnancy
- Ethics in Clinical Research
- BRCA gene mutations in cancer
- Neuroethics, Human Enhancement, Biomedical Innovations
- Genomics and Rare Diseases
- CRISPR and Genetic Engineering
- Fetal and Pediatric Neurological Disorders
- Reproductive Biology and Fertility
- Organ Donation and Transplantation
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Cystic Fibrosis Research Advances
- Ethics in medical practice
- Genetic Neurodegenerative Diseases
- Child and Adolescent Psychosocial and Emotional Development
- Genomic variations and chromosomal abnormalities
- Demographic Trends and Gender Preferences
- Autism Spectrum Disorder Research
- Child and Adolescent Health
- Doping in Sports
Maastricht University
2015-2024
Vrije Universiteit Amsterdam
2020
Perinatal Institute
2013-2019
Personalis (United States)
2011-2018
MetaMetrics (United States)
2014-2015
Maastricht University Medical Centre
2008-2014
CSG Centre for Society and the Life Sciences
2012
Ghent University
2008-2011
University Medical Center Utrecht
2010
Ústav pro Péči o Matku a Dítě
2008
This paper contains a joint ESHG/ASHG position document with recommendations regarding responsible innovation in prenatal screening non-invasive testing (NIPT). By virtue of its greater accuracy and safety respect to for common autosomal aneuploidies, NIPT has the potential helping practice better achieve aim facilitating autonomous reproductive choices, provided that balanced pretest information non-directive counseling are available as part offer. Depending on health-care setting,...
This document of the European Society Human Genetics contains recommendations regarding responsible implementation expanded carrier screening. Carrier screening is defined here as detection status recessive diseases in couples or persons who do not have an a priori increased risk being based on their partners' personal family history. Expanded offers for multiple autosomal and X-linked disorders, facilitated by new genetic testing technologies, allows individuals regardless ancestry...
The recent introduction of oocyte vitrification has significantly advanced the outcome cryopreservation, leading to clinical results comparable those achieved in IVF using fresh oocytes, as reported by experienced centres. This lead new debate, both professional community and society at large, about acceptability offering this technology reproductively healthy women who want cryopreserve their oocytes against threat time. Given many demands calling for simultaneous realization a relatively...
If genome sequencing is performed in health care, theory the opportunity arises to take a further look at data: opportunistic genomic screening (OGS). The European Society of Human Genetics (ESHG) 2013 recommended that analysis should be restricted original problem least for time being. Other organizations have argued 'actionable' genetic variants or could reported (including American College Medical and Genomics, French Predictive Personalized Medicine, Genomics England). They argue used...
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as useful selecting the that carry least of disease later life. It appears at one child has been born after such a procedure. But utility PRS this respect is severely limited, and date, no clinical research performed assess its diagnostic effectiveness embryos. Patients need be properly informed limitations use PRSs, societal debate, focused what would...
Lifestyle is increasingly recognized as an outcome-determining factor in assisted reproduction, not only with regard to the cost-effectiveness but also view of balance benefits and risks, including risks related welfare future child. This document briefly summarizes evidence concerning impact three lifestyle-related factors (obesity, tobacco smoking alcohol consumption) on both natural reproduction (IVF) discusses implications this for practice medically light relevant ethical principles....
Gene editing, which allows for specific location(s) in the genome to be targeted and altered by deleting, adding or substituting nucleotides, is currently subject of important academic policy discussions. With advent efficient tools, such as CRISPR-Cas9, plausibility using gene editing safely humans either somatic germ line being considered seriously. Beyond safety issues, does raise ethical, legal social issues (ELSI), however, it suggested less challenging existing ethical frameworks;...
Technological developments in gene editing raise high expectations for clinical applications, including of the germline. The European Society Human Reproduction and Embryology (ESHRE) Genetics (ESHG) together developed a Background document Recommendations to inform stimulate ongoing societal debates. This provides background Recommendations. Germline is currently not allowed many countries. makes applications these countries impossible now, even if germline would become safe effective. What...
Abstract Expanded universal carrier screening ( EUCS ) entails a population‐wide offer for multiple disease‐causing mutations simultaneously. Although there is much debate about the conditions under which can responsibly be introduced, seems to little discussion its aim: providing couples with options autonomous reproductive choice. While this links in current accounts of aim foetal anomaly screening, it different from how ancestry‐based has traditionally been understood: reducing disease...
This Sounding Board article discusses the absence of data to support current widespread use preimplantation genetic testing for aneuploidy as an example a broader concern in reproductive medicine.
High-throughput sequencing technologies have increasingly led to discovery of disease-causing genetic variants, primarily in postnatal multi-cell DNA samples. However, applying these preimplantation testing (PGT) nuclear or mitochondrial from single few-cells biopsied vitro fertilised (IVF) embryos is challenging. PGT aims select IVF without abnormalities. Although genotyping-by-sequencing (GBS)-based haplotyping methods enabled for monogenic disorders (PGT-M), structural rearrangements...
In view of the global burden subfertility, efforts are required to make assisted reproduction more effective, less burdensome and equally accessible. New reproductive technologies frequently introduced in clinical practice without a sound evaluation their efficacy, effectiveness and/or safety. Safety issues this context refer both patients (mostly women) undergoing relevant medical procedures, health children born as result. Responsible innovation requires making potentially risky subject...
This Task Force document revisits the debate about ethics of sex selection for non-medical reasons in light relevant new technological developments. First, as a result improvement Microsort® flow cytometry method, there is now proven technique preconception that can be combined both with IVF and IUI. Secondly, scenario where approaches are currently being developed preimplantation genetic screening (PGS) may lead to such becoming routine part all treatment. In professionals will more often...
The introduction of genome-wide arrays in postnatal and prenatal diagnosis raises challenging ethical issues. Here, we explore questions with regard to the ethics consent. One important issue is whether informed consent for array-based testing fact feasible, given wide range possible outcomes related options. proposed alternative "generic consent" will have be studied practice. From an point view, question would still sufficiently "informed" a generic approach. Another that has not yet been...
What are the opinions of professionals in field genetics, reproductive science and metabolic diseases on development mitochondrial replacement technologies to be used context medically assisted reproduction? Although concerns regarding safety remain, interviewees supported nuclear transfer techniques help women who at risk transferring a DNA disease their offspring conceive genetically related child. Technological developments have sparked new interest debate acceptability use donor oocytes...
This Task Force document explores the ethical issues involved in debate about scope of genetic screening gamete donors. Calls for expanded donor arise against background both occasional findings serious but rare conditions donors or offspring that were not detected through present procedures and advent new genomic technologies promising affordable testing a wide range conditions. Ethical principles require all stakeholders' interests are taken into account, including those candidate The...
Justice and access are among the most urgent questions for medically assisted reproduction. This paper analyses this question not only people suffering from infertility, but also who need assistance to prevent birth of a child with specific genetic disorder. Based on impact being able have quality life person, position is defended that infertility treatment should be at least partially reimbursed. Simultaneously, medical professionals an obligation towards their patients health care system...
In March 2005, a group of experts from the European Society Human Genetics and Reproduction Embryology met to discuss interface between genetics assisted reproductive technology (ART), published an extended background paper, recommendations two Editorials. Seven years later, in 2012, follow-up interdisciplinary workshop was held, involving representatives both professional societies, including Union Eurogentest2 Coordination Action Project. The main goal this meeting developments at clinical...