A5008614521- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Erythrocyte Function and Pathophysiology
- Immune Cell Function and Interaction
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- RNA modifications and cancer
Instituto de Investigación de Enfermedades Raras
2022-2025
Instituto de Salud Carlos III
2022-2025
Instituto Murciano de Investigación Biosanitaria
2022-2025
Universidad de Murcia
2020-2025
Centre for Biomedical Network Research on Rare Diseases
2020-2025
Centro de Investigación Biomédica en Red
2020
Inflammasomes are critical components of the innate immune system, traditionally associated with pro-inflammatory responses. While inflammasome in macrophages has been extensively studied and linked to pyroptosis cytokine release, neutrophil remains poorly understood. Neutrophil activation drives unique outcomes such as NETosis robust IL-1β production without inducing pyroptosis. In contrast, macrophage promotes release cytokines like IL-1α IL-18. Here, using zebrafish models Salmonella...
Diamond-Blackfan Anemia Syndrome (DBAS) is characterized by impaired erythropoiesis due to dysfunctional ribosome biogenesis and aberrant cellular signaling. Here, we investigate how ribosomal stress-induced activation of the NLRP1 inflammasome modulates erythroid differentiation in DBAS. We demonstrate that FDA/EMA-approved tyrosine kinase inhibitors (TKIs) effectively mitigate defective anemia syndrome inhibiting activation. Specifically, nilotinib enhances K562 cells through suppression...
Abstract Chronic inflammatory diseases are associated with hematopoietic lineage bias, including neutrophilia and anemia. We have recently identified that the canonical inflammasome mediates cleavage of master erythroid transcription factor GATA1 in stem progenitor cells (HSPCs). report here genetic inhibition Nlrp1 resulted reduced number neutrophils increased erythrocyte counts zebrafish larvae. also found NLRP1 human was inhibited by LRRFIP1 FLII, independently DPP9, both inhibitors...