A5005433496- Tuberculosis Research and Epidemiology
- interferon and immune responses
- Biosensors and Analytical Detection
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Biochemical and Molecular Research
- Reproductive tract infections research
- Antibiotic Resistance in Bacteria
- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- Neonatal and Maternal Infections
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Inflammasome and immune disorders
- Immune responses and vaccinations
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Cancer therapeutics and mechanisms
Birla Institute of Technology and Science - Hyderabad Campus
2018-2024
Birla Institute of Technology and Science, Pilani
2023-2024
Translational Health Science and Technology Institute
2023
National Institute of Malaria Research
2023
Indian Council of Medical Research
2023
National Institute of Animal Biotechnology
2023
Weatherford College
2023
Johns Hopkins University
2015-2022
Johns Hopkins Medicine
2018-2022
Mucosa-associated invariant T (MAIT) cells are an important subset of innate lymphocytes that recognize microbial ligands derived from the riboflavin biosynthesis pathway and mediate antimicrobial immune responses. Modulated MAIT cell responses have been noted in different forms tuberculosis.
Abstract Background Stimulator of interferon genes (STING) is a key cytosolic receptor for small nucleotides and plays role in anticancer antiviral immunity. Cyclic dinucleotide STING agonists may comprise novel class vaccine adjuvants capable inducing cellular immune responses protective efficacy against intracellular pathogens. Methods We generated recombinant Bacillus Calmette-Guérin ([BCG] BCG-disA-OE) that overexpresses the endogenous mycobacterial diadenylate cyclase gene releases high...
Tuberculosis (TB) continues to be a global health crisis, necessitating urgent interventions address drug resistance and improve treatment efficacy. In this study, we validate lumazine synthase (RibH), vital enzyme in the riboflavin biosynthetic pathway, as potential target against Mycobacterium tuberculosis (M. tb) using CRISPRi-based conditional gene knockdown strategy. We employ high-throughput molecular docking approach screen ~ 600,000 compounds targeting RibH. Through vitro screening...
Tuberculosis poses a global health challenge, and it demands improved diagnostics therapies. Distinguishing between Mycobacterium tuberculosis (M. tb) bovis bovis) infections holds critical "One Health" significance due to the zoonotic nature of these inherent resistance M. pyrazinamide, key part directly observed treatment, short-course (DOTS) regimen. Furthermore, most currently used molecular detection methods fail distinguish two species. To address this, our study presents an innovative...
Our study addresses the growing concern posed by Klebsiella pneumoniae, a significant pathogen acknowledged World Health Organization (WHO). This bacterium is particularly alarming due to its association with antimicrobial resistance (AMR), impacting immunologically vulnerable populations, especially in hospital settings, and playing crucial role wound management. Moreover, this raises concerns maternal child health, being correlated adverse outcomes like pre-term birth, low birth weight,...
Detection pipeline for Klebsiella pneumoniae using RPA and AgNP.
Abstract Purpose Female infertility is a global health concern. The association of genital infections with female neglected due to their chronic but asymptomatic nature. Lack routine diagnosis and delay in treatment further causes intractable pathological sequalae consequential infertility. This study aims identify the most significant prognostic symptoms infection(s) that correlate strongly reproductive tract anomalies, menstrual disorders, Methods We designed detailed questionnaire...
ABSTRACT Stimulator of interferon genes (STING) has emerged as a key signaling receptor that induces proinflammatory cytokines, and small molecule STING agonists are being developed anticancer antiviral agents. Here we report strategy delivering agonist from within live BCG. We generated recombinant BCG (BCG- disA -OE) overexpresses the endogenous mycobacterial diadenylate cyclase gene releases high levels c-di-AMP. In macrophages BCG- -OE elicited statistically significantly stronger TNF-α,...
Abstract Tuberculosis (TB) continues to be a global health crisis, necessitating urgent interventions address drug resistance and improve treatment efficacy. In this study, we validate the indispensable role of lumazine synthase (RibH), vital enzyme in riboflavin biosynthetic pathway, survival Mycobacterium tuberculosis (M. tb) using CRISPRi-based conditional gene knockdown strategy. We show that genetic functional ablation RibH M. tb cannot compensated by exogenous supply Riboflavin, or...
Abstract Tuberculosis poses a global health challenge, demanding improved diagnostics and therapies. Distinguishing between Mycobacterium tuberculosis ( M. tb ) bovis infections holds critical “One Health” significance due to zoonotic nature of these inherent resistance pyrazinamide, key part Directly Observed Treatment, Short-course (DOTS) regimen. Furthermore, most the currently used molecular detection methods fail distinguish two species. To address this, our study presents an innovative...
Abstract Tuberculosis (TB) remains a pressing global health crisis, necessitating urgent interventions to combat drug resistance and improve treatment efficacy. In this study, we elucidate the essential role of lumazine synthase (RibH) for survival Mycobacterium tuberculosis (M. tb). Through CRISPRi-based gene knockdown in M. tb, confirm that deficiency RibH – penultimate enzyme riboflavin biosynthesis cannot be compensated by exogenous supply Riboflavin, FAD, or FMN. Further,...
Abstract Objectives Female infertility is a global health concern. The association of genital infections with female neglected due to their chronic but asymptomatic nature. Lack routine diagnosis and delay in treatment further causes intractable pathological sequalae consequential infertility. This study aims identify the most significant prognostic symptoms infection(s) that correlate strongly reproductive tract anomalies, menstrual disorders, Methods We designed detailed questionnaire...