Organ printing is a novel concept recently introduced in developing artificial three-dimensional organs to bridge the gap between transplantation needs and organ shortage. One of major challenges inclusion blood-vessellike channels layers support cell viability, postprinting functionality terms nutrient transport, waste removal. In this research, we developed effective method print tubular encapsulating cells alginate mimic natural vascular system. An experimental investigation into...

Tissue engineering has been a promising field of research, offering hope bridging the gap between organ shortage and transplantation needs. However, building three-dimensional (3D) vascularized organs remains main technological barrier to be overcome. One major challenges is inclusion vascular network support cell viability in terms nutrients oxygen perfusion. This paper introduces new approach fabrication vessel-like microfluidic channels that potential used thick tissue or future. In this...

The ability to create three dimensional (3D) thick tissues is still a major tissue engineering challenge. It requires the development of suitable vascular supply for an efficient media exchange. An integrated vasculature network particularly needed when building functional and/or organs with high metabolic activities, such as heart, liver and pancreas. In this work, human umbilical vein smooth muscle cells (HUVSMCs) were encapsulated in sodium alginate printed form conduits using coaxial...

Abstract The development of novel photosensitizers (PSs) with aggregation‐induced emission (AIE) properties has emerged as a crucial advancement in the field photodynamic therapy (PDT). However, versatile applications AIE PSs are limited by low encapsulation efficiency and inadequate target tissue permeability. Biomimetic technology stands out promising strategy to overcome these challenges, aiming enhance tumor penetration efficacy, their association antitumor immune responses. In this...

Despite the progress in tissue engineering, several challenges must be addressed for organ printing to become a reality. The most critical challenge is integration of vascular network, which also problem that majority engineering technologies are facing. An embedded microfluidic channel network probably promising solution this problem. However, available fabrication either have difficulty achieving three-dimensional complex structure or difficult integrate within cell process tandem. In...

Vascularization of thick engineered tissue and organ constructs like the heart, liver, pancreas or kidney remains a major challenge in engineering. is needed to supply oxygen nutrients remove waste living tissues organs through network that should possess high perfusion ability significant mechanical strength elasticity. In this paper, we introduce fabrication process print vascular conduits directly, where were reinforced with carbon nanotubes (CNTs) enhance their properties...

Tissue engineering has been focused on the fabrication of vascularized 3D tissue for decades. Most recently, bioprinting, especially and organ printing, shown great potential to enable automated robotic-based tissues organs that are readily available in vitro studies or vivo transplantation. Studies have demonstrated feasibility printing process through bioprinting scaffold-free cellular constructs able undergo self-assembly formation; however, they still limited size thickness due lack a...

In this paper, a mathematical model and an improved imperial competition algorithm (IICA) are proposed to solve the multi-objective two-sided assembly line rebalancing problem with space resource restrictions (MTALRBP-SR). The aim is find lines' rebalance trade-off between efficiency, cost smoothing after reconfiguration. IICA utilises new initialisation heuristic procedure based on classic rules generate feasible initial solutions. A novel assimilation method developed vigorously conduct...

Developing efficient photosensitizers (PSs) that can generate type I reactive oxygen species (ROS) under illumination is considered an effective way to improve photodynamic therapy (PDT) outcomes due the hypoxic nature of tumor environment, but also very challenging. Herein, a new PS multiarylpyrrole (MAP) derivative with typical donor-acceptor structure was synthesized efficiently ROS by using acceptor-shielding strategy in their aggregated state. The enhanced generation mechanism...

This article deals with a real-life multi-objective two-sided assembly line rebalancing problem (MTALRBP) modifications of production demand, line's structure and process in Chinese construction machinery manufacturing firm. The objectives are minimising the cycle time cost, considering some specific constraints associated inevitable wait time, such as novel idle balanced constraints. A modified non-dominated sorting genetic algorithm II (MNSGA-II) is proposed to solve this problem. MNSGA-II...

ABSTRACT The starch/polyvinyl alcohol (PVA) bioblend sheets containing urea and formamide as plasticizers were prepared through melt processing in presence of water. experiments indicated that could form strong hydrogen bonds with starch/PVA molecules. Urea exhibited better plasticizing effect than formamide. also greatly destroy the crystal structures PVA component blends, leading to decreased crystallinity blends. Formamide was a good solvent for prevent separating from resulting improved...

In this work, we took advantage of a one-pot reaction to prepare tumor-targeting nanoparticles (Au@T), which could respond the intracellular acidic environment and form aggregates enhance retention effect in tumor cells, for dual-mode diagnose photothermal therapy.

Zwitterionic chitooligosaccharide-modified BTC NPs can re-educate TAMs to a tumoricidal M1 subtype, thus improving the antitumor effect of PTT.

Turbines are typical engineering-to-order products which can be highly customized. This paper considers the final assembly control under uncertainty in turbine workstations. A cyber-physical framework based on Internet of Things (IoT) is proposed for assembly, consists physical components, cyber components and an IoT-based monitoring system. The modules capture real-time data including workers, tools, parts actual process. These generate original scheduling tasks, re-sequence re-assign...

In practical production, the balance of assembly lines is always destroyed by many factors, e.g., demand fluctuations, disruptions caused workstation breakdowns or shutdowns, and changes work force. Therefore, this paper addresses type II rebalancing problem for two-sided (TALRBP-II), which are widely utilized to assemble large-size high-volume products. As we all know that TALBP-II (two-sided line balancing type-II) NP-hard, TALRBP-II its extension much more complex. order solve problem, a...

The goal of virtual orthodontic treatment planning is to re-position the teeth in a digital dental model so that desired alignment on each arch and occlusion (i.e., matching) upper lower arches achieved.The input process collection individual tooth objects obtained by segmenting noisy 3D surface mesh generated laserscanning plaster built from patient-specific impressions.A key step identification features such as cusps, grooves, incisal edges, marginal ridges, occlusal boundary, are...

As an indispensable part of the automobile factory transmission system, assembly line has a high level automation and can play as pioneer in digital transformation production. However, for production process, especially front middle case, there are many problems, such low degree informatization, efficiency information transmission, lack platform rapid release sharing. This leads to difficulty timely discovery feedback exceptional events, resulting efficiency. Therefore, this paper constructs...