A5036038614- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Olfactory and Sensory Function Studies
- Insect and Pesticide Research
- Cholinesterase and Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Photochromic and Fluorescence Chemistry
- Hearing, Cochlea, Tinnitus, Genetics
Johnson & Johnson (United States)
2016-2021
Janssen (United States)
2016-2021
Scripps Research Institute
2017
University of California, San Diego
2017
Janssen (Belgium)
2017
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral addictive properties nicotine. nAChRs derive from combinations α β subunits, whose assembly is tightly regulated. NACHO was recently identified as a chaperone for α7-type nAChRs. Here, we find mediates all major classes presynaptic postsynaptic nAChR tested. acts at early intracellular stages subunit then synergizes with RIC-3 receptor surface expression. knockout mice...
Highlights•Reconstituting α6-containing nACh receptors requires multiple accessory components•NACHO protein mediates assembly of receptors•BARP controls gating receptors•LAMP5 and SULT2B1 proteins enhance surface trafficking nAChRsSummaryAcetylcholine gates a large family nicotinic receptor cation channels that control neuronal excitation neurotransmitter release. These are key targets for neuropsychiatric disorders; however, difficulties in expressing acetylcholine (nACh) hamper elaboration...
Significance Auditory hair cells receive olivocochlear efferent innervation, which improves sound discrimination and mitigates acoustic trauma. The synapse involves α9α10 nicotinic acetylcholine receptors (nAChRs), do not express in recombinant cell lines. Here, genome-wide screening determined that assembly surface expression of require ligand binding. Ion channel function additionally demands an auxiliary subunit, can be transmembrane inner ear (TMIE) or TMEM132e. These single-pass...
Abstract Olfactory circuits function at birth, yet are continuously remodeled through the integration of adult-born interneurons into olfactory bulb in a manner that preserves perceptual stability throughout adult life. The mechanisms ensure appropriate circuit this dynamic context remain poorly understood. Since sculpt excitatory output mitral and tufted (MT) neurons to cortex, we predicted MT might instruct interneuron wiring brain. By blocking synaptic transmission from show neuronal...