A5023559592- CAR-T cell therapy research
- Glioma Diagnosis and Treatment
- Cell Image Analysis Techniques
- Nanowire Synthesis and Applications
- Pluripotent Stem Cells Research
- Single-cell and spatial transcriptomics
- 3D Printing in Biomedical Research
- Mitochondrial Function and Pathology
- Melanoma and MAPK Pathways
- Immune cells in cancer
- Immune Cell Function and Interaction
- Biosimilars and Bioanalytical Methods
- Computational Drug Discovery Methods
- Radiopharmaceutical Chemistry and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- Olfactory and Sensory Function Studies
- T-cell and B-cell Immunology
- Brain Metastases and Treatment
- Ferroptosis and cancer prognosis
- Protein Kinase Regulation and GTPase Signaling
- Neuroscience and Neural Engineering
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
ETH Zurich
2020-2024
The Geneva Association
2022
Scripps Research Institute
2013-2018
Glioblastoma (GBM) is the most aggressive form of primary brain tumor, for which effective therapies are urgently needed. Cancer cells capable evading clearance by phagocytes such as microglia- and monocyte-derived through engaging tolerogenic programs. Here, we found that high expression sialic acid–binding immunoglobulin-like lectin 9 (Siglec-9) correlates with reduced survival in patients GBM. Using cell-specific knockouts Siglec-E, murine functional homolog Siglec-9, together single-cell...
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, cell cycle. Despite the critical role in cells their strong association with diseases, good coverage interactions is available only a fraction 535 human kinases. Here, we present comprehensive mass-spectrometry-based analysis kinase interaction network covering more than 300 The dataset high-quality resource 5,000 previously unreported...
Abstract Purpose: Most chimeric antigen receptor (CAR) T-cell strategies against glioblastoma have demonstrated only modest therapeutic activity and are based on persistent gene modification that limited transgene capacity, long manufacturing processes, the risk for uncontrollable off-tumor toxicities. mRNA-based modifications an emerging safe, rapid, cost-effective alternative to overcome these challenges, but underexplored glioblastoma. Experimental Design: We generated mouse human...
After antigen stimulation, naïve T cells display reproducible population-level responses, which arise from individual pursuing specific differentiation trajectories. However, cell-intrinsic predeterminants controlling these single-cell decisions remain enigmatic. We found that the subcellular architectures of CD8 cells, defined by presence (T
The use of computational tools to identify biological targets natural products with anticancer properties and unknown modes action is gaining momentum. We employed self-organizing maps deconvolute the phenotypic effects piperlongumine (PL) establish a link modulation human transient receptor potential vanilloid 2 (hTRPV2) channel. structure PL-bound full-length rat TRPV2 channel was determined by cryo-EM. PL binds allosteric pocket responsible for new mode activity against glioblastoma (GBM)...
Abstract Characterising cellular phenotypic heterogeneity is essential to understand the relationship between molecular and morphological determinants of state. Here we report that publicly available self-supervised vision transformers (ss-ViTs) accurately elucidate stem cell out-of-the-box. Moreover, introduce scDINO, an adapted ss-ViT trained on five-channel automated microscopy data, attaining excellent performance in delineating peripheral blood immune identity. Thus, ss-ViTs represent a...
Abstract Brain metastases remain a common and important complication in the course of disease patients with non-small cell lung cancer (NSCLC). While targeted therapies immunotherapies have led to prolonged control subsets brain from NSCLC, there is still an urgent need for novel treatments after failure these standards exhaustion local including surgery radiotherapy. Here we performed explorative feasibility study profile ex vivo drug sensitivities across large panel classical anti-cancer...
Abstract BACKGROUND Glioblastoma is the most common malignant primary brain tumor in adults, characterized by poor overall survival and an urgent need for more effective treatment strategies. Macroscopic heterogeneity, as observed through MR imaging, divides into distinct regions: a tumor-cell dense contrast-enhancing core non-contrast-enhancing infiltration zone that appears hyperintense on T2/FLAIR imaging. The contains both infiltrating cells non-malignant from local microenvironment....
Journal Article Corrected proof Next step towards functional precision medicine in neuro-oncology Get access Tobias Weiss, Weiss Department of Neurology, Clinical Neuroscience Center, University Hospital and Zurich, Switzerland Corresponding Author: MD, PhD, Zurich Frauenklinikstrasse 26, 8091 ([email protected]). https://orcid.org/0000-0002-5533-9429 Search for other works by this author on: Oxford Academic PubMed Google Scholar Sohyon Lee, Lee Institute Molecular Systems Biology, ETH...
Abstract Olfactory circuits function at birth, yet are continuously remodeled through the integration of adult-born interneurons into olfactory bulb in a manner that preserves perceptual stability throughout adult life. The mechanisms ensure appropriate circuit this dynamic context remain poorly understood. Since sculpt excitatory output mitral and tufted (MT) neurons to cortex, we predicted MT might instruct interneuron wiring brain. By blocking synaptic transmission from show neuronal...
Abstract Glioblastoma (GBM) is the most aggressive form of primary brain tumor, for which effective therapies are urgently needed. Cancer cells capable evading clearance by phagocytes such as microglia and monocyte-derived through engaging tolerogenic programs. Here, we found that high level Siglec-9 expression correlates with reduced survival in GBM patients. Using conditional knockouts Siglec-E, murine functional homologue Siglec-9, together single-cell RNA sequencing, demonstrated...
Abstract Glioblastoma is the most common yet deadliest primary brain cancer 1 . The neural behavior of glioblastoma, including formation synaptic circuitry and tumour microtubes, increasingly understood to be pivotal for disease manifestation 2–9 Nonetheless, few approved treatments glioblastoma target its oncological nature, while vulnerabilities remain incompletely mapped clinically unexploited. Here, we systematically survey molecular dependencies cellular heterogeneity across patients...
Supplementary Figure from Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma
Supplementary Data from Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma
Supplementary Figure from Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma
Supplementary Figure from Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma
Supplementary Figure from Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma
<div>AbstractPurpose:<p>Most chimeric antigen receptor (CAR) T-cell strategies against glioblastoma have demonstrated only modest therapeutic activity and are based on persistent gene modification that limited transgene capacity, long manufacturing processes, the risk for uncontrollable off-tumor toxicities. mRNA-based modifications an emerging safe, rapid, cost-effective alternative to overcome these challenges, but underexplored glioblastoma.</p>Experimental...
Supplementary Figure from Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma
<div>AbstractPurpose:<p>Most chimeric antigen receptor (CAR) T-cell strategies against glioblastoma have demonstrated only modest therapeutic activity and are based on persistent gene modification that limited transgene capacity, long manufacturing processes, the risk for uncontrollable off-tumor toxicities. mRNA-based modifications an emerging safe, rapid, cost-effective alternative to overcome these challenges, but underexplored glioblastoma.</p>Experimental...