A5022355905- Research on Leishmaniasis Studies
- Ocular Infections and Treatments
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Ocular Diseases and Behçet’s Syndrome
- Advanced Chemical Sensor Technologies
- Retinopathy of Prematurity Studies
- Corneal Surgery and Treatments
- Antifungal resistance and susceptibility
- Veterinary medicine and infectious diseases
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Drug-Induced Ocular Toxicity
- Protease and Inhibitor Mechanisms
- Biochemical and Molecular Research
- Metabolism and Genetic Disorders
- Insect and Pesticide Research
- Corneal surgery and disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Antimicrobial agents and applications
- Synthesis and biological activity
London School of Hygiene & Tropical Medicine
2012-2024
University of Edinburgh
2024
Aravind Eye Hospital
2024
University College London
2012-2018
National Institute for Health Research
2017
Medway School of Pharmacy
2017
The London College
2017
Moorfields Eye Hospital NHS Foundation Trust
2017
Moorfields Eye Hospital
2013
University of London
2012
<ns3:p>Purpose To determine the knowledge, attitude, and practice of pharmacy attendants in management microbial keratitis. Methods This mixed-methods study was conducted selected pharmacies drug shops located Mbarara City between March May 2022. We administered questionnaires assessing attitudes, practices (KAP) related to keratitis (MK) 140 (PAs) pharmacies. also 40 in-depth interviews (IDI) three focus group discussions (FGD) with discuss practices, challenges, opportunities improve MK....
A noncovalent complex of amphotericin B (AmB) and poly(α-glutamic acid) (PGA) was prepared to develop a safe stable formulation for the treatment leishmaniasis. The loading AmB in range ∼20–50%. highly aggregated state with an aggregation ratio often above 2.0. This (AmB–PGA) shown be have reduced toxicity human red blood cells KB compared parent compound; cell viability not affected at concentration as high 50 200 μg/mL respectively. AmB–PGA retained activity against intracellular...
To assess the pyridoxal 5'-phosphate (PLP) content and stability of extemporaneous PLP liquids prepared from dietary supplements used for treatment vitamin B6 -dependent epilepsy.Pyridoxal were in accordance with guidelines given to patients marketed 50 mg capsules tablets. The its evaluated under conditions resembling clinical setting using reverse phase HPLC mass spectrometry.Pyridoxal most extemporaneously was found be different expected amount (~16-60 mg). Most these stable at room...
A noncovalent, water-soluble complex of amphotericin B (AMB) and poly(α-glutamic acid) (PGA), with AMB loadings ranging from 25 to 55% (wt/wt) using PGA a molecular weight range 50,000 70,000, was prepared as potential new treatment for visceral leishmaniasis (VL). The AMB-PGA shown be active Fungizone (AMB deoxycholate) against intracellular Leishmania donovani amastigotes in differentiated THP-1 cells. vitro uptake the by cells similar that higher than AmBisome (liposomal AMB). also...
Fungal keratitis is a major ophthalmic public health problem, particularly in low-income and middle-income countries. The options for treating fungal are limited. Our study aimed to describe the outcomes of using chlorhexidine 0.2% eye-drops as additional treatment management patients with recalcitrant keratitis.
Purpose: The purpose of this study was to develop a topical matrix metalloproteinase inhibitor preparation for antiscarring therapy. Methods: broad spectrum ilomastat formulated using 2-hydroxypropyl-β-cyclodextrin in aqueous solution. In vitro activity ilomastat-cyclodextrin (ilomastat-CD) examined fibroblasts seeded collagen. Permeation ilomastat-CD eye drop through pig conjunctiva confirmed Franz diffusion cells. Ilomastat-CD applied rabbit eyes vivo, and the distribution ocular tissues...
Amphotericin B (AmB) is used to treat a neglected disease called visceral leishmaniasis (VL). We hypothesised that direct non-covalent association of AmB with poly(methacrylic acid) (PMAA) would replicate many the properties liposomal (AmB-L), which more efficacious than micellar (AmB-D). Water-soluble AmB–PMAA complexes loadings ranging from ∼20 45% were reproducibly prepared. The in PMAA complex displayed similar aggregation within AmB-L. low heamolytic while maintaining vitro activity...
Purpose: The purpose of this study was to develop a protocol prepare buffered chlorhexidine (CHX) eye drops (0.2% w/v) in the United Kingdom that can be reproduced at production facility Uganda. Buffered CHX prevent degradation and improve ocular tolerability during treatment fungal keratitis. Methods: amber glass containers were prepared using sodium acetate buffer pH 5.90 6.75. Two commercial solutions water used as controls. Eye stored 40°C (70% humidity, 21 months) ambient temperature...
A copolymer was used as a platform for solubilisation of an anti-leishmanial agent. non-covalent complex amphotericin B (AmB) and poly(vinylpyrrolidone-co-methacrylic acid) (PVM) sodium salt prepared from N-hydroxysuccinimide (NHS) active ester precursor polymer in effort to improve the therapeutic index AmB. Leishmaniasis is neglected disease that can be effectively treated with Unfortunately AmB poorly soluble highly prone aggregation degradation. It also toxic lipid formulations mediate...
<ns3:p>Background Microbial Keratitis (MK) is a leading cause of corneal blindness due to infection and its consequences, with higher incidence in resource-limited nations. Hospital-based patient records from different parts Nepal suggest patients often use traditional eye medicine treat MK. Traditional healers (TH) within the community are first point care for MK management. Little known their practice, perceptions, knowledge around We aimed understand role management south-eastern Nepal....
<ns3:p>Background Microbial Keratitis (MK) is a leading cause of corneal blindness due to infection and its consequences, with higher incidence in resource-limited nations. Hospital-based patient records from different parts Nepal suggest patients often use traditional eye medicine treat MK. Traditional healers (TH) within the community are first point care for MK management. Little known their practice, perceptions, knowledge around We aimed understand role management south-eastern Nepal....