The plexiform lesion is the hallmark of severe pulmonary arterial hypertension. However, its genesis and hemodynamic effects are largely unknown because limited availability lung tissue samples from patients with hypertension lack appropriate animal models. This study investigated whether rats progressive developed lesions. After a single subcutaneous injection vascular endothelial growth factor receptor blocker Sugen 5416, were exposed to hypoxia for 3 weeks. They then returned normoxia an...

Current therapy of pulmonary arterial hypertension (PAH) is inadequate. Dehydroepiandrosterone (DHEA) effectively treats experimental in chronically hypoxic and monocrotaline-injected rats. Contrary to these animal models, SU5416/hypoxia/normoxia-exposed rats develop a more severe form occlusive arteriopathy right ventricular (RV) dysfunction that indistinguishable from the human disorder. Thus, we tested effects DHEA treatment on PAH RV structure function this model. Chronic (5 wk)...

We have investigated the temporal relationship between hemodynamic and histological/morphological progression in a rat model of pulmonary arterial hypertension that develops lesions morphologically indistinguishable from those human hypertension. Adult male rats were injected with Sugen5416 exposed to hypoxia for 3 wk followed by return normoxia various additional weeks. At 1, 3, 5, 8, 13 after injection, histological examinations performed. Right ventricular systolic pressure reached its...

Pulmonary arterial hypertension (PAH) is a debilitating and deadly disease with no known cure. Heart failure major comorbidity common cause of the premature death patients PAH. Increased asymmetrical right ventricular hypertrophy septal wall thickening compress left cavity elicit diastolic heart failure. In this study, we used Sugen5416/hypoxia/normoxia-induced PAH rat to determine whether altered pyridine nucleotide signaling in failing contributes 1) increased oxidative stress, 2) changes...

A major limitation in the pharmacological treatment of pulmonary arterial hypertension (PAH) is lack vascular selectivity. Recent studies have identified a tissue-penetrating homing peptide, CARSKNKDC (CAR), which specifically homes to hypertensive arteries but not normal vessels or other tissues. Some peptides unique ability facilitate transport co-administered drugs into targeted cells/tissues without requiring physical conjugation drug peptide (bystander effect). We tested hypothesis that...

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COVID-19 has posed an unprecedented global public health threat and caused a significant number of severe cases that necessitated long hospitalization overwhelmed services in the most affected countries. In response, governments initiated series non-pharmaceutical interventions (NPIs) led to economic social impacts. The effect these intervention measures on spread pandemic are not well investigated within developing country settings. This study simulated trajectories curve Jordan between...

Gitelman syndrome is a rare autosomal recessive disorder that affects the distal convoluted tubules of kidneys. It often manifests through various symptoms, including muscle weakness, paresthesia, fatigue, or paralysis. Owing to scarcity case reports regarding in Middle East and North Africa region, it imperative spread awareness about this for prompt diagnosis. Consequently, could drastically decrease rate complications help with its management prognosis. This report addresses lack...

Abstract This article investigates aspects of stress assignment in a Jordanian Arabic dialect (JA). Cases opaque are discussed with reference to Harmonic Serialism (HS) within the framework Optimality Theory (OT). Two sources under consideration. On one hand, syllable an antepenultimate position is stressed where Heavy penultimate expected receive stress. other light All cases involve epenthetic vowel or ultimate two structures, respectively. An account such structures requires faithfulness...

Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary pressure with lumen-occluding neointimal and plexiform lesions. Activation of store-operated calcium entry channels promotes contraction proliferation lung vascular cells. TRPC4 a ubiquitously expressed channel, but its role in PAH unknown. We tested the hypothesis that constriction occlusive remodeling, leading to right ventricular failure severe PAH. Severe was induced Sprague-Dawley rats wild-type TRPC4-knockout...

Although hypoxia is detrimental to most cell types, it aids survival of progenitor cells and associated with diseases like cancer pulmonary hypertension in humans. Therefore, understanding the underlying mechanisms that promote then developing novel therapies stop their growth hypoxia-associated human important. Here we demonstrate proliferation CD133(+) cells, which contribute tumorigenesis development hypertension, are increased when cultured under hypoxic conditions. Furthermore,...

Background: Waterpipe tobacco smoking (WTS) emerges as a new component of the global epidemic. Adolescents waterpipe are susceptible to cigarette smoking, but limited research has characterized dual (cigarette plus waterpipe) users. The study objective is determine prevalence estimates users understand how "collision" two epidemics evolving in Arab countries.Methods: Data (n = 31,359; N 6,109,572) were obtained from nationally representative Global Youth Tobacco Surveys (GYTSs) 17 countries....

Idiopathic male infertility is evident in half of infertile males. Vitamin D receptors are expressed throughout reproductive tract, including spermatozoa, promoting motility. Epidemiological studies revealed the positive association between serum vitamin and semen quality. However, there no clinical examining differential role idiopathic infertility.1) To investigate deficiency infertility, 2) determine whether deficient males would show restoration quality parameters upon supplementation...

Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in treatment of morbid obesity. However, little known about underlying molecular pathways modulated by these interventions. Since leptin resistance implicated pathogenesis obesity, we herein report effects laparoscopic sleeve gastrectomy (LSG) on serum levels receptor, addition to its overall effect resistance. This was an interventional follow-up clinical...

Little is known about tobacco use among youth exposed to armed conflicts, or the influence of trauma on in this context. This study examined patterns smoking by product and gender Syrian refugee living host communities Jordan assessed associations post-traumatic stress disorder (PTSD) depression symptoms, exposure social support with current status boys girls.Syrian students (mean [standard deviation] age = 14.9 [1.33] years) were identified through public school system. Data collected using...

Abstract Background: COVID-19 has posed an unprecedented global public health threat and caused a significant number of severe cases that necessitated long hospitalization overwhelmed the services in most affected countries. In response, governments initiated series non-pharmaceutical interventions (NPIs) led to economic social impacts. The effect these intervention measures on spread pandemic are not well investigated within developing countries settings. This study simulated trajectories...

BACKGROUND Pharmacogenomics (PG) is a modern tool of personalising treatment protocols to improve the efficacy and safety drug prescriptions. These benefits are offset by slow uptake in clinical application due host physician factors, patient factors and/or health system factors. Our study, thus, aimed determine knowledge, attitude, future expectations perceived barriers medical students physicians Jordan regarding PG testing. METHODS A descriptive, cross-sectional study was conducted...

Background Substantial evidence supports a bidirectional relationship between diabetes and clinical depression. However, little is known about the effect of treating one condition on control other. Thus, this study aimed to determine prevalence depression among Type II mellitus (T2DM) patients assess efficacy feasibility escitalopram treatment their metabolic parameters. Methods T2DM attending primary care clinics in North Jordan were enrolled cross-sectional during period from February...

Precision oncology and pharmacogenomics (PGx) intersect in their overarching goal to institute the right treatment for patient. However, translation of these innovations into clinical practice is still lagging behind. Therefore, this study aimed analyze current state research predict future directions applied PGx field precision as represented by targeted therapy class tyrosine kinase inhibitors (TKIs). Advanced bibliometric scientometric analyses literature were performed. The Scopus...

Background: Although we are four years into the pandemic, there is still conflicting evidence regarding clinical outcomes of diabetic patients hospitalized with COVID-19. The primary objective this study was to evaluate in-hospital mortality and morbidity versus nondiabetic COVID-19 in Northern UAE Emirates. Methods: A retrospective analysis performed on data from or without diabetes mellitus (DM) who were admitted isolation hospital during first second waves disease (March 2020 April 2021)....

Background: Chronic obstructive pulmonary disease (COPD) is marked by destruction of alveolar architecture. Preclinical modelling for COPD challenging. cigarette smoke exposure, the reference animal model COPD, time-inefficient, while exposure to waterpipe (WPS), a surging smoking modality, was not fully tested its histopathological consequences. Since damage and vascular endothelial dysfunction are integral pathology, lung effects WPS were temporally evaluated, alone or in combination with...