A5101786131- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Polysaccharides Composition and Applications
- Hedgehog Signaling Pathway Studies
- Food composition and properties
- Botanical Research and Applications
- Microbial Metabolic Engineering and Bioproduction
- Ferroptosis and cancer prognosis
- Head and Neck Cancer Studies
Sichuan Cancer Hospital
2020-2024
University of Electronic Science and Technology of China
2024
Johns Hopkins University
2021
Johns Hopkins Medicine
2021
Tongji Hospital
2018-2020
Jilin University
2017-2020
Huazhong University of Science and Technology
2018-2020
First Hospital of Jilin University
2017-2020
Glioma is a worldwide malignancy, which displays significantly active metastasis and angiogenesis.Interaction between long non-coding RNAs (lncRNAs) microRNAs (miRNAs) has been shown to play crucial role in regulating tumor properties.However, the potential of lncRNA X-inactive specific transcript (XIST) function as miRNA regulator its relevance glioma tumorigenicity angiogenesis have so far remained unclear.Expression analysis XIST cells revealed significant up-regulation.Interestingly,...
Abstract Hepatocellular carcinoma ( HCC ) is an invasive malignant tumour and the second major cause of cancer‐related deaths over world. CRNDE miR‐217 are non‐coding RNA s which play critical roles in cell growth, proliferation, migration. Mitogen‐activated protein kinase 1 MAPK also participates cancer process. Hence, this study aimed at investigating effect on migration invasion figuring out role The overexpression was demonstrated by a microarray‐based lnc profiling study. expression...
Abstract DNA methylation, an epigenetic regulatory mechanism dictating gene transcription, plays a critical role in the occurrence and development of cancer. However, molecular underpinnings LINC00987 methylation regulation lung adenocarcinoma (LUAD) remain elusive. This study investigated expression LUAD patients through analysis The Cancer Genome Atlas data sets. Quantitative real‐time polymerase chain reaction (RT‐qPCR) fluorescence situ hybridization assays were used to assess LUAD....
Abstract Background Lung adenocarcinoma (LAD) is a highly aggressive malignant tumor which threatens the health and life of population. Long non‐coding RNA X‐inactive specific transcript (XIST) mouse double minute clone 2 (MDM2) are connected with tumorigenesis LAD. Nevertheless, whether MDM2 regulated by XIST has not previously been reported in Methods Quantitative real‐time polymerase chain reaction (qRT‐PCR) was employed to detect expression XIST, microRNA‐363‐3p (miR‐363‐3p) LAD tissues...
Abstract Hepatocellular carcinoma (HCC) is a main cause of cancer‐related deaths globally. Long non‐coding RNAs (lncRNAs) play important roles in diverse cancers. Our previous microarray‐based lncRNA profiling showed that LINC00467 was highly expressed HCC. Here, we further explored the expression, role and functional mechanism findings revealed up‐regulated HCC tissues cell lines. Increased expression positively associated with tumour size vascular invasion. In vitro experiments accelerated...
Barrett’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of biological pathways. However, involvement lncRNAs in the development BE and EAC has not well-studied. The aims current study were: (1) lncRNA, miR205HG, EAC; (2) clarify role miR205HG vitro vivo experiments; (3) investigate mechanism involving Hedgehog (Hh) signaling pathway. These experiments revealed that was downregulated vs. normal...
Long noncoding RNA LINRIS (LINC00920) is known to participate in colorectal cancer. This study aimed explore the role of non-small cell lung cancer (NSCLC). NSCLC and adjacent non-tumor tissues were collected from 62 patients. expression was detected using real-time quantitative PCR (RT-qPCRs). The patients monitored every month for 5 years evaluate predicting prognosis NSCLC. effects silencing on microRNA-10a (miR-10a) precursor mature miR-10a levels assessed by RT-qPCR. Cell proliferation...
Abstract According to statistics, abnormal regulation of lncRNAs pivotally influences multiple malignant tumours. DLEU2 , as one these lncRNAs, is detected be related growth and development The molecular mechanisms in osteosarcoma, however, are still unknown. QRT‐PCR was adopted analyse the correlations clinicopathological features prognosis osteosarcoma cases with . on cell migration viability were evaluated independently by experiments vitro vivo. Bioinformatics analysis, RNA...
Backgrounds: LncRNA long intergenic non-protein coding RNA p53 induced transcript (LINC-PINT) is downregulated in multiple types of cancer cells. The authors explored the possible involvement LINC-PINT esophageal squamous cell carcinoma (ESCC). Materials and Methods: Sixty-two patients with early-stage ESCC were included this study. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect gene expression plasma from healthy controls. Diagnostic analysis performed by...