A5052066627- Epigenetics and DNA Methylation
- Polyomavirus and related diseases
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Hair Growth and Disorders
- Plant Gene Expression Analysis
- Hedgehog Signaling Pathway Studies
- Extracellular vesicles in disease
- DNA Repair Mechanisms
- Tissue Engineering and Regenerative Medicine
- Cleft Lip and Palate Research
- Skin Protection and Aging
- Cancer and Skin Lesions
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
- melanin and skin pigmentation
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Cancer-related Molecular Pathways
- Tumors and Oncological Cases
Icahn School of Medicine at Mount Sinai
2016-2021
Weizmann Institute of Science
2015
An increasing amount of evidence indicates that developmental programs are tightly regulated by the complex interplay between signaling pathways, as well transcriptional and epigenetic processes. Here, we have uncovered coordination morphogen cues to specify Merkel cells, poorly understood skin cells mediate light touch sensations. In murine dorsal skin, part domes, which structures consisting specialized keratinocytes, afferent neurons, located exclusively around primary hair follicles. We...
Polycomb repressive complex 1 (PRC1) and PRC2 are critical epigenetic developmental regulators. PRC1 largely overlap in their genomic binding cooperate to establish chromatin domains demarcated by H2AK119ub H3K27me3. However, the functional contribution of each gene repression has been a subject debate, understanding its physiological significance requires further studies. Here, using developing murine epidermis as paradigm, we uncovered previously unappreciated redundancy between complexes....
Merkel cells are innervated mechanosensory responsible for light-touch sensations. In murine dorsal skin, located in touch domes and found the epidermis around primary hairs. While it has been shown that skin epithelial cells, progenitor cell population gives rise to these is unknown. Here, we show during embryogenesis, SOX9-positive (+) inside hair follicles, which were previously known give follicle stem (HFSCs) of lineage, can also Cells. Interestingly, while SOX9 critical HFSC...
Abstract DNA-damage tolerance (DDT) via translesion DNA synthesis (TLS) or homology-dependent repair (HDR) functions to bypass lesions encountered during replication, and is critical for maintaining genome stability. Here, we present piggyBlock, a new chromosomal assay that, using piggyBac transposition of containing known lesion, measures the division labor between two DDT pathways. We show that in absence damage response, most common sunlight-induced TT-CPD, achieved by TLS mouse embryo...
How tissue patterns are formed and maintained fundamental questions. The murine tongue epithelium, a paradigm for patterning, consists of an array specialized fungiform papillae structures that harbor taste cells. formation is preceded by pronounced spatial changes in gene expression, which cell genes such as Shh, initially diffused lingual epithelial progenitors, become restricted to cells when their specification progresses. However, the requirement restriction expression patterning...