In chronic kidney disease (CKD), decreased erythropoietin production, low serum active vitamin D levels, and high renin-angiotensin-aldosterone activities had been regarded as major causes of renal anemia. At present, no clinical data are available to elucidate the association between anemia fibroblast growth factor 23 (FGF23) levels in CKD. This study aimed access whether FGF23 is involved pathogenesis cross-sectional observational included 53 stable outpatients with CKD stages 3 4. Our...

Abstract Background Diabetic nephropathy has attracted many researchers' attention. Because of the emerging evidence about effects advanced glycation end products (AGEs) and receptor AGE (RAGE) on progression diabetic nephropathy, a number different therapies to inhibit or RAGE are under investigation. The purpose present study was examine whether peroxisome proliferator‐activated δ (PPARδ) agonist (L‐165041) epigallocatechin gallate (EGCG) alters AGE‐induced pro‐inflammatory gene expression...

Abstract Background Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect peroxisome proliferator-activated receptor-delta (PPARδ) agonists was shown previous studies. PPARδ also stimulate glucagon-like peptide-1 (GLP-1) secretion from human intestinal cells. Methods In this study, the individual synergic anti-inflammatory effects GLP-1 (exendin-4) (L-165,041) AGE-treated...

Serotonin via serotonin 2B receptors (SR2BR) regulates cardiac embryonic development and adult heart functions. However, the role of SR2BR in failing due to pressure overload is not well understood.Wistar rats aortic banding neonatal cardiomyocyte with mechanical stretch were used as cardiomyopathy models.After two weeks surgery, serum serotonin, mRNA protein expression increased significantly. The selective antagonist, SB215505 (SB), significantly reduced increase weight, decreased wall...

The anti-oxidant effects of epigallocatechin gallate (EGCG) and alpha lipoic acid (ALA) have been demonstrated in previous studies. kidney protection EGCG ALA patients with injury are still under investigation. purpose this study is to investigate the anti-inflammatory on high glucose-induced human cell damage. inhibited glucose(HG)-induced TNF-α IL-6 production embryonic (HEK) cells. Both decreased HG-induced receptor advanced glycation end products (RAGE) mRNA protein expressions HEK also...

Abstract Despite reported evidence on the relationship between higher serum aluminum levels and poor outcomes in patients chronic hemodialysis (CHD), acceptable cutoff value of for mortality remains unclear. A retrospective observational cohort study with 636 Taiwanese CHD was conducted to investigate impact mortality. The predictors were bivariate level (<6 ≥6 ng/mL) Outcomes all-cause cardiovascular (CV) During mean follow-up 5.3 ± 2.9 years, 253 173 CV deaths occurred. Crude analysis...

Hypokalemia is one of the most common clinical electrolyte imbalance problems, and thyrotoxic periodic paralysis (TPP) a leading cause presentation to emergency department. Low renal potassium secretion rates, normal acid-base balance in blood, hyperthyroidism are hallmarks suspected TPP.Here we report case 36-year-old man who presented department with sudden onset acute muscle weakness at 5 h prior admission. Biochemistry tests revealed hypokalemia wasting. TPP was initially not favored due...

Efficacy and safety of a low-molecular-weight heparin (LMWH) were studied in 33 stable maintenance hemodialysis patients who had bleeding tendency on unfractionated heparin. The optimal dose LMWH for each patient was titrated before the study; mean total dosage 1,152 ± 574 IU. No major or clot formation noted 2,470 sessions during 6 months administration. value plasma anti-factor Xa (anti-Xa) activity increased from 0.05 0.03 IU/ml dialysis to 0.34 0.28 after 2 h returned 0.15 0.09 4...

Abstract Iliopsoas abscess is a rare complication in hemodialysis patients that mainly due to adjacent catheterization, local acupuncture, discitis, and bacteremia. Herein, we report 47‐year‐old woman undergoing regular via catheter the internal jugular vein who presented with low back pain dyspnea. A heart murmur suggested presence of catheter‐related endocarditis, this was confirmed by an echocardiogram blood culture methicillin‐resistant S taphylococcus aureus . computed tomography...

Background: The ankle-brachial index (ABI) is associated with peripheral vascular atherosclerosis, adverse cardiovascular outcomes, and all-cause mortality. However, there were limited data available on studying the effect of interleg ABI difference. Methods: We investigated association difference overall mortality in chronic hemodialysis a retrospective observational cohort 369 Taiwanese patients undergoing hemodialysis. Results: An ≥0.15 had significant predictive power for crude analysis....

Thyrotoxic periodic paralysis (TPP) is characterized by the presence of muscle paralysis, hypokalemia, and hyperthyroidism. We report case a young man with lower extremities, severe concurrent TPP was suspected; therefore, treatment consisting judicious potassium (K+) repletion β-blocker administration initiated. However, urinary K+ excretion rate, as well refractoriness to treatment, inconsistent TPP. Chronic alcoholism considered an alternative cause serum restored through vigorous...

BACKGROUND:Thyrotoxic periodic paralysis (TPP) is commonly observed in patients with acute and hyperthyroidism. However, there a possibility of secondary causes hypokalemia such setting. CASE REPORT:Herein, we present the case 38-year-old woman untreated hypertension She presented muscle weakness, nausea, vomiting, diarrhea since one week. The initial diagnosis was TPP. biochemistry tests showed metabolic alkalosis renal potassium wasting. Moreover, suppressed plasma renin level high...

Objectives Maintenance of vascular access (VA) patency after percutaneous transluminal angioplasty (PTA) is important and remains a challenge despite VA monitoring surveillance. The aim this study was to examine factors affecting the post-PTA arteriovenous (AVA) in patients who have been on close surveillance for flow. Design Retrospective cohort study. Setting A single medical centre Taiwan. Participants Records received chronic haemodialysis between 1 January 2017 31 December 2018 were...

BACKGROUND:Rapid shifting between extracellular and intracellular phosphorus can occur during dialysis sessions, which cause aberrant signaling in long-term hemodialysis (LTHD) patients. However, the effect of these intra-dialysis fluctuations on clinical outcomes has not been examined. Therefore, we investigated relationship intradialysis serum reduction ratio (IDSPRR) mortality LTHD MATERIAL AND METHODS:This was a retrospective, observational cohort study to assess predictive power IDSPRR...

Background We explored the long-term safety and efficacy of ferric citrate in hemodialysis patients Taiwan, further evaluated iron repletion effect change parameters by different baseline groups. Methods This was a 12-month, Phase IV, multicenter, open-label study. The initial dose administered patients’ clinical condition adjusted to maintain serum phosphorus at 3.5–5.5 mg/dL. primary endpoint assess profiles citrate. secondary endpoints were evaluate time-course changes number subjects who...

The cardiothoracic ratio (CTR) and serum aluminum levels are both associated with mortality in hemodialysis patients. However, limited data regarding the association between CTR have been published to date. Therefore, we aimed elucidate this patients on chronic (CHD). We investigated level CHD a retrospective cross-sectional study of 547 Taiwanese CHD. mean age was 62.5±13.2 years, time 7.1±5.2 years. Among patients, 36.9% were diabetic 47.9% male. After natural logarithmic transformation...

Abstract Patients with uremia are often immunocompromised and patients undergoing maintenance dialysis vulnerable to uncommon infections. We report a 40‐year‐old man who was hemodialysis initially diagnosed monomicrobal necrotizing fasciitis of the lower limbs, based on blood pus cultures that yielded E scherichia coli . His condition improved after surgical debridement antibiotic therapy. However, he eventually died intracranial hemorrhage related septic emboli. Concurrent infective...

As a low-molecular-weight heparin, tinzaparin has effectively been used as an anticoagulant during hemodialysis sessions. However, the impact of different heparin types on dyslipidemia is still controversial. In our study, 434 chronic patients were evaluated. The mean age was 65 ± 13. Forty-eight (11%) and 386 (89%) in unfractionated (UFH) groups, respectively. Triglyceride had significant difference between two groups (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...

The cardiothoracic ratio (CTR) and peripheral arterial occlusive disease (PAOD) are related to mortality in hemodialysis patients. However, data on the association between PAOD CTR limited. In this study, we aim elucidate relationship patients chronic hemodialysis. Using a retrospective cross-sectional study of 622 Taiwanese patients, investigated CTR. was significantly associated with crude analysis. odds (OR) for >0.5 1.77 [95% confidence interval (CI), 1.32-2.37], >0.6 2.18 CI,...