Tetracycline-based matrix metalloproteinase- (MMP-) inhibitors are currently approved for two inflammatory diseases, periodontitis and rosacea. The current study addresses the therapeutic potential of a novel pleiotropic MMP-inhibitor not based on an antibiotic. To induce experimental periodontitis, endotoxin (LPS) was repeatedly injected into gingiva rats one side maxilla; contralateral (control) received saline injections. Two groups were treated by daily oral intubation with chemically...

To assess the effect of chitosan, at concentrations 2.5% and 5.0%, on wettability eroded dentin, followed by analysis surface morphology SEM.104 bovine dentin slabs were ground, polished then immersed in 20mL citric acid (pH=3.2) under continuous stirring for 2h. Specimens randomly divided according to substrate: sound eroded, then, subdivided into 4 groups (n=10): without rewetting (control), 1% acetic acid, chitosan 5.0% chitosan. Then, a drop adhesive system Single Bond 2 (3M) was...

Curcumin has therapeutic potential in preventing several types of cancer, including colon, liver, prostate, and breast. The goal this study was to evaluate the chemopreventive activity systemically administered curcumin on oral carcinogenesis induced by 4-nitroquinolone-1-oxide (4-NQO). A total 50 male albino rats, Rattus norvegicus, (Holtzman), were divided into five groups (n = 10 per group). Four these exposed ppm 4-NQO their drinking water ad libitum for 8 or 12 weeks, two treated with...

Periodontitis is a chronic inflammatory condition characterized by destruction of non-mineralized and mineralized connective tissues. It initiated maintained dysbiosis the bacterial biofilm adjacent to teeth with increased prevalence Gram-negative microorganisms. Nucleotide-binding oligomerization domain containing 1 (NOD1) member Nod-like receptors (NLRs) family proteins that participate in activation innate immune system, response invading bacteria or antigens present cytoplasm. The...

The purpose of this study was to assess the bond strength a restorative material bleached dentin, pretreated with Er:YAG laser.Laser irradiation for dental surface treatment may increase tooth surface. There are no reports using laser on dentin 35% hydrogen peroxide.Forty maxillary canines were sectioned, resulting in 80 fragments (5×5 mm) intracoronary that divided into eight groups (n=10) according bleaching (present or not), conditioning (with without laser) and post-bleaching time...

The use of polymer additives that stabilize fluidic amorphous calcium phosphate is key to obtaining intrafibrillar mineralization collagen in vitro. On the other hand, this biomimetic approach inhibits nucleation mineral crystals unconfined extrafibrillar spaces, is, mineralization. content a significant feature replicate from hard connective tissues such as bone and dentin it contributes final microarchitecture mechanical stiffness biomineral composite. Herein, we report straightforward...

Abstract The cross‐infections may occur during handling of dental elements, affecting the health practitioners and researchers. This study aimed to analyze influence storage medium temperature on bacterial contingent human teeth used for research purposes. Thirty were donated Human Teeth Biobank immediately after extraction. cleaned with tap water neutral soap. randomly distributed according solution (deionized water): at 4 °C (refrigerator) or −10 (freezer) stored individually in sterile...

Abstract To evaluate the influence of pre-treatment with 2.5% nanoparticulate chitosan (2.5% NanoChi) solution on eroded dentin before restorative dental treatment. The sample consisted 22 patients (age between 33 and 52 years) shallow or medium erosion lesions located in two homologous teeth. teeth were randomly assigned according to treatment: NanoChi without (control). applied immediately after acid etching. restored Single Bond Universal (3 M) Charisma resin (Kulzer). Analyzes done using...

This study aimed to investigate dentin wettability and surface morphology after selective removal of carious lesion by erbium-doped yttrium aluminum garnet (Er:YAG) laser, followed biomodification with carbodiimide (EDC) chitosan (CHI). Seventy-eight bovine specimens were submitted caries induction. Specimens distributed according methods (n = 39): bur at low-speed (40,000 rpm) or Er:YAG laser (noncontact mode, 250 mJ/pulse 4Hz). All etched 35% phosphoric acid, subdivided 13): Control (no...

Introduction: This study aimed to evaluate the child's salivary cortisol levels, clinical performance and marginal adaptation of restorations after selective removal necrotic dentin in primary teeth using Er: YAG laser irradiation. Methods: A double-blind was performed children at 7-10 years. Children who had least 2 with carious lesions involving occlusal proximal surfaces molars counterparts were selected. Removal by methods: irradiation bur-preparation. Cortisol levels (n =24) evaluated...

This study evaluated the effects of Er:YAG laser irradiation applied at varying pulse repetition rate on surface roughness eroded enamel.Bovine enamel slabs (n = 10) were embedded in polyester resin, ground, and polished. To erosive challenges, specimens immersed two times per day 20mL concentrated orange juice (pH 3.84) under agitation, during a two-day period. Specimens randomly assigned to with (focused mode, energy 60 mJ density 3.79 J/cm(2) ) operating 1, 2, 3, or 4 Hz. The control...

Introduction: This study evaluated the impact of CO2 laser treatment and acidulated phosphate fluoride (APF) on enamel demineralization biofilm formation, using in vitro situ designs. Methods: Demineralized slabs were distributed among 8 groups: placebo, placebo + continuous laser, repeated ultrapulsed 1.23% APF, APF laser. In study, 15 from each group subjected to a pH-cycling regimen for 14 days. cross over design, 11 volunteers wore palatal appliances with demineralized 2 periods days...

To assess the effect of Er:YAG and diode lasers on shear bond strength (SBS) adhesive systems to bovine dentin submitted bleaching with a high concentration agent. One hundred twenty fragments were used. Fragments distributed into 12 groups (n = 10) considering (present or not), surface post-treatment (untreated, laser laser) system (total-etching self-etching). Specimens received two applications 38% hydrogen peroxide. (2940 nm, 200 mJ, 4 Hz) (980 1.5 W) applied for 15 s bleached surface....

Univ Sao Paulo State UNESP, Araraquara Sch Dent, Dept Diag &Surg, BR-14801903 Araraquara, SP, Brazil