A5076736517- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- Family Support in Illness
- Histone Deacetylase Inhibitors Research
- Colorectal and Anal Carcinomas
- Photoacoustic and Ultrasonic Imaging
- Histiocytic Disorders and Treatments
- DNA and Nucleic Acid Chemistry
- Molecular Biology Techniques and Applications
- Tumors and Oncological Cases
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Vascular Tumors and Angiosarcomas
- Glioma Diagnosis and Treatment
- DNA Repair Mechanisms
- Cancer and Skin Lesions
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Teratomas and Epidermoid Cysts
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University Hospital Leipzig
2018-2023
Martini-Klinik
2022
Deutsche Diabetes Stiftung
2022
German Cancer Aid
2022
Society of Paediatric Oncology and Haematology
2022
Siemens (Germany)
2016
Roche (Switzerland)
2016
Janssen (Belgium)
2016
Leipzig University
2016
Universitätsmedizin Greifswald
2012-2015
Approximately 20% of children with acute lymphoblastic leukemia (ALL) suffer a relapse, and their prognosis is unfavorable. Between 1987 1990, the multicenter trial Acute Lymphoblastic Leukemia-Relapse Study Berlin-Frankfurt-Münster Group (ALL-REZ BFM) 87 was conducted to establish uniform treatment for these in Germany Austria.Of 207 registered patients, 183 patients were stratified into three groups according protocol: A, early bone marrow (BM) relapse (n = 56); B, late BM 101); C,...
Overexpression of vascular endothelial growth factor (VEGF) is associated with increased angiogenesis, and invasion in solid tumors, hematologic malignancies. The expression isoforms VEGF, which mediate different effects, can be discriminated by splice-variant-specific quantitative reverse transcription-PCR (RT-PCR), but current methods have only modest sensitivity precision suffer from heteroduplex formation.We used a real-time RT-PCR assay on the LightCycler system. Applicability for...
Introduction Colorectal carcinoma (CRC) is the second most common adult cancer in Germany, however, it extremely rare children and adolescents. In these patients, previous literature describes aggressive behavior diagnosis at advanced stage. Method Thirty‐one patients with CRC age ≤ 18 years treated between 1990 2012 have been identified through structures registries of German Society for Pediatric Oncology Hematology. Results The range was 9–18 (median 13.5 years); median follow‐up time...
Identification of intracerebral hemorrhage (ICH) and the underlying cause is a common clinical problem. Rare causes ICH can be particularly difficult to diagnose. We describe man on oral anticoagulation with multiple progressive ICHs, who initially showed no signs malignant disease. After normalisation all coagulation tests, ICHs continued spread. Autopsy examination revealed an angiosarcoma. Multiple caused by angiosarcoma that mainly affects brain have not yet been described. In presence...
Pediatric brain tumors of the posterior fossa often present with occlusive hydrocephalus. Endoscopic third ventriculostomy (ETV) or ventriculoperitoneal shunting (VPS) has been established for definite hydrocephalus treatment. The aim study was to analyze impact and safety perioperative temporary external ventricular CSF drainage (EVD) placement on postoperative outcome compared a no-EVD strategy.In prospective database, 36 tumor patients 2-18 years were included follow-up 1 year....
DNAzymes represent a new generation of catalytic nucleic acids for specific RNA targeting in order to inhibit protein translation from the specifically cleaved mRNA. The 10–23 DNAzyme was found hydrolyze sequence-specific manner both vitro and vivo. Although single-stranded may most effective acid drug date, they are nevertheless sensitive nuclease degradation require modifications vivo application. However, previously used stabilization by site-specific phosphorothioate (PT) reduces...
Zusammenfassung Hintergrund Krebserkrankungen bei Kindern sind mit einem erhöhten Risiko für psychosoziale Belastungen assoziiert. Zur quantitativen und qualitativen Bedarfseinschätzung nach psychosozialer Nachsorge liegen bisher keine Instrumente vor. Mit dem NPO-11 wurde nun ein ökonomisches Screening entwickelt. Patient:innen Methoden 11 dichotome Items erfassen die Bereiche Progredienzangst, Traurigkeit, Antrieblosigkeit, Selbstwertprobleme, Schul- Ausbildungsprobleme, somatische...
The cell cycle regulatory circuit resulting in phosphorylation of the retinoblastoma protein (pRB) is frequently altered human cancers. Several mechanisms disruption are known that pathway. In childhood acute lymphoblastic leukemia (ALL), main disrupting mechanism homozygous deletion CDKN2 (cyclin dependent kinase inhibitor 2) genes: p16CDKN2a p15CDKN2b and p19ARF Another pRB pathway disturbance a previously described point mutation exon 2 CDK4, phosphorylating enzyme, which abrogates...
Gastric teratomas are very rare embryonal neoplasms, accounting for 2.6% of all perinatal diagnosed germ cell tumours. About 85% well-differentiated mature lesions and about 15% immature tumours with the potential malignant transformation. The recommended therapy gastric is surgical excision. We present case a 6-month-old boy an incidentally detected epigastric mass. histological examination revealed teratoma. diagnostic imaging, postoperative follow-up discussed.
A 4-year-old boy presented with a 3-year history of nonhealing scalp lesions; physical examination revealed multiple disseminated erythematous papules, petechial hemorrhages, and yellowish crusts. What is your diagnosis?
Cure rates of childhood ALL improved distinctly in the past decades. Nevertheless, ca. 20% patients relapse, and their prognosis is clearly worse. We describe design long term results multicenter trial ALL-REZ BFM 87 for children with first relapse ALL. Patients (n=207) were stratified into three risk-groups (RG, A: early bone marrow (BM) B: late BM C: isolated extramedullary relapse), alternatively, a poor (very or any T-ALL) could be enrolled to an experimental pilot regimen (P88)....
Hintergrund. Krebserkrankungen bei Kindern sind mit einem erhöhten Risiko für psychosoziale Belastungen assoziiert. Zur quantitativen und qualitativen Bedarfseinschätzung nach psychosozialer Nachsorge liegen bisher keine Instrumente vor. Mit dem NPO-11 wurde nun ein ökonomisches Screening entwickelt. Patienten Methoden. Elf dichotome Items erfassen die Bereiche Progredienzangst, Traurigkeit, Antrieblosigkeit, Selbstwertprobleme, Schul- Ausbildungsprobleme, somatische Beschwerden, emotionaler...