A5075443468- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Multisensory perception and integration
- Neuroscience and Music Perception
- Anomaly Detection Techniques and Applications
- Marine animal studies overview
- Receptor Mechanisms and Signaling
- Opinion Dynamics and Social Influence
- Acute Myeloid Leukemia Research
- Neural and Behavioral Psychology Studies
- Chronic Myeloid Leukemia Treatments
- Bat Biology and Ecology Studies
- Advanced Text Analysis Techniques
- Music Technology and Sound Studies
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Cutaneous Melanoma Detection and Management
- Animal Vocal Communication and Behavior
- Underwater Acoustics Research
- Hearing Loss and Rehabilitation
- Structural Health Monitoring Techniques
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
Johns Hopkins University
2020-2025
Discovery Institute
2023-2025
Universitätsklinikum Erlangen
2015-2019
Institute of Genetics
2019
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019
Centre National de la Recherche Scientifique
2016-2017
Laboratoire des Systèmes Perceptifs
2016-2017
Université Paris Sciences et Lettres
2017
École Normale Supérieure
2017
Alzheimer's disease (AD) is a form of dementia in which memory and cognitive decline thought to arise from underlying neurodegeneration. These impairments, however, are transient when they first appear can fluctuate across progression. Here, we investigate the neural mechanisms fluctuations performance amnestic mice. We trained APP/PS1+ mice on an auditory go/no-go task that dissociated learning contingencies (knowledge) its more variable expression under reinforcement (performance)....
In a family expressing euthyroid hyperthyroxinemia, an increased association of plasma thyroxine (T4) with transthyretin (TTR) is transmitted by autosomal dominant inheritance and secondary to mutant TTR molecule affinity for T4. Eight individuals spanning three generations exhibited the abnormality. Although five eight had elevated total T4 concentrations, all affected were clinically normal free levels. Purified from propositus 125I-T4 times that control TTR. Exons 2, 3, 4 (representing...
Natural sounds such as wind or rain, are characterized by the statistical occurrence of their constituents. Despite complexity, listeners readily detect changes in these contexts. We here address neural basis decision-making using a combination psychophysics, EEG and modelling. In texture-based, change-detection paradigm, human performance reaction times improved with longer pre-change exposure, consistent estimation baseline statistics. Change-locked decision-related responses were found...
Introduction Colorectal carcinoma (CRC) is the second most common adult cancer in Germany, however, it extremely rare children and adolescents. In these patients, previous literature describes aggressive behavior diagnosis at advanced stage. Method Thirty‐one patients with CRC age ≤ 18 years treated between 1990 2012 have been identified through structures registries of German Society for Pediatric Oncology Hematology. Results The range was 9–18 (median 13.5 years); median follow‐up time...
Abstract Quantification of tumour‐specific molecular markers at the RNA and DNA level for treatment response monitoring is crucial risk‐adapted stratification guidance individualized therapy in leukaemia other malignancies. Most pediatric leukaemias solid tumours mesenchymal origin are characterized by a relatively low mutation burden single nucleotide presence recurrent chromosomal translocations. The genomic fusion sites resulting from translocations stable tumour markers; however,...
Background Malignant melanoma (MM) is a common malignancy in adults while it rare children. Thus, information on clinical behavior of pediatric MM incomplete. Patients The German Pediatric Rare Tumor Registry (STEP) presents prospective analysis 60 childhood cases diagnosed between June 2006 and December 2014. Method Patients' ages ranged 0 17 years at initial diagnosis (median age 9.6 years). Information patient's tumor characteristics was obtained by standardized documentation. Three-year...
Everyday life's perceptual decision-making is informed by experience. In particular, temporal expectation can ease the detection of relevant events in noisy sensory streams. Here, we investigated if humans extract hidden cues from occurrences probabilistic targets and utilize them to inform target a complex acoustic stream. To understand what neural mechanisms implement influence on decision-making, used pupillometry as proxy for underlying neuromodulatory activity. We found that...
Rapid categorization of vocalizations enables adaptive behavior across species. While categorical perception is thought to arise in the neocortex, humans and other animals could benefit from functional organization ethologically-relevant sounds at earlier stages auditory hierarchy. Here, we developed two-photon calcium imaging awake echolocating bat (
Abstract Background Alzheimer’s disease is a progressive form of dementia where cognitive capacities deteriorate due to neurodegeneration. Interestingly, patients exhibit fluctuations during all stages the disease. Though it thought that contextual factors are critical for unlocking these hidden memories, understanding neural basis has been hampered lack behavioral approaches dissociate memories from contextual‐performance. Our previous work demonstrated interleaving reinforced with...
Abstract Mixed-lineage leukemia (MLL) fusions are transcriptional activators that induce leukemia, with a dismal prognosis mandates further elucidation of their transformation mechanism. In this study, knockdown the direct MLL-ENL target gene polypyrimidine tract binding protein-1 (PTBP1) was rate limiting for cell proliferation and caused metabolic phenotype associated reduced glucose consumption lactate production. This effect accompanied by reduction splice isoform-2 pyruvate kinase M...
Abstract Cholinergic basal forebrain (CBF) signaling exhibits multiple timescales of activity with classic, slow signals related to brain and behavioral states faster, phasic reflecting events, including movement reinforcement. Recent evidence suggests that the CBF may also exhibit fast, sensory-evoked responses. It remains unknown, however, whether such sensory target cortex how they relate local functional topography. Moreover, extent which fast interact has been largely unexplored. Here,...
Abstract Background Memories must be accessible for them to useful. Alzheimer’s disease (AD) is a progressive form of dementia in which cognitive capacities slowly deteriorate due underlying neurodegeneration. Interestingly, anecdotal observations have demonstrated that patients can exhibit fluctuations during all stages the disease. In particular, it thought contextual factors are critical unlocking these hidden memories. To date, however, exploration neural basis has been hampered lack...
In the era of tyrosine-kinase inhibitor treatment stop trials in patients with CML, quantification BCR-ABL1 fusion is an essential tool to guide decisions. For detection transcript-negative CML cells, DNA-based assays are alternative approach. However, repeat-rich DNA sequences at breakpoint limit design conventional PCR for minimal residual disease (MRD) monitoring.
Background: MLL fusions are aberrant transcription factors that induce highly aggressive and hard‐to‐treat leukemia with dismal prognosis. A better understanding of specific properties may reveal potential therapeutic intervention points. Aims: Known direct downstream targets MLL‐ENL were scored for their importance leukemic cell survival genes a positive readout further investigated targeting potential. Methods: shRNA screen interrogating known target identified the splice‐modulator PTBP1...
Abstract Background Alzheimer’s disease (AD) is a form of dementia that characterized by the progressive loss cognitive capacity, including executive functions and memory. There growing evidence suggesting hearing are tightly linked, with recent studies showing independently associated accelerated decline. However, neural mechanisms linking to AD‐related pathologies subsequent decline remain unknown. Method We will test hypothesis amyloid pathology impacts feedforward sensory processing in...
Abstract Estimating temporal regularities in incoming sensory inputs supports optimal decisions noisy environments. In particular, inferred structure can ease the detection of likely target events. Here we postulated that timely urgency signals adapt subjects’ decision-making to ongoing task structure, possibly through neuromodulatory tone. To test this hypothesis, used an auditory change which targets followed a block-based contingency, unbeknownst participants. False alarm occurrences were...