A5014777818- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
Johns Hopkins University
2022-2023
Yale-NUS College
2019-2020
The brains of Alzheimer's disease patients show a decrease in brain mass and preponderance extracellular Amyloid-β plaques. These plaques are formed by aggregation polypeptides that derived from the Amyloid Precursor Protein (APP). thought to play either direct or an indirect role progression, however exact plaque formation aetiology (AD) is subject debate as biological effects soluble aggregated peptides difficult separate vivo. To investigate consequences oligomers living tissues, we...
Abstract The brains of Alzheimer’s Disease patients show a decrease in brain mass and preponderance extracellular Amyloid-β plaques. These plaques are formed by aggregation polypeptides that derived from Amyloid Precursor Protein (APP). thought to play either direct or an indirect role disease progression, however the exact plaque formation ethology is subject debate, not least because biological effects soluble aggregated peptides difficult separate vivo . To investigate consequences...
Abstract Cholinergic basal forebrain (CBF) signaling exhibits multiple timescales of activity with classic, slow signals related to brain and behavioral states faster, phasic reflecting events, including movement reinforcement. Recent evidence suggests that the CBF may also exhibit fast, sensory-evoked responses. It remains unknown, however, whether such sensory target cortex how they relate local functional topography. Moreover, extent which fast interact has been largely unexplored. Here,...