A5054373427- Zebrafish Biomedical Research Applications
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Neuroendocrine regulation and behavior
- Ichthyology and Marine Biology
- Identification and Quantification in Food
- Alzheimer's disease research and treatments
- Fish Biology and Ecology Studies
- Cephalopods and Marine Biology
- Evolutionary Psychology and Human Behavior
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Regulation of Appetite and Obesity
- Microbial Natural Products and Biosynthesis
- Chemistry and Stereochemistry Studies
- Agricultural and Biological Research
- Neurotransmitter Receptor Influence on Behavior
- Medicinal Plant Research
- Stress Responses and Cortisol
- Mercury impact and mitigation studies
- Physiological and biochemical adaptations
- Memory and Neural Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Neuroinflammation and Neurodegeneration Mechanisms
National University of Singapore
2021-2024
Yale-NUS College
2019-2024
Universiti of Malaysia Sabah
2023
Institute of Molecular and Cell Biology
2014-2020
Institute of Molecular and Cell Biology
2020
Duke-NUS Medical School
2010
Agency for Science, Technology and Research
2010
Zebrafish are highly social teleost fish and an excellent model to study behavior. The neuropeptide Oxytocin is associated different behaviors as well disorders resulting in impairment like autism spectrum disorder. However, how receptor signaling affects the development expression kinetics of behavior not known. In this we investigated role two oxytocin receptors, Oxtr Oxtrl, maintenance preference shoaling 2- 8-week-old zebrafish. Using CRISPR/Cas9 mediated oxtr oxtrl knock-out fish, found...
The brains of Alzheimer's disease patients show a decrease in brain mass and preponderance extracellular Amyloid-β plaques. These plaques are formed by aggregation polypeptides that derived from the Amyloid Precursor Protein (APP). thought to play either direct or an indirect role progression, however exact plaque formation aetiology (AD) is subject debate as biological effects soluble aggregated peptides difficult separate vivo. To investigate consequences oligomers living tissues, we...
Neural activity in the vertebrate habenula is affected by ambient illumination. The nucleus that links photoreceptor with not well characterized. Here, we describe location, inputs and potential function of this larval zebrafish. High-speed calcium imaging shows light ON OFF both evoke a rapid response dorsal left neuropil habenula, indicating preferential targeting afferents conveying information about Injection lipophilic dye into led to bilateral labeling anterior thalamus responds OFF,...
Neural circuits are non-linear dynamical systems that transform information based on the pattern of input, current state and functional connectivity. To understand how a given stimulus is processed, one would ideally record neural activity across entire brain behaving animal, at cellular or even subcellular resolution, in addition to characterizing anatomical Given their transparency relatively small size, larval zebrafish provide powerful system for brain-wide monitoring activity....
Alcohol use disorders are complex, multifactorial phenomena with a large footprint within the global burden of diseases. Here, we report development an accessible, two-choice self-administration zebrafish assay (SAZA) to study neurobiology addiction. Using this assay, first demonstrated that, although avoid higher concentrations alcohol, they attracted low concentrations. Pre-exposure alcohol did not change relative preference, but acute exposure deterrent approved for human decreased...
Overfishing has significantly decreased global shark populations, with some species experiencing reductions of approximately 70% over the last 50 years. Singapore is a major fin transhipment hub that helps to satisfy demand for fins, which are considered status symbols and reputed have medicinal value in Asian culture. Despite recognised urgent need better protect success such efforts been limited by difficulties associated visually identifying from fins originated. In this study, we...
Abstract Interaction with social partners during or after a stressful episode aids recovery in humans and other mammals. We asked if comparable phenomenon exists zebrafish (Danio rerio) that live shoals the wild. In first experiment, we observed most quantifiable parameters of swimming behavior were similar when zerbafish swam alone companions. However, exposure to an alarm substance ( Schreckstoff ), individuals recovering continued display behaviors associated fear removal stimulus, while...
Alzheimer's Disease (AD) has long been associated with accumulation of extracellular amyloid plaques (Aβ) originating from the Amyloid Precursor Protein. Plaques have, however, discovered in healthy individuals and not all AD brains show plaques, suggesting that Aβ aggregates may play a smaller role than anticipated. One limitation to studying peptide
Abstract Background Neural activity in the vertebrate habenula is affected by changes ambient illumination. The nucleus that links photoreceptors with not well characterized. Here, we describe location, inputs and potential function of this larval zebrafish. Results High-speed calcium imaging shows onset offset light evokes a rapid response dorsal left neuropil habenula, indicating preferential targeting afferents mediating to change irradiance. Injection lipophilic dye into led bilateral...
Sixty-four soil samples and fluid from seven Nephenthes pitchers were obtained the Trus Madi Mountain, Sabah
Abstract Alcohol use disorders (AUDs) are complex phenomena governed by genetics, neurophysiology, environment, and societal structures. New methods to understand the underlying neurogenetics valuable for designing personalised interventional strategies. Here, we used a novel, two-choice self-administration zebrafish assay (SAZA) isolate function of nicotinic acetylcholine receptor (nAChR) subunit alpha3 ( chrna3 ) in alcohol response. Juvenile exhibited biphasic response when...
Abstract The brains of Alzheimer’s Disease patients show a decrease in brain mass and preponderance extracellular Amyloid-β plaques. These plaques are formed by aggregation polypeptides that derived from Amyloid Precursor Protein (APP). thought to play either direct or an indirect role disease progression, however the exact plaque formation ethology is subject debate, not least because biological effects soluble aggregated peptides difficult separate vivo . To investigate consequences...
Maliau Basin is one of the world's hot spot biodiversity.
Abstract Zebrafish are highly social teleost fish and an excellent model to study behavior. The neuropeptide Oxytocin is associated different behaviors as well disorders resulting in impairment like autism spectrum disorder. However, how receptor signaling affects the development expression kinetics of behavior not known. In this we investigated role two oxytocin receptors, Oxtr Oxtrl, maintenance preference shoaling 2- 8-week-old zebrafish. Using CRISPR/Cas9 mediated oxtr oxtrl knock-out...
Abstract Alcohol use disorders are complex, multifactorial phenomena with a large footprint within the global burden of diseases. Here, we report development an accessible, two-choice self-administration zebrafish assay (SAZA) to study neurobiology addiction. Using this assay, first demonstrated that, while avoid higher concentrations alcohol, they attracted low concentrations. Pre-exposure alcohol did not change relative preference, but acute exposure deterrent approved for human decreased...