A5059500795- Zebrafish Biomedical Research Applications
- Neuroendocrine regulation and behavior
- Animal Behavior and Reproduction
- Receptor Mechanisms and Signaling
- Cephalopods and Marine Biology
- Neurobiology and Insect Physiology Research
- Evolutionary Psychology and Human Behavior
- Physiological and biochemical adaptations
- Hippo pathway signaling and YAP/TAZ
- Research Data Management Practices
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Neuropeptides and Animal Physiology
- Multisensory perception and integration
- Neurogenesis and neuroplasticity mechanisms
- Hereditary Neurological Disorders
- scientometrics and bibliometrics research
- Color perception and design
- Single-cell and spatial transcriptomics
- Scientific Computing and Data Management
- Neurogenetic and Muscular Disorders Research
Friedrich Miescher Institute
2023-2024
Max Planck Institute for Brain Research
2020-2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016
Open science (OS) is of paramount importance for the improvement worldwide and across research fields. Recent years have witnessed a transition toward open transparent scientific practices, but there still long way to go. Early career researchers (ECRs) are crucial relevance in process steering standardization OS as they will become future decision makers institutional change that necessarily accompanies this transition. Thus, it imperative gain insight into where ECRs stand on practices....
Zebrafish are highly social teleost fish and an excellent model to study behavior. The neuropeptide Oxytocin is associated different behaviors as well disorders resulting in impairment like autism spectrum disorder. However, how receptor signaling affects the development expression kinetics of behavior not known. In this we investigated role two oxytocin receptors, Oxtr Oxtrl, maintenance preference shoaling 2- 8-week-old zebrafish. Using CRISPR/Cas9 mediated oxtr oxtrl knock-out fish, found...
Objective Mutations in the spastic paraplegia gene 11 (SPG11), encoding spatacsin, cause most frequent form of autosomal‐recessive complex hereditary (HSP) and juvenile‐onset amyotrophic lateral sclerosis (ALS5). When SPG11 is mutated, patients frequently present with paraparesis, a thin corpus callosum, cognitive impairment. We previously delineated neurodegenerative phenotype neurons these patients. In current study, we recapitulated early developmental phenotypes outlined their cellular...
Behavior is context-dependent and often modulated by an animal's internal state. In particular, different social contexts can alter anxiety levels modulate behavior. The vertebrate-specific neuropeptide parathyroid hormone 2 (pth2) regulated the presence of conspecifics in zebrafish. As its cognate receptor, receptor (pth2r), widely expressed across brain, we tested fish lacking functional Pth2 peptide several anxiety-related behavior paradigms. Here, show that propensity to react sudden...
The function of neuronal networks is determined not only by synaptic connectivity but also neuromodulatory systems that broadcast information via distributed connections and volume transmission. To understand the molecular constraints organize signaling in telencephalon adult zebrafish, we used transcriptomics additional approaches to delineate cell types, determine their phylogenetic conservation, map expression marker genes at high granularity. combinatorial GPCRs cell-type markers...
Abstract Zebrafish are highly social teleost fish and an excellent model to study behavior. The neuropeptide Oxytocin is associated different behaviors as well disorders resulting in impairment like autism spectrum disorder. However, how receptor signaling affects the development expression kinetics of behavior not known. In this we investigated role two oxytocin receptors, Oxtr Oxtrl, maintenance preference shoaling 2- 8-week-old zebrafish. Using CRISPR/Cas9 mediated oxtr oxtrl knock-out...
Summary Animal behavior is strongly context-dependent and behavioral performance often modulated by internal state. In particular, different social contexts can alter anxiety levels modulate behavior. The vertebrate-specific neuropeptide parathyroid hormone 2 ( pth2 ) directly regulated the presence or absence of conspecifics in zebrafish. As its cognate receptor, receptor pth2r ), widely expressed across brain, we tested fish lacking functional Pth2 peptide several anxiety-related...
The function of neuronal networks is determined not only by synaptic connectivity but also neuromodulatory systems that broadcast information via distributed connections and volume transmission. To understand the molecular constraints organize signaling in telencephalon adult zebrafish we used transcriptomics additional approaches to delineate cell types, determine their phylogenetic conservation, map expression marker genes at high granularity. combinatorial GPCRs type markers indicates all...
Abstract The function of neuronal networks is determined not only by synaptic connectivity but also neuromodulatory systems that broadcast information via distributed connections and volume transmission. To understand the molecular constraints organize signaling in telencephalon adult zebrafish we used transcriptomics additional approaches to delineate cell types, determine their phylogenetic conservation, map expression marker genes at high granularity. combinatorial GPCRs type markers...