A5072381939- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Antimicrobial Resistance in Staphylococcus
- Parkinson's Disease and Spinal Disorders
- HIV Research and Treatment
- Virus-based gene therapy research
- Patient Satisfaction in Healthcare
- Streptococcal Infections and Treatments
- Pediatric Urology and Nephrology Studies
- Tuberculosis Research and Epidemiology
- Dupuytren's Contracture and Treatments
- Central Venous Catheters and Hemodialysis
- Dialysis and Renal Disease Management
- Urinary Tract Infections Management
- Microbial infections and disease research
- Pharmaceutical studies and practices
- History of Medical Practice
- HIV/AIDS Research and Interventions
- Medical Research and Treatments
- Quinazolinone synthesis and applications
Johns Hopkins Hospital
2023-2025
Prisma Health
2021-2024
University of South Carolina
2021-2022
Palmetto Health Richland
2021-2022
Abstract Background Necrotizing soft tissue infections (NSTIs) are life-threatening infections. The aim of this study is to evaluate the safety clindamycin plus vancomycin versus linezolid as empiric treatment NSTI. Methods Retrospective, single-center, quasi-experimental patients admitted from June 1, 2018 30, 2019 (pre-intervention) and May 2020 October 15, 2021 (post-intervention). Patients who received surgical management within 24 hours NSTI diagnosis at least one dose or were included....
Abstract Background Pancreatoduodenectomy (PD) or the Whipple is a complex surgical intervention with high complication rates. The purpose of this study to evaluate efficacy standard care (SOC) perioperative antibiotics, cefazolin plus metronidazole, as prophylaxis for site infection (SSI) in patients undergoing PD at Johns Hopkins Hospital (JHH). Methods A retrospective was performed adult JHH between January 1, 2022 and October 31, 2023. following information collected on all patients:...
Abstract Objective: To evaluate temporal trends in the prevalence of gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) southeastern United States. Secondary objective was to examine use novel β-lactams for GNB DTR by both antimicrobial (AU) and a metric adjusted AU microbiological burden (am-AU). Design: Retrospective, multicenter, cohort. Setting: Ten hospitals Methods: including Enterobacterales, Pseudomonas aeruginosa , Acinetobacter spp. from 2015 2020 were tracked at...
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon possible after acceptance. Accepted have been peer-reviewed and copyedited, but are posted before technical formatting author proofing. These not final version record will be replaced with article (formatted per style proofed by authors) at a later time.
Nontuberculous mycobacterial (NTM) infections present a treatment challenge for clinicians and patients. There are limited data about current susceptibility patterns outcomes in U.S. adults. This was 10-year, single-center, retrospective, observational cohort study of adults with positive NTM culture clinical suspicion infection between 1 January 2010 30 June 2020. The primary objective to identify predictors favorable outcomes. Key secondary objectives were characterization epidemiology,...
Abstract Background Several new β-lactam antibiotics were recently developed for treatment of serious infections due to gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR). This multicenter retrospective cohort study examined temporal trends in prevalence GNB DTR and the use β-lactams southeastern United States. Methods The DTR, including Enterobacterales, Pseudomonas aeruginosa, Acinetobacter species was determined 9 hospitals geographically spread within Southeastern...
Abstract Background Cabotegravir/rilpivirine (CAB/RPV) long-acting (LA) injectable was recently approved as a switch therapy for people living with HIV (PLWHIV) who are virologically suppressed on oral combination antiretroviral (cART). Data demonstrates RPV resistance associated mutations (RAMs) correlated CAB/RPV treatment failure. This is the first real-world retrospective, observational study evaluating epidemiology of and CAB RAMs in heavily experienced population PLWHIV. Methods A...
Abstract Background Several methods are used to account for various hospital characteristics when comparing antimicrobial use (AU) between heterogenous hospitals. Recently, a new stewardship metric that adjusts AU by microbiological burden (a-AU) of the bacteria was proposed (Figure 1). It accounts resistant phenotypes observed at given institution, allowing more balanced comparison across This multicenter retrospective cohort study examined β-lactams Gram-negative (GNB) with...
Abstract Background Gaps in evidence concerning the epidemiology of nontuberculous mycobacterial (NTM) organisms and their associated treatment outcomes are evident literature. The aim this study was to describe NTM species distribution susceptibility profile among adult patients at a tertiary referral hospital Southeastern United States. Methods A retrospective cohort with infections from January 1, 2010 June 30, 2020 performed. Included had positive culture for clinical suspicion...