A5082288088- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Innovations in Medical Education
- Bacterial Identification and Susceptibility Testing
- Anatomy and Medical Technology
- Musculoskeletal Disorders and Rehabilitation
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Patient Satisfaction in Healthcare
- Clinical Reasoning and Diagnostic Skills
- Pediatric Urology and Nephrology Studies
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Urinary Tract Infections Management
- Conferences and Exhibitions Management
- Lysosomal Storage Disorders Research
- Patient Safety and Medication Errors
- Poisoning and overdose treatments
- Sepsis Diagnosis and Treatment
- Mobile Learning in Education
- Neurotransmitter Receptor Influence on Behavior
- Cancer Cells and Metastasis
- Congenital heart defects research
- Forensic Toxicology and Drug Analysis
Augusta University Health
2022-2024
WellStar Health System
2024
Emory Healthcare
2019-2022
University of Georgia
2019
Charlie Norwood VA Medical Center
2019
Strong Memorial Hospital
2017
IIT@MIT
2016
Pennsylvania State University
2015
Penn State Milton S. Hershey Medical Center
2014
Long-acting lipoglycopeptides such as dalbavancin may have utility in patients with Gram-positive bloodstream infections (BSI), particularly those barriers to discharge or who require prolonged parenteral antibiotic courses. A retrospective cohort study was performed provide further multicenter real-world evidence on use a sequential therapy for BSI. One hundred fifteen received BSI, defined any positive blood culture diagnosed infective endocarditis, from 13 centers geographically spread...
The purpose of this study was to characterize dynamic changes in medication regimen complexity over time critically ill adults and validate a modified version the complexity-intensive care unit (MRC-ICU) scoring tool.A single-center, retrospective, observational chart review conducted with primary aim assessing time, as measured by both 39-item MRC-ICU tool (the mMRC-ICU) containing just 17 items. Secondary aims included validation mMRC-ICU exploration relationships between ICU length stay...
Abstract Objective: To evaluate temporal trends in the prevalence of gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) southeastern United States. Secondary objective was to examine use novel β-lactams for GNB DTR by both antimicrobial (AU) and a metric adjusted AU microbiological burden (am-AU). Design: Retrospective, multicenter, cohort. Setting: Ten hospitals Methods: including Enterobacterales, Pseudomonas aeruginosa , Acinetobacter spp. from 2015 2020 were tracked at...
Abstract Background Extended-spectrum β-lactamase (ESBL)–producing Enterobacterales are frequent causes of urinary tract infections (UTIs). Severe caused by ESBL often treated with carbapenems, but optimal treatment for less severe such as UTIs is unclear. Methods This retrospective cohort study included patients admitted to 4 hospitals in an academic healthcare system UTI either a noncarbapenem β-lactam (NCBL) or carbapenem at least 48 hours from 1 April 2014 30 2018. Those who received...
Quetiapine is a new antipsychotic drug that has been available in the United States since September 1997. It belongs to chemical class of drugs called dibenzothiazepine derivatives and easily detected with basic screen. The Los Angeles County Department Coroner Toxicology Laboratory encountered quetiapine seven postmortem cases. Tissue distributions were determined each analysis from specimens consisted an n-butylchloride extraction presumptive identification quantitation on gas...
Current undergraduate medical school curricular trends focus on both vertical integration of clinical knowledge into the traditionally basic science‐dedicated curricula and increasing science education in years. This latter type is more difficult less reported than former. Here, we present an outline a course wherein primary learning teaching objective to integrate anatomy with education. The was developed through collaboration by multi‐specialist development team (composed scientists...
Background: Intravenous (IV) antibiotics have historically been considered standard of care for treatment bloodstream infections (BSIs). Recent literature has shown sequential oral (PO) therapy to be noninferior IV certain pathogens and disease states. However, a gap exists in the BSI caused by Enterococcus faecalis. Objective: To compare outcomes definitive PO patients with E faecalis BSI. Methods: Multicenter, retrospective, matched cohort study adult at least one blood culture positive...
Journal Article Fatal Flecainide Intoxication Get access Christopher Rogers, Rogers † Department of Coroner, 1104 North Mission Road, Los Angeles, CA 90033 Author to whom correspondence should be addressed. Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel T. Anderson, Anderson James K. Ribe, Ribe Lakshmanan Sathyavagiswaran Analytical Toxicology, Volume 17, Issue 7, November-December 1993, Pages 434–435, https://doi.org/10.1093/jat/17.7.434 Published: 01...
Background: Short courses of antibiotics (7-10 days) are effective for uncomplicated gram-negative bloodstream infections (GN-BSI). However, prior studies have been limited to small cohorts critically ill patients. Objective: The objective this study was evaluate the safety and efficacy short therapy compared with longer in patients admitted intensive care unit (ICU) GN-BSI. Methods: Propensity-matched, retrospective cohort primary outcome a composite 30-day mortality or 60-day relapse....
Musculoskeletal (MSK) complaints, including back pain, represent a large percentage of physician office visits. Despite the disease burden, current literature suggests physicians are not adequately trained to care for these conditions. Enabling future providers address MSK complaints requires revising medical school curriculum. Here we report novel curriculum developed through application contextual learning theory and targeted needs assessment. The course emphasizes clinical reasoning in...
Medical school curricular trends focus on an increase in basic science education clinical years. This vertical integration is difficult and poorly reported the literature. We have outlined a course wherein primary learning objective to integrate anatomy knowledge with education. has foundation adult theories was developed through collaboration by multi‐specialist development team, composed of both scientists physicians. The developers utilized current published reports regarding areas care...
Glioblastoma microenvironment can be modulated to induce tumor cell death. Here we report a microRNA based approach achieve this end. We employed conducted genetic screen identify miRNAs that confer radiation sensitivity endothelial cells. Targets of key were identified. Efficacy therapeutic delivery was tested in vitro and vivo using patient derived glioblastoma xenograft models. observed silencing the processing enzyme, Dicer, Human Umbilical Vein Endothelial Cells (HUVEC) significantly...
Methicillin-resistant Staphylococcus aureus (MRSA) polymerase chain reaction (PCR) nasal swabs are guideline-recommended de-escalation tools in certain patients with pneumonia. Prior studies have demonstrated reduced anti-MRSA therapy negative results, but the impact on durations of has been poorly elucidated positive PCRs. The objective this review was to evaluate treatment a MRSA PCR absence growth culture. This single-center, retrospective observational study evaluating 52 hospitalized,...
Background: Recent literature demonstrates support for using methicillin-resistant Staphylococcus aureus (MRSA) nasal swab polymerase chain reaction (NaPCR) screening as an antimicrobial stewardship tool aiding early de-escalation of anti-MRSA antimicrobials. However, immunocompromised patients have been underrepresented in previous studies despite increased risk morbidity and mortality from multidrug-resistant organisms (MDRO). Objective: The purpose this study was to determine the negative...
Anatomy integration into clinical year medical education is oft recommended but rarely described. Previously we introduced an innovative approach integrating anatomy medicine. Here present the effects of this vertically‐integrated musculoskeletal (MSK) elective in effort to inform similar curricular innovations. Students participating either a MSK (experimental, n = 25) or humanities course (control, n=19) were evaluated using repeated measures, mixed methods approach. All participants took...
Abstract Background Several new β-lactam antibiotics were recently developed for treatment of serious infections due to gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR). This multicenter retrospective cohort study examined temporal trends in prevalence GNB DTR and the use β-lactams southeastern United States. Methods The DTR, including Enterobacterales, Pseudomonas aeruginosa, Acinetobacter species was determined 9 hospitals geographically spread within Southeastern...