A5100384037- Acute Kidney Injury Research
- Cancer Immunotherapy and Biomarkers
- Pregnancy and Medication Impact
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Renal Transplantation Outcomes and Treatments
- Obstructive Sleep Apnea Research
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Renal and related cancers
- Physical Activity and Health
- Congenital Diaphragmatic Hernia Studies
- Pneumothorax, Barotrauma, Emphysema
- Balance, Gait, and Falls Prevention
- Respiratory Support and Mechanisms
- Renal cell carcinoma treatment
- Pleural and Pulmonary Diseases
- Dementia and Cognitive Impairment Research
- Cholesterol and Lipid Metabolism
- Organ Transplantation Techniques and Outcomes
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Organ Donation and Transplantation
- interferon and immune responses
Second Hospital of Shanxi Medical University
2022-2025
Shanxi Medical University
2022-2025
Rotterdam University of Applied Sciences
2025
Hebei Medical University
2024
Xian Yang Central Hospital
2024
Peking University Shougang Hospital
2021-2024
Hunan Academy of Traditional Chinese Medicine
2022-2024
Yale New Haven Hospital
2023
Erasmus University Rotterdam
2022-2023
Louisiana State University Health Sciences Center New Orleans
2023
Kidney organoids derived from human induced pluripotent stem cells (iPSCs) have proven to be a valuable tool study kidney development and disease. However, the lack of vascularization these often leads insufficient oxygen nutrient supply. Vascularization has previously been achieved by implantation into animal models, however, vasculature arises largely host tissue. Our aim is transition an in vivo model towards vitro that fulfils advantages whilst being fully human-cell derived. chip system...
To investigate the effectiveness and safety of Tai Chi Chuan (TCC) on physical psychological health college students.Two hundred six students were recruited randomly allocated to a control group or TCC exercise in an equal ratio. Participants instructed maintain their original activity level those received 12 weeks training based level. Physical outcomes evaluated at baseline, 13 25 weeks. Intention-to-treat analysis was performed for above outcomes.Compared with group, showed significant...
ABSTRACT Background Human donor kidneys release (pro)renin, erythropoietin (EPO), active vitamin D, and urodilatin during normothermic machine perfusion (NMP). However, whether the endocrine function of is associated with post‐transplant kidney unclear. Methods We studied 28 kidneys, including seven from donation after brain death (DBD) donors 21 circulatory (DCD) donors. Prior to transplantation, we measured levels EPO, 1,25(OH) 2 D in perfusate, urine NMP. Hormone rates were compared...
The atherogenic index of plasma (AIP) is a simple and reliable marker insulin resistance closely associated with various cardiovascular diseases (CVDs). However, the relationships between AIP left ventricular (LV) geometric indicators have not been adequately assessed. This study was carried out to investigate association LV abnormalities in obstructive sleep apnea (OSA) patients.
The physical and mental health of college-age youths tends to continuously decline around the world. It is therefore important promote during this period. As a traditional Chinese mind-body exercise, Tai Chi Chuan (TCC) may be an available selection. However for college student population, evidence unclear as whether TCC can recommended effective exercise promoting their psychological wellbeing. Therefore high quality, rigorous, prospective, well-controlled randomized trials are needed...
ZnT8 is a zinc transporter enriched in pancreatic β-cells, and its polymorphism associated with increased susceptibility to type 2 diabetes. However, the exact role of systemic energy metabolism remains elusive. In this study, we found that knockout mice displayed adiposity without obvious weight gain. We also observed intestinal tract morphology, motility, gut microbiota were changed mice. Further study demonstrated was expressed enteroendocrine cells, especially 5-hydroxytryptamine...
Background/Purpose Currently, there are no effective tools to accurately assess acute biliary pancreatitis (ABP) risk in patients with gallstones. This study aimed develop an ABP nomogram symptomatic Methods We conducted a retrospective nested case-control and data on 816 conservatively treated gallstones admitted The First Affiliated Hospital of Harbin Medical University between January 6, 2007 22, 2016 were retrospectively collected. propensity-score matched (PSM) analysis based follow-up...
Mortality in COVID-19 cases was strongly associated with progressive lung inflammation and eventual sepsis. There is mounting evidence that live attenuated vaccines commonly administered during childhood, also provide beneficial non-specific immune effects, including reduced mortality hospitalization due to unrelated infections. It has been proposed vaccine-associated effects are a result of inducing trained innate immunity function more effectively against broader In support this, our...
Abstract Myocardial injury induced by ischemia–reperfusion (I/R) remains a difficult clinical problem. However, the exact mechanisms underlying I/R‐induced have yet to be clarified. CARD9 is an important cytoplasmic‐binding protein. In this study, immunocoprecipitation assay showed that SUMOylation of protein promoted binding HOXB5, but hindered O‐GlcNAc glycosylation predicted transcription factor Parkin and key in mitophagy. signal for translocation proteins from cytoplasm nucleus....
High plasma LDL cholesterol (LDL-c) concentration is a major risk factor for atherosclerosis. Hepatic receptor (LDLR) regulates metabolism, and thereby LDL-c concentration. Recently, we have identified the (pro)renin [(P)RR] as novel regulator of which LDLR degradation hence its protein abundance activity. In silico analysis suggests that (P)RR target miR-148a. this study determined whether miR-148a could regulate metabolism by regulating expression in HepG2 Huh7 cells. We found suppressed...
Objective This study aims to explore whether body mass index (BMI) level affects the executive function and hippocampal subregion volume of subjective cognitive decline (SCD). Materials methods A total 111 participants were included in analysis, including SCD (38 normal BMI, 27 overweight obesity) control (NC) (29 17 obesity). All subjects underwent Chinese version Stroop Color-Word Test (SCWT) measure a high-resolution 3D T1 structural image acquisition. Two-way ANOVA was used examine...
Normothermic machine perfusion (NMP) is an alternative to hypothermic (HMP) for donor kidney preservation before transplantation. Contrary HMP, NMP allows functional assessment of kidneys because normothermic conditions allow metabolic activity. The are key producers hormones. Yet, it remains unknown whether during display endocrine functions.Fifteen were subjected HMP followed by 2 h perfusate was collected at 3 time points (0, 1, h) the measurements prorenin/renin, erythropoietin (EPO),...
Glucocorticoids (GCs) are widely used in various autoimmune diseases. Side effects may occur patients with long-term or high-dose GC usage. Among them, steroid myopathy and osteonecrosis two severe forms. We report a patient pemphigus vulgaris on GC-treatment who developed muscle weakness when cumulative dose of methylprednisolone reached about 20g (14-80mg/d for 2.5 years). Laboratory tests showed slightly elevated lactate dehydrogenase hydroxybutyrate dehydrogenase. MRI revealed the...
Abstract This study aimed to determine whether endoplasmic reticulum (ER) stress is involved in impaired autophagy after myocardial ischemia/reperfusion (M-I/R) and elucidate the underlying mechanisms. The expression levels of stimulator interferon gene (STING) regulatory transcription factor 3 (IRF3) phosphorylation increased M-I/R heart tissues hypoxia-treated/reoxygenation-treated H9c2 cells. ER inhibitor 4-phenylbutyric acid (4-PBA) significantly suppressed stimulation STING-IRF3...
Minichromosome maintenance complex component 7 (MCM7) belongs to the minichromosome family that is necessary for initiation of eukaryotic DNA replication. Overexpression MCM7 protein linked cellular proliferation and accountable critical malignancy in many cancers. Mechanistically, suppression greatly lowers associated with cancer. Advances immunotherapy have revolutionized treatments types To date, no effective small molecular candidate has been found can stop advancement cancer produced by...
Objective: Elevated plasma cholesterol concentrations contributes to ischemic cardiovascular diseases. Recently, we showed that inhibiting hepatic (pro)renin receptor [(P)RR] attenuated diet-induced hypercholesterolemia and hypertriglyceridemia in low-density lipoprotein (LDLR) deficient mice. The purpose of this study was determine whether (P)RR could attenuate atherosclerosis. Approach Results: Eight-week-old male LDLR-/- mice were injected with either saline or...