A5101815062- Gastrointestinal motility and disorders
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Acute Myeloid Leukemia Research
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Extracellular vesicles in disease
- Nutritional Studies and Diet
- Multiple Myeloma Research and Treatments
- Thermal Regulation in Medicine
- Circular RNAs in diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Cancer-related molecular mechanisms research
- Medical Research and Treatments
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- Osteoarthritis Treatment and Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Blood Pressure and Hypertension Studies
- Hepatitis B Virus Studies
- Glutathione Transferases and Polymorphisms
- Spinal Hematomas and Complications
Fujian University of Traditional Chinese Medicine
2021-2025
Guangzhou Medical University
2011-2024
Hubei University of Medicine
2024
Nanjing Drum Tower Hospital
2024
Nanjing University of Chinese Medicine
2024
Second Affiliated Hospital of Guangzhou Medical University
2011-2024
North China Electric Power University
2024
Shaanxi Provincial People's Hospital
2013-2024
Shanxi Medical University
2013-2024
Wuhan University
2024
Objective To investigate the efficacy and safety of telitacicept treatment in a Chinese SLE cohort, with real-life settings. Methods All patients who were receiving at least 4 weeks included, followed up. Patients received subcutaneous injection weekly based on standard treatment. responder index-4 (SRI-4) was assessed before first administration after administration. Disease flares during follow-up period defined as an increase disease activity number or dose immunosuppressive drugs....
Abstract Background and Aim Metabolic dysfunction‐associated steatotic liver disease (MASLD) is recently introduced to better highlight the pathogenic significance of cardiometabolic dysfunction, as compared with non‐alcoholic fatty disease. This study aimed investigate association between low thyroid function MASLD in new context. Methods We recruited 2901 participants for our retrospective cohort from 2016 2021. Participants were divided into strict‐normal groups (low‐normal function,...
Artificial intelligence (AI) for fluid mechanics has become attractive topic. High-fidelity data is one of most critical issues the successful applications AI in mechanics, however, it expensively obtained or even inaccessible. This study proposes a high-efficient forward generation method from partial differential equations (PDEs). Specifically, solutions PDEs are first generated either following random field (e.g. Gaussian field, GRF, computational complexity O(NlogN), N number spatial...
This study proposes a high-efficient machine learning (ML) projection method using forward-generated data for incompressible Navier-Stokes equations. A Poisson neural network (Poisson-NN) embedded and wavelet transform convolutional multigrid (WTCNN-MG) are proposed, integrated into the framework in patchwork overall differentiable manners with MG method, respectively. The solution of pressure equation split from equations is first generated either following random field (e.g. Gaussian...
Knee osteoarthritis (KOA) has been linked to increased cognitive decline risk, but the specific mechanisms underlying this phenomenon remain unclear. Research suggests neuroimaging changes and chronic low-grade inflammation may play key roles as common pathways linking (OA) decline. This cross-sectional study recruited 36 individuals diagnosed with KOA 25 healthy controls (HCs). Cognition was assessed using Montreal Cognitive Assessment (MoCA) Digit Cancellation Test (DCT). The gray matter...
Recently, chronic obstructive pulmonary disease (COPD) has been considered as a common risk factor of non-small cell lung cancer (NSCLC). However, very few studies have conducted on the effects COPD microbiota in patients with NSCLC. To identify and NSCLC (CN), microbiome induced sputa 90 was analyzed using 16S rDNA sequencing. The results showed no significant differences bacterial diversities among COPD, NSCLC, CN intrinsic different pathological types cancer. After surgical operation,...
Lung cancer is the leading cause of cancer-related mortality worldwide and cigarette smoking reported to contribute lung mortality. The present study aimed investigate molecular mechanism underlying nicotine-induced chemoresistance in cancer. expression microRNA (miR)-21-3p its predicted target FOXO3a cells was detected via reverse transcription-quantitative PCR, presence or absence nicotine. regulatory effect miR-21-3p on cell proliferation apoptosis induced by docetaxel cisplatin treatment...
The aims of the present study were to examine signaling mechanisms for transforming growth factor-β1 (TGF-β1)-induced rat airway smooth muscle cells (ASMCs) proliferation and migration determine effect lipoxin A4 (LXA4) on TGF-β1-induced ASMCs its underlying mechanisms. TGF-β1 upregulated transcriptional coactivator Yes-associated protein (YAP) expression by activating Smad2/3 then cyclin D1, leading migration. This was reversed after treatment with receptor inhibitor SB431542. YAP is a...
Patients with knee osteoarthritis (KOA) often suffer from cognitive decline and increased dementia risk, but the neurobiological mechanisms remain unclear. In this study, we evaluated performance collected brain magnetic resonance imaging (MRI) data blood samples cognitively normal KOA patients at baseline sessions reevaluated their cognition after 5 years. We also MRI matched healthy controls. Results showed that exhibited dysregulated functional connectivities between hippocampus...
Extracellular vesicles (EVs) have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins (RNPs), owing to their ability minimize off-target effects and immune responses. However, enhancements are required boost the efficiency safety of Cas9 RNP enrichment within EVs. In response, we employed Fc/Spa interaction system, in which human Fc domain was fused intracellular PTGFRN-Δ687 anchored EV membrane. Simultaneously, B Spa protein C cargos such Cre or spCas9. Due...
To analyze the effect of early enteral nutrition on serum inflammatory factors and intestinal mucosal permeability in patients with severe acute pancreatitis.A total 55 pancreatitis were divided into 2 groups: control group (n = 27), who received routine treatment observation 28), nutrition. The expression mucosa compared between groups before after treatment, rates infection mortality within 30 days statistically analyzed.The recovery duration urine amylase length hospital stay shorter than...
Objective This study aims to explore whether body mass index (BMI) level affects the executive function and hippocampal subregion volume of subjective cognitive decline (SCD). Materials methods A total 111 participants were included in analysis, including SCD (38 normal BMI, 27 overweight obesity) control (NC) (29 17 obesity). All subjects underwent Chinese version Stroop Color-Word Test (SCWT) measure a high-resolution 3D T1 structural image acquisition. Two-way ANOVA was used examine...
A class of adhesion protein that occurs in the membrane with both extracellular and intracellular domain play vital role maintaining multicellularity is TRASK, also called CUB-domain containing protein1, CD318 (CDCP1). Specifically, current study, documented aggressive grades lung cancers distant metastatic tissues were examined for interactions Trask compared cancer variants situ. The has ability to undergo tyrosine phosphorylation thereafter increased genomic expression, as well interact...
To investigate the relationship between hypertension status, hippocampus/hippocampal subregion structural alteration, and cognitive performance in subjective decline (SCD). All participants were divided into two groups according to blood pressure status: SCD without with hypertension. The assessments T1-MPRAGE brain MRI performed measure function volume of hippocampus hippocampal subregions. Association mediating/moderating effects analyzed subregions scores. Compared hypertension, we found...