A5088115225- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Global Health Care Issues
- Occupational and environmental lung diseases
- Air Quality Monitoring and Forecasting
- Noise Effects and Management
- Asthma and respiratory diseases
- Energy and Environment Impacts
- Occupational exposure and asthma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- COVID-19 epidemiological studies
- Thermoregulation and physiological responses
- Atmospheric chemistry and aerosols
- Nutritional Studies and Diet
- Global Cancer Incidence and Screening
- Smoking Behavior and Cessation
- Radiation Dose and Imaging
- Eicosanoids and Hypertension Pharmacology
- Occupational Health and Safety Research
- Atmospheric aerosols and clouds
- Neuroscience of respiration and sleep
- Health disparities and outcomes
- Thermal Regulation in Medicine
- Cardiovascular Function and Risk Factors
Chinese University of Hong Kong
2014-2025
Johnson & Johnson (Singapore)
2024
China Railway Eryuan Engineering Group Co.
2024
China Railway Group (China)
2024
Children's Hospital of Zhejiang University
2023
The Fifth People’s Hospital of Suzhou
2021-2022
Shanghai Mental Health Center
2022
Ocean University of China
2018-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2021
Janssen (United States)
2017-2021
Leukotrienes (LT) are a group of proinflammatory lipid mediators that implicated in the pathogenesis and progression atherosclerosis. Here we report mRNA levels for three key proteins LTB4 biosynthesis, namely 5-lipoxygenase (5-LO), 5-LO-activating protein (FLAP), LTA4 hydrolase (LTA4H), significantly increased human atherosclerotic plaque (n = 72) as compared with healthy controls 6). Neither LTC4 synthase nor any LT receptors exhibits levels. Immunohistochemical staining revealed abundant...
Many epidemiological studies have linked daily counts of hospital admissions to particulate matter (PM) with an aerodynamic diameter ≤ 10 μm (PM10) and 2.5 (PM2.5), but relatively few investigated the relationship coarse PM (PMc; 2.5-10 diameter).We conducted this study estimate health effects PMc on emergency for respiratory diseases in Hong Kong after controlling PM2.5 gaseous pollutants.We a time-series analysis associations between from January 2000 December 2005 concentrations. We...
<h3>Background</h3> Epidemiological research on the effects of coarse particles (PM<sub>c</sub>, particulate matter between 2.5 and 10 μm in aerodynamic diameter) respiratory morbidity is sparse inconclusive. Pneumonia an inflammatory condition lung caused by infections, which may be triggered exacerbated PM<sub>c</sub> exposure. <h3>Aim</h3> To estimate effect emergency hospital admissions for pneumonia after controlling PM<sub>2.5</sub> gaseous pollutants. <h3>Method</h3> concentrations...
Associations between ambient temperature and cardiovascular morbidity have been well studied worldwide; however, few studies determined the disease burden attributable to temperature. We aimed assess risk attributed based on exposure-lag-response relationship circulatory diseases.We collected daily time series data of emergency hospital admissions, mean temperature, air pollution concentrations from January 2005 December 2012 in Hong Kong. The association with was modeled using a distributed...
Abstract Background Physical activity (PA) is beneficial to human health, whereas long-term exposure air pollution harmful. However, their combined effects remain unclear. We aimed estimate the (interactive) mortality of PA and fine particulate matter (PM2.5) among older adults in Hong Kong. Methods Participants aged ≥65 years from Elderly Health Service Cohort (n = 66 820) reported habitual at baseline (1998–2001) were followed up till 31 December 2011. used a satellite-based spatiotemporal...
We examined the role of aerosol transmission influenza in an acute ward setting.We investigated a seasonal A outbreak that occurred our general medical (with open bay layout) 2008. Clinical and epidemiological information was collected real time during outbreak. Spatiotemporal analysis performed to estimate infection risk among patients. Airflow measurements were conducted, concentrations hypothetical virus-laden aerosols at different locations estimated using computational fluid dynamics...
Tissue fibrosis represents one of the largest groups diseases for which there are very few effective therapies. In heart, myocardial infarction (MI) resulting in loss cardiac myocytes can culminate adverse remodeling leading to eventual heart failure. Adverse includes myocyte hypertrophy, fibrosis, and electrical remodeling. We have previously demonstrated beneficial effects several potent soluble epoxide hydrolase inhibitors (sEHIs) different models hypertrophy Here, we directly determine...
The temporal and spatial distributions of the 2003 severe acute respiratory syndrome (SARS) outbreak in Amoy Gardens Hong Kong was reexamined using all confirmed cases. actually extended to nearby residential complexes. Airborne spread most likely explanation, SARS coronavirus could have over a distance 200 m.
Rationale: Recent experimental and clinical studies suggest that exogenous carbon monoxide (CO) at lower concentrations may have beneficial effects under certain circumstances, whereas population-based epidemiologic of environmentally relevant CO exposure generated mixed findings.Objectives: To examine the acute ambient on respiratory tract infection (RTI) hospitalizations.Methods: A time series study was conducted. Daily emergency hospital admission air pollution data in Hong Kong were...
Background Climate change increases global mean temperature and changes short-term (eg, diurnal) long-term intraseasonal) variability. Numerous studies have shown that variability are both associated with increased respiratory morbidity or mortality. However, data on the impact of sparse. Objective We aimed to assess association intraseasonal disease hospitalisations among elders. Methods ascertained first occurrence emergency hospital admissions for diseases in a prospective Chinese elderly...
We aimed to assess the association of long-term residential exposure fine particulate matter (PM) with aerodynamic diameter less than 2.5 μm (PM2.5) incidence stroke and its major subtypes.We ascertained first occurrence emergency hospital admission for in a Hong Kong Chinese cohort 66,820 older people (65+ years) who enrolled during 1998-2001 (baseline) were followed up December 31, 2010. High-resolution (1 × 1 km) yearly mean concentrations PM2.5 predicted from local monitoring data US...
Despite an increasing number of recent studies, the overall epidemiologic evidence associating specific particulate matter chemical components with health outcomes has been mixed. The links between and hospitalizations have rarely examined in Asia. We estimated associations exposures to 18 aerodynamic diameter less than 10 μm (PM10) daily emergency cardiorespiratory Hong Kong, China, 2001 2007. Carbonaceous matter, sulfate, nitrate, ammonium accounted for two-thirds PM10 mass. After...
Leukotriene (LT) B 4 is a powerful chemotactic and immune modulating agent that signals via two receptors denoted BLT 1 2 . Here we report are expressed at low levels in an apparently silent state human umbilical vein endothelial cells (HUVEC). However, treatment with LPS leads to >10 fold increase the of mRNA without any significant effects on mRNA. In parallel, also increases amounts protein. Tumor necrosis factor-α (TNF-α) expression ≈6 times above basal only modest Interleukin-1β...
Leukotrienes (LTs) are powerful proinflammatory lipid mediators that may play a central role in cardiovascular diseases, including arteriosclerosis, myocardial infarction, and stroke. Owing to restricted expression of 5-lipoxygenase (5-LO), the enzyme required for their synthesis, LTs almost exclusively produced by myeloid cells. Here, we report human cytomegalovirus (HCMV) infection vascular smooth muscle cells (SMCs) increases 5-LO mRNA levels up 170-fold dose- time-dependent manner....