A5033779816- Ginger and Zingiberaceae research
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Effects and Toxicity Studies
- Amino Acid Enzymes and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Membrane Separation Technologies
- Surface Modification and Superhydrophobicity
- Metabolism, Diabetes, and Cancer
- Polymer Surface Interaction Studies
- Plasma Applications and Diagnostics
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Mast cells and histamine
- Quinazolinone synthesis and applications
- Membrane-based Ion Separation Techniques
- Genomics, phytochemicals, and oxidative stress
- Chemical Reactions and Isotopes
- Sleep and Wakefulness Research
- Pharmacogenetics and Drug Metabolism
Hainan Medical University
2021-2025
Harbin Medical University
2020-2024
Third Affiliated Hospital of Harbin Medical University
2020-2024
Fulcrum Therapeutics (United States)
2024
UNSW Sydney
2024
University of Hong Kong
1997-2022
Chinese University of Hong Kong
1997-2022
Centre for Cancer Biology
2019
University of South Australia
2019
South Australia Pathology
2019
OBJECTIVE The proinflammatory cytokines/adipokines produced from adipose tissue act in an autocrine and/or endocrine manner to perpetuate local inflammation and induce peripheral insulin resistance. present study investigates whether lipocalin-2 deficiency or replenishment with this adipokine has any impact on systemic sensitivity the underlying mechanisms. METHODS AND RESULTS Under conditions of aging dietary-/genetic-induced obesity, knockout (Lcn2-KO) mice show significantly decreased...
Abstract Distant metastasis is the main cause of breast cancer-related death; however, effective therapeutic strategies targeting are still scarce. This largely attributable to spatiotemporal intratumor heterogeneity during metastasis. Here we show that protein deacetylase SIRT7 significantly downregulated in cancer lung metastases human and mice, predicts metastasis-free survival. deficiency promotes cell metastasis, while temporal expression Sirt7 inhibits polyomavirus middle T antigen...
Precise control of monoamine neurotransmitter levels in the extracellular fluids brain is critical maintaining efficient and robust neurotransmission. High affinity transporters solute carrier SLC6A family function removing monoamines from neurosynaptic cleft. Emerging evidence suggests that these are only one part a system work concert to maintain homeostasis monoamines. Here we report cloning characterization new human plasma membrane transporter, PMAT. The PMAT cDNA encodes protein 530...
Metformin is a widely used oral antihyperglycemic drug for the treatment of type II diabetes mellitus. The intestinal absorption metformin dose-dependent and involves an active, saturable uptake process. has been shown to be transported by human organic cation transporters 1 2 (hOCT1-2). We recently cloned characterized novel proton-activated transporter, plasma membrane monoamine transporter (PMAT). previously showed that PMAT transports many classic cations (e.g., neurotransmitters,...
Human equilibrative nucleoside transporter-3 (hENT3) was recently reported as a pH-dependent, intracellular (lysosomal) transporter capable of transporting anti-human immunodeficiency virus (HIV) dideoxynucleosides (ddNs). Because most anti-HIV ddNs (e.g., zidovudine, AZT) exhibit clinical mitochondrial toxicity, we investigated whether hENT3 facilitates transport into the mitochondria. Cellular fractionation and immunofluorescence microscopy studies in several human cell lines identified...
The growing epidemic of obesity, which causes nonalcoholic fatty liver disease (NAFLD) and the more severe phenotype steatohepatitis (NASH), has paralleled increasing incidence hepatocellular carcinoma (HCC). Accumulating evidence demonstrates that overnutrition metabolic pathways can trigger modifications DNA histones via deregulation chromatin modifiers, resulting in aberrant transcriptional activity. However, epigenetic regulation HCC development NAFLD remains obscure. Here, we uncover...
A novel method for synthesis and screening of fouling-resistant membrane surfaces was developed by combining a high-throughput platform (HTP) approach together with photoinduced graft polymerization (PGP) facile modification commercial poly(aryl sulfone) membranes. This is an inexpensive, fast, simple, reproducible, scalable to identify appropriate specific feed. In this research, natural organic matter (NOM)-resistant were synthesized indentified from library 66 monomers. Surfaces prepared...
Hypoxia in adipose tissue has been postulated as a possible contributor to obesity-related chronic inflammation, insulin resistance, and metabolic dysfunction. HIF1α (hypoxia-inducible factor 1α), master signal mediator of hypoxia response, is elevated obese tissue. However, the role pathologies remains be determined. Here we show that transgenic mice with tissue-selective expression dominant negative version developed more severe obesity were susceptible high fat diet-induced glucose...
DNA damage accumulates with age (Lombard et al., 2005). However, whether and how robust repair machinery promotes longevity is elusive. Here, we demonstrate that ATM-centered response (DDR) progressively declines senescence age, while low dose of chloroquine (CQ) activates ATM, clearance, rescues age-related metabolic shift, prolongs replicative lifespan. Molecularly, ATM phosphorylates SIRT6 deacetylase thus prevents MDM2-mediated ubiquitination proteasomal degradation. Extra copies Sirt6...
(R)-5-hydroxy-1,7-diphenyl-3-heptanone (DPHC) from the natural plant Alpinia officinarum has been reported to have antioxidation and antidiabetic effects. In this study, therapeutic effect molecular mechanism of DPHC on type 2 diabetes mellitus (T2DM) were investigated based regulation oxidative stress insulin resistance (IR) in vivo vitro. vivo, fasting blood glucose (FBG) level db/db mice was significantly reduced with improved tolerance sensitivity after 8 weeks treatment DPHC. vitro,...
AHP-3a, a triple-helix acidic polysaccharide isolated from Alpinia officinarum Hance, was evaluated for its anticancer and antioxidant activities. The physicochemical properties structure of AHP-3a were investigated through gel permeation chromatography, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy. weight-average molecular weight 484 kDa, with the molar percentages GalA, Gal, Ara, Xyl, Rha, Glc, GlcA, Fuc being...
Adiponectin is an adipocyte-derived hormone with a wide range of beneficial effects on obesity-related medical complications. Numerous epidemiological investigations in diverse ethnic groups have identified lower adiponectin level as independent risk factor for nonalcoholic fatty liver diseases and dysfunctions. Animal studies demonstrated that replenishment protects against various forms hepatic injuries, suggesting it to be potential drug candidate the treatment diseases. This study was...
Plasma membrane monoamine transporter (PMAT) is a novel recently cloned and characterized in our laboratory. We previously demonstrated that PMAT functions as polyspecific organic cation efficiently transports many cations such neurotransmitters 1-methyl-4-phenylpyridinium (MPP(+)). In this study, we explored the role of renal handling cations. Using polyclonal antibody generated toward NH(2)-terminal 66 amino acid residues human PMAT, showed protein (approximately 55 kDa) expressed kidney...
A novel high throughput method for synthesis and screening of customized protein-resistant surfaces was developed. This is an inexpensive, fast, reproducible scalable approach to synthesize screen appropriate a specific feed. The illustrated here by combining platform (HTP) together with our patented photo-induced graft polymerization (PGP) developed facile modification commercial poly(aryl sulfone) membranes. We demonstrate that the HTP-PGP fouling-resistant general, thus provides...
Spleen tyrosine kinase (SYK) is a key integrator of intracellular signals triggered by activated immunoreceptors, including Bcell receptors (BCR) and Fc receptors, which are important for the development function lymphoid cells. Given clinical efficacy depletion in treatment rheumatoid arthritis multiple sclerosis, pharmacological modulation Bcells using orally active small molecules that selectively target SYK presents an attractive alternative therapeutic strategy.A inhibitor was developed...
Abstract The aim of this work is to coat silk fibers (SF) with polymer acrylic acid (PAA) using an atmospheric pressure glow discharge (APGD) plasma jet in order immobilize antimicrobial peptide LL‐37. properties are characterized by contact angle goniometry (CAG), XPS, AFM and SEM. CA the SF film can be decreased 34°, surface roughness PAA center larger than other areas. Compared original SF, concentration carboxyl group increases greatly when modified Ar polymerization AA. augmentation...