A5100329374- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Synthesis and Reactions of Organic Compounds
- NF-κB Signaling Pathways
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Pharmacological Effects of Natural Compounds
- Plant biochemistry and biosynthesis
- Phytochemistry and Biological Activities
- Service-Oriented Architecture and Web Services
- Marine Sponges and Natural Products
- Ginseng Biological Effects and Applications
- Genomics, phytochemicals, and oxidative stress
- Morinda citrifolia extract uses
- Ziziphus Jujuba Studies and Applications
- Skin Protection and Aging
- Bioactive Natural Diterpenoids Research
- Innovative Teaching and Learning Methods
- Computational Drug Discovery Methods
- Learning Styles and Cognitive Differences
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Insect and Pesticide Research
Sungkyunkwan University
2008-2022
La Roche College
2013
Migration Institute of Australia
2009
Harvey Mudd College
2009
Grove City College
2009
Massachusetts Institute of Technology
2009
University of Toronto
2009
Indian Institute of Science Bangalore
2009
Korea University
2002-2009
Samsung Medical Center
2008
Although Korean Red Ginseng (KRG) has been traditionally used for a long time, its anti-inflammatory role and underlying molecular cellular mechanisms have poorly understood. In this study, the roles of KRG-derived components, namely, water extract (KRG-WE), saponin fraction (KRG-SF), nonsaponin (KRG-NSF), were investigated. To check levels in test fractions, KRG-WE, KRG-NSF, KRG-SF analyzed using high-performance liquid chromatography. The these components investigated macrophage-like cell...
Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only few studies have explored the molecular mechanism of KRG-mediated activity. We investigated mechanisms protopanaxadiol saponin fraction (PPD-SF) KRG using in vitro vivo inflammatory models. PPD-SF dose-dependently diminished release mediators [nitric oxide (NO), tumor necrosis...
Spleen tyrosine kinase (SYK) is a key integrator of intracellular signals triggered by activated immunoreceptors, including Bcell receptors (BCR) and Fc receptors, which are important for the development function lymphoid cells. Given clinical efficacy depletion in treatment rheumatoid arthritis multiple sclerosis, pharmacological modulation Bcells using orally active small molecules that selectively target SYK presents an attractive alternative therapeutic strategy.A inhibitor was developed...
Anthraquinone compounds are one of the abundant polyphenols found in fruits, vegetables, and herbs. However, vivo anti-inflammatory activity molecular mechanisms anthraquinones have not been fully elucidated. We investigated using acute inflammatory nociceptive experimental conditions. Anthraquinone-2-carboxylic acid (9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid, AQCA), major identified from Brazilian taheebo, ameliorated various algesic symptoms EtOH/HCl- acetylsalicylic acid- (ASA-)...
Six new saponins, five lupanes (1-5) and one oleanane (6), along with 11 known were isolated from the roots of Pulsatilla koreana. The structures saponins found to be 23-hydroxy-3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[O-beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic acid (1), 23-hydroxy-3beta-[(O-beta-D-glucopyranosyl-(1-->3)-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl)oxy]lup-20(29)-en-28-oic (2),...
2- or 6-(1-Hydroxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinone (DMNQ) and 6-(1-propyloxyimino- alkyl)-DMNQ derivatives were synthesized, their inhibitory effects on DNA topoisomerase-I (TOPO-I) antiproliferative activities against L1210 cells examined. In a comparison, it was found that 6-(1-hydroxyiminoalkyl)-DMNQ exhibited higher potencies in both bioactivities than 2-(1-hydroxyiminoalkyl)-DMNQ analogues, suggesting the difference between two positional isomers might be due to steric...
AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting a suppressor melanin synthesis tyrosinase expression. Since macrophage-mediated inflammatory responses are critical health, here we investigated potential anti-inflammatory activity AP736. The effects on various events such nitric oxide (NO)/prostaglandin (PG) E 2 production, gene expression, phagocytic uptake, morphological changes were examined RAW264.7...
Gouania leptostachya DC. var. tonkinensis Pitard. Rhamnaceae is a traditional medicinal plant used in Thailand for treating various inflammatory symptoms. However, no systematic studies have been performed concerning the anti-inflammatory effects or molecular mechanisms of this plant. The immunopharmacological activities methanol extract from leaves and twigs G. (Gl-ME) were elucidated based on gastritis symptoms mice treated with HCl/EtOH responses, such as nitric oxide (NO) release...
tory pathway-dependent feedback loops.Similar to other biological process, due its complexity of regulation, inflammation is not bulletproof and can produce errors.Such errors lead uncontrolled inflammatory responses that harm the body (Screaton et al., 2015).In fact, a prolonged incidence has been linked several diseases such as, cancer, diabetes, obesity (Lumeng Saltiel, 2011;Elinav 2013).Recently, our knowledge mediating molecules expanded from cytokines released immune cells...
Sort can be speeded up on parallel computers by dividing and computing data individually in parallel. Bitonic sorting parallelized, however, a great portion of execution time is consumed due to O(log/sup 2/P) exchange N/P keys where P, N are the number processors keys, respectively. This paper presents an efficient way communication bitonic sort minimize interprocessor comparison time. Before actual movement, each pair processor exchanges minimum maximum its list determine which sent...
Previous studies have demonstrated the role of hydroquinone (HQ), a hydroxylated benzene metabolite, in modulating various immune responses; however, its macrophage-mediated inflammatory responses is not fully understood. In this study, HQ and underlying molecular mechanism were explored macrophages. down-regulated expression interferon (IFN)-β mRNA LPS-stimulated RAW264.7 cells without any cytotoxicity suppressed regulatory factor (IRF)-3-mediated luciferase activity induced by...
Antiangiogenic activity-guided fractionation and isolation carried out on the methanol extract of Adonis amurensis led to identification three compounds, namely cymarin, cymarol, cymarilic acid. Amongst acid was isolated from this plant for first time. This compound showed no significant cytotoxicity against tumor cell lines but found be strongly inhibitory toward tube formation induced by human umbilical venous endothelial (HUVE) cells. Cymarin cymarol exhibited potent a solid line A549...
아열대성 작물을 대상으로 피해를 주는 해충에 대해서 친환경 소독 기술로서 환경조절열처리(CATTS: controlled atmosphere temperature treatment system) 기술이 개발되었다. 본 연구는 국내 사과를 일부 외국으로 수출할 경우 검역대상으로 지목받고 있는 복숭아심식나방(Carposina sasakii)에 CATTS 기술을 적용할 수 지에 대한 가능성을 알아보기 위해 시도되었다. 노출된 복숭아심식나방은 <TEX>$46^{\circ}C$</TEX>의 치사 설정온도에서 반수치사노출시간이 14.66 분으로 나타났다. 여기에 높은 농도의 이산화탄소 노출은 <TEX>$46^{\circ}C$</TEX>에 복숭아심식나방의 감수성을 현격하게 높였다. 다음으로 수확 후 사과 내부에서 가해하는 복숭아심식나방을 연구에서 제조된 장치로 소독효과를 분석하였다. 연구용 장비는 이산화탄소와 온도를 자동으로 조절하며 처리 기간 동안 기기 내부 및 과실 실시간으로 모니터링...
(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone (MPP) is an aldol condensation product resulting from pyrrole-2-carbaldehyde and m- p- substituted acetophenones. However, its biological activity has not yet been evaluated. Since it reported that some propenone-type compounds display anti-inflammatory activity, we investigated whether MPP could negatively modulate inflammatory responses. To do this, employed lipopolysaccharide (LPS)-stimulated macrophage-like RAW264.7 cells examined the...