A5102897747- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Food Quality and Safety Studies
- Agriculture, Soil, Plant Science
- Natural product bioactivities and synthesis
- Polysaccharides and Plant Cell Walls
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- melanin and skin pigmentation
- Genomics and Phylogenetic Studies
- Essential Oils and Antimicrobial Activity
- Skin Protection and Aging
- Ziziphus Jujuba Studies and Applications
- Hops Chemistry and Applications
- Microbial Community Ecology and Physiology
- Methane Hydrates and Related Phenomena
- Phytochemistry and Biological Activities
- Burkholderia infections and melioidosis
- Fungal Biology and Applications
- Botanical Research and Applications
- Hematopoietic Stem Cell Transplantation
- Galectins and Cancer Biology
- Carcinogens and Genotoxicity Assessment
- Nephrotoxicity and Medicinal Plants
- Chemical synthesis and alkaloids
Korean Society of Ginseng
2016-2025
KT&G (South Korea)
2004-2021
RIKEN
1994
Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated effects G-Rc on inflammatory responses in vitro examined mechanisms these effects.The inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-α/interferon-γ-treated synovial cells, HEK293 cells...
Red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng, displays immunostimulatory and antitumor activities. Even though numerous studies have been reported, the mechanism as to how RGAP is able stimulate immune response not clear. In this study, we aimed explore of molecular activation in macrophages. treatment strongly induced NO production RAW264.7 cells without altering morphological changes, although activity was strong compared LPS-induced dendritic-like morphology...
It has been reported that red ginseng acidic polysaccharide (RGAP), isolated from Korean ginseng, displays immunostimulatory and anti-tumor activities. In a follow-up study, we have carried out study on the anti-hyperlipidemic effects of RGAP using hyperlipidemic rats acutely induced by Triton WR1339 or corn oil intravenously injected. Oral administration (100 to 1000 mg/kg) dose-dependently reduced serum levels triglyceride (TG) up-regulated WR1339, an inducer endogenous model...
The chemical constituents of Panax ginseng are changed by processing methods such as steaming or sun drying. In the present study, change induced was monitored in situ. Samples were separated from same root incision during process, for situ monitoring. Sampling sequentially performed three stages; FG (fresh ginseng) → SG (steamed RG (red and 60 samples prepared freeze dried. then analyzed to determine 43 among stages P. ginseng. results showed that six malonyl-ginsenoside (Rg1, Rb1, Rb3, Rc,...
Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only few studies have explored the molecular mechanism of KRG-mediated activity. We investigated mechanisms protopanaxadiol saponin fraction (PPD-SF) KRG using in vitro vivo inflammatory models. PPD-SF dose-dependently diminished release mediators [nitric oxide (NO), tumor necrosis...
Korean Red Ginseng (KRG) is an herbal medicine prescribed worldwide that prepared from Panax ginseng C.A. Meyer (Araliaceae). Out of ginseng’s various components, ginsenosides are regarded as the major ingredients, exhibiting anticancer and anti-inflammatory activities. Although recent studies have focused on understanding activities KRG, compounds precisely how these can suppress inflammatory processes has not been fully elucidated yet. In this study, we aimed to identify inhibitory...
We have recently reported that red ginseng acidic polysaccharide (RGAP), isolated from Korean (Panax C.A. Meyer), shows immunomodulatory and antitumor activities, mainly mediated by the nitric oxide (NO) production of macrophages. This compound may be used in cancer therapy alone or combination with other chemotherapeutic agents. The synergistic effect RGAP paclitaxel (taxol) was evaluated to develop new biological response modifiers therapy. present study demonstrates a mice transplanted...
Korean Red Ginseng (KRG) is a traditional herb that has several beneficial properties including anti-aging, anti-inflammatory, and autophagy regulatory effects. However, the mechanisms of these effects are not well understood. In this report, underlying anti-inflammatory autophagy-promoting were investigated in aged mice treated with KRG-water extract (WE) over long period. The activities KRG-WE evaluated kidney, lung, liver, stomach, colon using semi-quantitative reverse transcription...
Beneficial effects of Korean Red Ginseng (KRG) on polycystic ovarian syndrome (PCOS) remains unclear.
Torilin, a sesquiterpene isolated from the fruits of Torilis japonica, has shown antimicrobial, anticancer, and anti-inflammatory properties. However, data on mechanism torilin action against inflammation is limited. This study aimed at determining property in LPS-induced using vitro model inflammation. We examined torilin’s effect expression levels inflammatory mediators cytokines LPS-stimulated RAW 264.7 macrophages. The involvement NF-kB AP-1, MAP kinases, adaptor proteins were assessed....
Hematopoiesis is the production of blood cells from hematopoietic stem (HSCs) that reside in bone marrow. Cyclophosphamide (CTX) a chemotherapy drug suppresses immune system. Korean Red Ginseng (KRG) and Colla corii asini (CCA) have been traditionally used for boosting system.HSCs marrow, cell subtype splenocytes, PBMCs, thymocytes were investigated. Serum levels hematopoietic-related markers analyzed using ELISA. Protein expression spleen tissue was western blot analysis. Hematoxylin &...
Despite a multitude of reports on anti-inflammatory properties ginseng extracts or individual ginsenosides, data antiarthritic effect saponin preparation with mixed ginsenosides is limited. On the other hand, combined therapy safe and inexpensive plant-derived natural products such as can be considered an alternative to treat arthritis. Our previous in vitro displayed strong action red fraction-A (RGSF-A). We, herein, report marked property RGSF-A rich ginsenoside Rb1, Rc, Rb2....