A5101754572- Food Quality and Safety Studies
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Agriculture, Soil, Plant Science
- Nutrition, Health and Food Behavior
- Phytochemicals and Antioxidant Activities
- Phytoestrogen effects and research
- Skin Protection and Aging
- Ocular Surface and Contact Lens
- Insect Utilization and Effects
- Protein Hydrolysis and Bioactive Peptides
- Fungal Biology and Applications
- Dyeing and Modifying Textile Fibers
- Meat and Animal Product Quality
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Fermentation and Sensory Analysis
- melanin and skin pigmentation
- Seed and Plant Biochemistry
- Alzheimer's disease research and treatments
- Natural product bioactivities and synthesis
- Diverse Approaches in Healthcare and Education Studies
- Phytase and its Applications
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
University of Lübeck
2024
Kiel University
2024
University Hospital Schleswig-Holstein
2024
Harvard University
2021-2024
Beth Israel Deaconess Medical Center
2021-2024
Translational Therapeutics (United States)
2021
Cancer Research Institute
2021
Kongju National University
2019-2021
Shanghai University of Traditional Chinese Medicine
2018-2020
KT&G (South Korea)
2008-2017
Andrographolide (Andro), a well-known labdane diterpenoid of Andrographis paniculata, has been reported to have anti-inflammatory effects in various inflammatory disease models. Despite ongoing efforts elucidate the mechanism Andro, its specific is not entirely clear. In this study, we confirmed inhibitory effect Andro on activity and studied depth find potential targets using lipopolysaccharide (LPS)-induced macrophages vitro dextran sulfate sodium (DSS)-induced mouse model acute colitis...
Reducing brain blood flow induces toxic but druggable cis P-tau that drives progressive neurodegeneration and memory loss in mice.
Introduction:Crocus sativus (saffron) is widely used in China, Iran, and India for dyeing as a food additive medicinal plant. Safranal, one of the main constituents saffron, responsible its aroma has been reported to have anticancer, antioxidant, anti-inflammation properties. Objective: In this study, we investigated anti-inflammatory effects Safranal RAW264.7 cells, bone marrow-derived macrophages (BMDMs), dextran sulfate sodium (DSS)-induced colitis mice. Methods: toxicity was determined...
Red ginseng contains many bioactive constituents, including various ginsenosides that are believed to have antioxidant, immunostimulatory, and anti-aging activities. Yet, no controlled human study has explored its effects on photoaged skin. This determined whether long-term intake of a red extract-containing Torilus fructus Corni mixture reduces facial wrinkles increases collagen synthesis in Healthy female volunteers over 40 years age were randomized double-blind fashion receive either...
To evaluate the efficacy and safety of a thermal massager for treatment dry eye syndrome.Ninety-five patients with syndrome were randomly assigned to receive either or artificial tears treatment. Thermal massage consisted vibration, thermotherapy was carried out twice daily. Patients in group received 0.1% sodium hyaluronate solution five times The Ocular Surface Disease Index (OSDI) score, break-up time (BUT), Schirmer test, fluorescein staining cornea, tear osmolarity test adverse events...
Torilin, a sesquiterpene isolated from the fruits of Torilis japonica, has shown antimicrobial, anticancer, and anti-inflammatory properties. However, data on mechanism torilin action against inflammation is limited. This study aimed at determining property in LPS-induced using vitro model inflammation. We examined torilin’s effect expression levels inflammatory mediators cytokines LPS-stimulated RAW 264.7 macrophages. The involvement NF-kB AP-1, MAP kinases, adaptor proteins were assessed....
Background and Purpose Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract, an impaired immune response plays critical role in IBD. The current drugs therapies for IBD treatment are limited use, therefore, there need to find novel or this disease. We investigated effect cambogin mouse model dextran sulphate sodium (DSS)‐induced colitis whether attenuates inflammation via Treg‐cell‐mediated on response. Experimental Approach Chronic was...
Cacao bean husk (Theobroma cacao L.) contains a high level of dietary fiber and therefore can be used as raw material in food processing. The objective the present study was to measure physicochemical properties sensory traits emulsion-type pork sausages with various levels powder (0.25%, 0.5%, 0.75%, 1%, 2%). moisture content cooked increased power increased, whereas protein decreased (p<0.05). With respect color, there decrease lightness yellowness, but considerable increase redness...
Tauopathies are neurodegenerative diseases characterized by deposits of abnormal Tau protein in the brain. Conventional tauopathies often defined a limited number epitopes, notably neurofibrillary tangles, but emerging evidence suggests structural heterogeneity among tauopathies. The prolyl isomerase Pin1 isomerizes cis P-tau to inhibit development oligomers, tangles and neurodegeneration multiple such as Alzheimer’s disease, traumatic brain injury, vascular contribution cognitive impairment...
Ultraviolet (UV) irradiation induces skin dryness, largely by disruption of the epidermal barrier. In a search for dietary and plant compounds that would protect against we investigated effect red ginseng (the steamed root Panax C.A. Meyer) on levels hydration ceramides, most important lipids maintaining barrier, in UV-irradiated mice. Albino hairless mice were fed either control diets (group UV [UV-irradiated control]) or with 0.5% H0.5) 1% H1.0) extract 5 weeks parallel irradiation. A...
Macrophages-involved inflammation is considered to induce the damage in various diseases. Herein, novel therapeutics inhibiting over-activation of macrophages could prove an effective strategy prevent inflammation-related Gaudichaudione H (GH), which a natural small molecular compound isolated from Garcinia oligantha Merr. (Clusiaceae) has previously been demonstrated its anti-cancer effects on several cancer cell lines. However, no report published about anti-inflammatory effect GH date....
Purpose:To evaluate the effect of epiblepharon surgery on visual acuity and with-the-rule astigmatism in children compared to patients without surgical treatment.Methods: We undertook a retrospective case control study reviewed charts 202 eyes treated with 142 surgery.The procedure for correction used rotating suture techniques.Data regarding age, best corrected acuity, degree were recorded.Baseline 1-, 3-, 6-, 12-month postoperative data collected.The chi-square test, Student's t-test...
<b><i>Aims:</i></b> To evaluate the biologic effects of fluoroquinolone eye solutions without preservatives on cultured human corneal epithelial cells in vitro. <b><i>Methods:</i></b> We studied effect diverse generations topical fluoroquinolones such as ofloxacin 0.3%, levofloxacin 0.5%, tosufloxacin moxifloxacin 0.5% and gatifloxacin 0.3% cells. MTT-based calorimetric assay, lactate dehydrogenase leakage (LDH) assay scratch wound test were...
홍삼과 보이차, 노팔선인장을 소재로 하여 체중조절효과가 우수하고 부작용이 없는 최적의 원료와 적정 섭취 농도를 설정하고자 홍삼, 노팔선인장 혼합소재(DM1) 및 보이차 혼합소재(DM2)를 고지방식이로 8주간 비만을 유도한 수컷 흰쥐에게 100, 300, 500 ㎎/㎏의 농도로 투여하면서 체중, 혈중 지질 분석, 복부 기타지방 조직, 비만에 관련된 몇 가지 생화학적 지표를 조사하였고, 간 기능과 신장 기능, 조혈 기능을 나타내는 조사하였다. 체중은 고지방식이군에 비하여 DM1 투여군에서 77.1～51.8%, DM2 64.7～16.1% 수준으로 증가하였다. 중성 지질의 농도는 고지방 식이군의 84～54%, 62～58%의 수준을 나타내었다. 혈청 렙틴의 농도 의존적으로 감소하여 고지방식이군의 82.8～66.9%로 감소되었다. 인슐린의 66.8～65.1%, 66.7～62.5%의 수준이었으며 1% 수준에서 통계적인 유의성을 부고환 주위지방(좌/우), 내장지방, 신장주위 지방의 무게는...
Purpose: To investigate changes in the photoreceptor layer tissue images using spectral-domain optical coherence tomography after macular hole surgery. Methods: Visual acuity and scans were obtained 24 eyes with surgically closed holes prospectively at 1, 2, 4, 6 months The scanned data processed to generate of layer, namely, map. Hyporeflective area reflectivity fovea analyzed find a correlation visual acuity. Results: Mean improved from 48.1 letters preoperatively 62.5 1 month 73.8 months....
눈꽃동충하초(Paecilomyces japonica)를 이용한 새로운 약용민속주를 개발하기 위하여 먼저 알콜발효조건을 검토하였다. 1.0%의 눈꽃동충하초를 함유한 덧밥에 코지를 10%첨가하고 Saccharomyces cerevisiae를 이용하여 제조한 주모를 첨가한 후 <TEX>$25^{\circ}C$</TEX>에서 15일간 발효 시켰을 때 에탄올이 가장 많이 생성되었다. 0.1%, 0.5%, 1.0%, 2.0%씩 각각 첨가하여 동충하초 민속주들의 관능검사와 생리기능성을 조사한 결과 0.1% D-1 눈꽃동충하초 민속주가 기호도가 제일 높았고 혈전용해활성과 아질산염 제거 작용이 11.2U와 19.8%로 대조구인 동충하초를 첨가하지 않고 민속주보다 우수하였다. In order to develop a new traditional liquor by using Paecilomyces japonica, alcohol fermentation condition was...
In this study, the authors have characterized effect of HER-S (red ginseng, Angelicae gigantis Radix, Phyllostachys folium, and soybean extracts) on osteoporosis-associated phenomena in ovariectomized (OVX) rats by measuring body weights bone histomorphometries control, sham, OVX, OVX(beta-estradiol-treated), OVX(HER-S-treated) rats. Light microscopic analyses showed a porous or eroded appearance femoral trabecular surface OVX rats, whereas surfaces other groups (control,...
Cacao bean husks, removed from roasted cacao beans, account for 10∼15% of the composition beans and contain 3% polyphenols consisting catechin, epicatechin, procyanidin.This study examined quality antioxidant activity husk powder in cookies prepared with different concentrations (1%, 2%, 3%, 5% total material).The was estimated by DPPH-ABTS + assay, determining polyphenol flavonoid content powder.To evaluate characteristics, we measured bulk density pH dough, moisture content, spread factor,...
Inflammatory bowel disease (IBD) is associated with perturbed metabolism of the essential amino acid tryptophan (Trp). Whether increased degradation Trp directly fuels mucosal inflammation or acts as a compensatory attempt to restore cellular energy levels via