A5100327695- Animal Nutrition and Physiology
- Coccidia and coccidiosis research
- Veterinary medicine and infectious diseases
- Ginseng Biological Effects and Applications
- T-cell and Retrovirus Studies
- Food Quality and Safety Studies
- Immune Cell Function and Interaction
- Agriculture, Soil, Plant Science
- Pharmacological Effects of Natural Compounds
- Macrophage Migration Inhibitory Factor
- Aquaculture disease management and microbiota
- Wound Healing and Treatments
- Osteoarthritis Treatment and Mechanisms
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Microbial infections and disease research
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Silk-based biomaterials and applications
- IL-33, ST2, and ILC Pathways
Sungkyunkwan University
2011-2025
Samsung Medical Center
2024-2025
Korea Advanced Institute of Science and Technology
2023
Royal Veterinary College
2020-2022
Korean Society of Ginseng
2020-2022
Roslin Institute
2015-2021
University of Edinburgh
2015-2021
Seoul National University
2007-2021
National Cancer Center
2021
KT&G (South Korea)
2020
A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided cost-effective assembly the genome sequence domestic turkey (Meleagris gallopavo). Heterozygosity sequenced source allowed discovery more than 600,000 high quality single nucleotide variants. Despite this heterozygosity, current (∼1.1 Gb) includes 917 Mb assigned to specific chromosomes. Annotation identified nearly 16,000 genes, 15,093 recognized as protein...
Probiotics are live, nonpathogenic microorganisms known to have a positive effect on the host by improving natural balance of gut microbiota. The objective this study was determine effects administering probiotics (Primalac W/S) in ovo hatchability, early post-hatch performance, and intestinal immune-related gene expression broiler chicks. At embryonic day eighteen, 360 Cobb 500 eggs were injected with sterile water (sham), 1 × 105, 106, or 107 (P1, P2, P3 respectively) probiotic bacteria....
Escalating consumer concerns regarding pathogen resistance have placed the poultry industry under mounting pressure to eliminate use of chemotherapeutic agents as feed additives. One possible alternative receiving increased attention is immunomodulators such β-glucan. A study was conducted investigate effects a yeast-derived β-glucan (Auxoferm YGT) on broiler chick performance, lesion scores, and immune-related gene expression during mixed Eimeria infection. Day-old chicks were fed diets...
Abstract Introduction Gene amplification is an important mechanism for activating oncogenes in malignant tumors. Although of HER2 , C-MYC CCND1 and FGFR1 has been reported breast cancers, their role the progression situ to invasive carcinoma unclear. To investigate this question we compared frequencies these genes pure ductal (DCIS), DCIS associated with carcinoma, carcinoma. Methods We performed fluorescence hybridization selected on tissue microarrays composed 179 438 carcinomas. Two...
During the first week posthatch, avian immune system is immature and inefficient at protecting chicks from invading pathogens. Among immunomodulators, beta-glucans are known as biological response modifiers due to their ability activate system. Current research suggests that may enhance immunity; however, very little about influence on regulation of function. A study was performed evaluate effects dietary beta-glucan growth performance, organ weights, peripheral blood cell profiles,...
The COVID-19 pandemic highlighted the need for rapidly deployable, flexible vaccine platforms; particularly RNA which is now being explored several other pathogens. DNA vaccines have potential advantages over RNA, including cost of manufacture, ease storage and potentially lower reactogenicity. However, they historically underperformed in large animals human trials due to low immunogenicity. interplay between antigen expression innate immune response impacts overall vaccines. Here, we...
Background/Objectives: Cerebellum might be one of the targets repetitive transcranial magnetic stimulation (rTMS) for motor recovery in stroke patients. The aim this study was to investigate enhancing effects rTMS over cerebellum on inhibitory patients with subacute ischemic stroke. Methods: Twenty-three were recruited into single-blind randomized, controlled a blinded observer. Cr-Cbll group received consisting continuous theta burst contralesional primary cortex (M1), shoulder mobilization...
Coccidiosis is regarded as the parasitic disease with greatest economic impact on poultry industry due to reduced performance and increased mortality. A study was conducted investigate effects of in ovo administration probiotics hatchability, performance, immune organ weights, lesion scores broiler chicks during a mixed Eimeria infection. At embryonic day 18, 210 eggs were injected either sterile water or 1×10 6 cfu probiotic bacteria. On 3 post-hatch, half from each treatment group...
Associations between a wide variety of diseases and the microbiome have been extensively verified. Recently, there has rising interest in role plays atopic dermatitis (AD). Furthermore, metagenomic analysis microbe-derived extracellular vesicles (EVs) revealed importance relevance microbial EVs human health.
Eimeria maxima is a common cause of coccidiosis in chickens, disease that has huge economic impact on poultry production. Knowledge immunity to E. and the specific mechanisms contribute differing levels resistance observed between chicken breeds congenic lines derived from single breed chickens required. This study aimed define differences kinetics immune response two inbred White Leghorn exhibit differential (line C.B12) or susceptibility 15I) infection by . Line C.B12 15I were infected...
Restoring hair follicles by inducing the anagen phase is a promising approach to prevent loss. Hair follicle dermal papilla cells (HFDPCs) play major role in growth via telogen-to-anagen transition. The therapeutic effect of Morus alba activates β-catenin HFDPCs, thereby phase. HFDPCs were treated with M. root extract (MARE) promote growth. It contains chlorogenic acid and umbelliferone not cytotoxic at concentration 20%. was demonstrated that small amount MARE enhances factor secretion...
Cheap, easy-to-produce oral vaccines are needed for control of coccidiosis in chickens to reduce the impact this disease on welfare and economic performance. Saccharomyces cerevisiae yeast expressing three Eimeria tenella antigens were developed delivered as heat-killed, freeze-dried whole four separate studies. After vaccination, E. replication was reduced following low dose challenge (250 oocysts) Hy-Line Brown layer (p<0.01). Similarly, caecal lesion score vaccinated using a mixture S....
Recently, there has been a rise in the interest to understand composition of indoor dust due its association with lung diseases such as asthma, chronic obstructive pulmonary disease (COPD) and cancer. Furthermore, it found that bacterial extracellular vesicles (EVs) within particles can induce inflammation, suggesting these might play role disease.We performed microbiome analysis EVs isolated from mattresses apartments hospitals. We developed diagnostic models based on antibodies detected...
Abstract Background Poultry coccidiosis is a parasitic enteric disease with highly negative impact on chicken production. In-feed chemoprophylaxis remains the primary method of control, but increasing ineffectiveness anticoccidial drugs, and potential future restrictions their use has encouraged commercial live vaccines. Availability such formulations constrained by production, which relies chickens. Several experimental approaches have been taken to explore ways reduce complexity cost...
Adult T cell leukemia/lymphoma (ATL) is a highly aggressive hematologic malignancy with very poor prognosis, and most patients ATL are elderly. Although post-transplantation cyclophosphamide (PTCy) has yielded promising results in various diseases, available data limited regarding its outcomes ATL. The aim of this study was to determine the safety efficacy reduced-intensity peripheral blood stem transplantation (PBSCT) from human leukocyte antigen (HLA)-haploidentical donor using PTCy as...
Abstract Influenza virus represents a challenge for traditional vaccine approaches due to its seasonal changes and potential zoonotic transmission. Nucleic acid vaccines can overcome some of these challenges, especially through the inclusion multiple antigens increase breadth response. RNA were an important part response COVID-19 pandemic, but future outbreaks DNA may have advantages in terms stability manufacturing cost that warrant continuing investigation fully realise their potential....
Asthma is an incurable hyper-responsive disease of the pulmonary system that caused by various allergens, including indoor and outdoor stimulators. According to Global Network, 339 million people suffered from asthma in 2018, with particularly severe forms children. Numerous treatments for are available; however, they frequently associated adverse effects such as growth retardation, neurological disorders (e.g., catatonia, poor concentration, insomnia), physiological immunosuppression,...