A5002825827- Mycotoxins in Agriculture and Food
- Carcinogens and Genotoxicity Assessment
- Plant Toxicity and Pharmacological Properties
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Vanadium and Halogenation Chemistry
- Insect and Pesticide Research
- Air Quality and Health Impacts
- Environmental Toxicology and Ecotoxicology
- Pharmacogenetics and Drug Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Plant and fungal interactions
- Microbial infections and disease research
- Indoor Air Quality and Microbial Exposure
- Aquaculture disease management and microbiota
- Animal Nutrition and Physiology
- Energy and Environment Impacts
- Aquaculture Nutrition and Growth
- Pesticide Exposure and Toxicity
- Wheat and Barley Genetics and Pathology
- Botanical Research and Chemistry
- Nitric Oxide and Endothelin Effects
- Free Radicals and Antioxidants
- Marine Toxins and Detection Methods
- Plant Genetic and Mutation Studies
Utah State University
2010-2025
Colorado State University
1993-1999
Dairy Management
1989
Centre hospitalier de l'Université Laval
1986
Oregon State University
1982-1984
University of California, Davis
1984
University of Idaho
1982
A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided cost-effective assembly the genome sequence domestic turkey (Meleagris gallopavo). Heterozygosity sequenced source allowed discovery more than 600,000 high quality single nucleotide variants. Despite this heterozygosity, current (∼1.1 Gb) includes 917 Mb assigned to specific chromosomes. Annotation identified nearly 16,000 genes, 15,093 recognized as protein...
This review is a comprehensive introduction to the effects of poultry exposure toxic and carcinogenic mycotoxin aflatoxin B1 (AFB1). The relationship between AFB1 sensitivity metabolism, major direct indirect AFB1, recent studies gene expression transcriptome responses exposure, mitigation strategies reduce toxicity are discussed. Exposure primarily occurs by consumption contaminated corn, grain or other feed components. Low levels residual in feeds can cause reduction growth, conversion,...
Recent studies have shown that alveolar macrophages (AM) are able to release leukotrienes (LTs). Since cigarette smoking inhibits the cyclooxygenase pathway of arachidonic acid metabolism in AM, we evaluated LT production by AM from smokers and nonsmokers. were obtained 35 volunteers, 16 nonsmokers, 19 smokers. The cells incubated under various conditions including stimulation with 30 microM acid, 2 ionophore A23187, or both. Each experiment was performed parallel using a smoker nonsmoker....
Rainbow trout (Salmo gairdneri) and coho salmon (oncorhynchus kisutch) were exposed to aflatoxin B1 (AFB1) either by passive embryo uptake or dietary treatment after hatching feeding onset. Trout as embryos an aqueous solution of 0.5 p.p.m. AFB1 for 15 min showed a 62% tumor incidence 12 months later, whereas similar 30 only 9% incidence. The difference between response was even greater treatment. 4 weeks 20 p.p.b. had 40 failed develop tumors. A 5% observed in 3 exposure 5000 AFB1, lethal...
Pyrrolizidine alkaloids (PAs) are potent carcinogenic and anti-mitotic compounds produced by a large number of plant species. In this study, we investigated in vitro the DNA—protein cross-linking activity several structurally diverse PAs. The DNA cross-linked proteins induced PAs were also isolated characterized mammalian cells. At 300 500 μM, pyrrolic (dehydrosenecionine, dehydromonocrotaline, dehydroseneciphylline, dehydroriddelliine) cross-links. Protein-associated cross-links accounted...
In January 2004, the normally picturesque Cache Valley in northern Utah made national headlines with highest PM2.5 levels nation. Epidemiological studies linked exposure to particulate air pollution other locations stroke and Alzheimer's disease early mortality from all causes, cancer, cardiopulmonary diseases. To determine potential effects of these particles on human health, bronchial epithelial cells (BEAS-2B) were cultured collected various Valley. These slightly cytotoxic, but more...
Because of its presumed adverse health effects, particulate air pollution (PM) has received growing attention, but the cellular mechanisms by which PM exerts toxicity are not well elucidated. been associated with early mortality from illnesses that share endoplasmic reticulum (ER) stress as a mechanism pathogenesis. In this study, we examined whether would induce unfolded protein response (UPR) is to ER stress. Coarse (PM10) and fine (PM2.5) was collected single location in Northern Utah's...
Dietary exposure to aflatoxin B1 (AFB1) is detrimental avian health and leads major economic losses for the poultry industry. AFB1 especially hepatotoxic in domestic turkeys (Meleagris gallopavo), since these birds are unable detoxify by glutathione-conjugation. The impacts of on turkey hepatic transcriptome potential protection from pretreatment with a Lactobacillus-based probiotic mixture were investigated through RNA-sequencing. Animals divided into four treatment groups RNA was...
Journal Article Comparative mutagenicity of aflatoxins using a Salmonella /trout hepatic enzyme activation system Get access Roger A. Coulombe, Coulombe 1 Department Food Science and Technology, Oregon State UniversityCorvallis, OR 97331, USA Present address: Environmental Toxicology, University California, Davis, CA 95616, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar Dennis W. Shelton, Shelton Russell O. Sinnhuber, Sinnhuber Joseph E. Nixon...
The mycotoxin aflatoxin B 1 (AFB ) is a hepatocarcinogen in many animal models and probably human carcinogen. Besides being dietary carcinogen, AFB has been detected dusts generated the processing transportation of -contaminated products. Inhalation grain contaminated with may be risk factor lung cancer. Aflatoxin requires cytochrome P-450 (CYP)-mediated activation to form cytotoxic DNA-reactive intermediates, this liver mediated by CYP 1A2 3A4 isoforms. Which isoforms are important not well...