A5080658283- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Synthesis and Biological Evaluation
- Lung Cancer Treatments and Mutations
- Plant Parasitism and Resistance
- Plant Molecular Biology Research
- Plant and animal studies
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hepatitis C virus research
- Bone Tumor Diagnosis and Treatments
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Gut microbiota and health
- Cell Adhesion Molecules Research
- Calcium signaling and nucleotide metabolism
- interferon and immune responses
- Adenosine and Purinergic Signaling
- Radiation Therapy and Dosimetry
- Respiratory Support and Mechanisms
- Chemotherapy-induced cardiotoxicity and mitigation
- Fibromyalgia and Chronic Fatigue Syndrome Research
Indiana University – Purdue University Indianapolis
2019-2024
Indiana University School of Medicine
2019-2024
South China University of Technology
2024
Indiana University Health
2019-2024
Shanghai Chest Hospital
2023
Shanghai Jiao Tong University
2023
Indiana University
2023
University of Indianapolis
2022
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
2021
VIB-UGent Center for Plant Systems Biology
2015-2021
Strigolactones are important rhizosphere signals that act as phytohormones and have multiple functions, including modulation of lateral root (LR) development. Here, we show treatment with the strigolactone analog GR24 did not affect LR initiation, but negatively influenced priming emergence, latter especially near root–shoot junction. The cytokinin module ARABIDOPSIS HISTIDINE KINASE3 (AHK3)/ARABIDOPSIS RESPONSE REGULATOR1 (ARR1)/ARR12 was found to interact GR24-dependent reduction in...
Abstract Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple types and has emerged as a promising target for direct tumor-killing. Here, we demonstrate that NQO1-targeting prodrug β-lapachone triggers tumor-selective leading to cell-dependent control. β-Lapachone catalyzed bioactivated by NQO1 generate ROS high cells triggering oxidative stress release the damage signals...
Abstract Background With cancer-associated fibroblasts (CAFs) as the main cell type, rich myxoid stromal components in chordoma tissues may likely contribute to its development and progression. Methods Single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, bulk RNA-seq, multiplexed quantitative immunofluorescence (QIF) were used dissect heterogeneity, distribution, clinical implication of CAFs chordoma. Results We sequenced here 72 097 single cells from 3 primary recurrent tumor...
NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in most solid cancers, emerging as a promising target for tumor-selective killing. β-Lapachone (β-Lap), an NQO1 bioactivatable drug, exhibits significant antitumor effects on NQO1-positive cancer cells by inducing immunogenic cell death (ICD) and enhancing tumor immunogenicity. However, the interaction between β-Lap-mediated immune responses neutrophils, novel antigen-presenting (APCs), remains unknown. This study demonstrates that...
Currently, the oncogenic mechanism of endoplasmic reticulum stress-CAF (ERS-CAF) subpopulation in chordoma remains unknown. Here, single-cell RNA sequencing, spatial transcriptomics, GeoMx Digital Spatial Profiler, data-independent acquisition proteomics, bulk RNA-seq, and multiplexed quantitative immunofluorescence are used to unveil precise molecular how ERS-CAF affected progression. Results show that hypoxic microenvironment reprograms CAFs into subtype. Mechanistically, this occurrs via...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death globally. Currently there a lack tumor-selective and efficacious therapies for hepatocellular carcinoma. β-Lapachone (ARQ761 in clinical form) selectively kill NADPH: quinone oxidoreductase 1 (NQO1)-overexpressing cancer cells. However, effect on HCC virtually unknown. In this study, we found that relatively high NQO1 low catalase levels were observed both specimens collected from patients tumors TCGA...
Background: Type 2 diabetes mellitus (T2DM) and spinal degenerative disorders (SDD) are common diseases that frequently coexist. However, both traditional observational studies recent Mendelian randomization (MR) have demonstrated conflicting evidence on the association between T2DM SDD. This comparative study explored compared SDD using MR analyses. Methods: For analyses, cross-sectional (44,972 participants with 403,095 without T2DM), case-control (38,234 409,833 SDD), prospective (35,550...
This study sought to identify molecular subtypes of breast cancer (BC) and develop a stem cells (BCSCs)-related gene risk score for predicting prognosis assessing the potential immunotherapy. Unsupervised clustering based on prognostic BCSC genes was used determine BC subtypes. Core identified by non-negative matrix factorization algorithm (NMF) were screened using weighted co-expression network analysis (WGCNA). A model constructed machine learning as well LASSO regression multivariate Cox...
Pancreatic cancer is among the top five leading causes of cancer-related deaths worldwide, with poor overall survival rates. Current therapies for pancreatic lack tumor specificity, resulting in harmful effects on normal tissues. Therefore, developing tumor-specific agents treatment critical. NAD(P)H:quinone oxidoreductase 1 (NQO1), highly expressed cancers but not associated tissues, makes NQO1 bioactivatable drugs a potential therapy selectively killing
Abstract The synthetic strigolactone (SL) analog, rac-GR24, has been instrumental in studying the role of SLs as well karrikins because it activates receptors DWARF14 (D14) and KARRIKIN INSENSITIVE 2 (KAI2) their signaling pathways, respectively. Treatment with rac-GR24 modifies root architecture at different levels, such decreasing lateral density (LRD), while promoting hair elongation or flavonol accumulation. Previously, we have shown that biosynthesis is transcriptionally activated by...
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have exhibited great promise in the treatment of tumors with homologous recombination (HR) deficiency, however, PARPi resistance, which ultimately recovers DNA repair and cell progress, has become an enormous clinical challenge. Recently, KP372-1 was identified as a novel potential anticancer agent that targeted redox enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), to induce extensive reactive oxygen species (ROS) generation amplified...
Objective. To analyze the expression of miR-127 in serum patients with acute respiratory distress syndrome (ARDS) and to explore its correlation severity ARDS value as a molecular marker for diagnosis ARDS. Methods. 70 admitted our hospital from September 2017 2019 were selected observation group, 60 healthy persons physical examination collected control group. RT-PCR was used detect levels all subjects, group compared. The oxygenation index (PaO2/FiO2) recorded divided into three subgroups:...
Lung and breast cancers rank as two of the most common lethal tumors, accounting for a substantial number cancer-related deaths worldwide. While past decades have witnessed promising progress in tumor therapy, developing targeted therapies continues to pose significant challenge. NAD(P)H quinone oxidoreductase 1 (NQO1), two-electron reductase, has been reported therapeutic target across various solid tumors. β-Lapachone (β-Lap) deoxynyboquinone (DNQ) are NQO1 bioactivatable drugs that...
Abstract Aim The aim of this study was to clarify the alterations angiopoietin‐related growth factor ( AGF , also known as A ngptl6/ ARP 5) in serum normally pregnant women and pre‐eclamptic explore role pre‐eclampsia. Material Methods Thirty healthy non‐pregnant women, 118 (30 at 6–12 gestational weeks, 30 13–28 weeks 58 29–40 respectively) 46 were recruited. Fasting blood samples obtained from all subjects. Fifteen provided their 24 48 h after cesarean section, respectively. Enzyme‐linked...
β-Lapachone is a classical quinone-containing anti-tumor NQO1 bioactivatable drug which directly kills overexpressing cancer cells. However, the clinical applications of β-lapachone are major limited by its high toxicity and modest lethality. To overcome this side effect expand therapeutic utility β-lapachone, we here demonstrate novel combination therapy with proliferating cell nuclear antigen (PCNA) inhibitor T2 amino alcohol (T2AA) in various NQO1+ PCNA has DNA clamp processivity...
Objective: The association between Type 2 diabetes mellitus (T2DM) and risk of spinal degenerative disorders (SDD) remains controversial. Here, we sought to explore the causal effects T2DM on SDD or its subtypes using two-sample Mendelian Randomization (MR) approach.Methods: We first investigated susceptibility based a cross-sectional study UK Biobank data. Then, determined role in logistic regression model. Finally, prospective with follow-up information available, evaluated whether was...