A5065308648- Marine Toxins and Detection Methods
- Nicotinic Acetylcholine Receptors Study
- Animal Ecology and Behavior Studies
- Environmental Toxicology and Ecotoxicology
- Marine Sponges and Natural Products
- Environmental Chemistry and Analysis
- Marine Biology and Environmental Chemistry
- Chemical synthesis and alkaloids
- Synthetic Organic Chemistry Methods
- Forensic Toxicology and Drug Analysis
- Marine and coastal ecosystems
- Neuroscience of respiration and sleep
- Radioactive element chemistry and processing
- Neuroscience and Neuropharmacology Research
- Municipal Solid Waste Management
- Inorganic and Organometallic Chemistry
- Archaeology and ancient environmental studies
- Paraquat toxicity studies and treatments
- Isotope Analysis in Ecology
- Molecular Sensors and Ion Detection
- Wastewater Treatment and Reuse
- Metallurgy and Cultural Artifacts
- Mass Spectrometry Techniques and Applications
- Cultural Heritage Materials Analysis
- Alcohol Consumption and Health Effects
Norwegian University of Life Sciences
2004-2019
Canadian Food Inspection Agency
2011
Institute for Marine Biosciences
2005-2006
Health Research Council of New Zealand
2004
University of Waikato
2004
AgResearch
2004
University of Oslo
2002
Norwegian Defence Research Establishment
1969
A method that uses liquid chromatography with tandem mass spectrometry (LC/MS/MS) has been developed for the highly sensitive and specific determination of amnesic shellfish poisoning toxins, diarrhetic other lipophilic algal toxins metabolites in shellfish. The was subjected to a full single-laboratory validation limited interlaboratory study. Tissue homogenates are blended methanol-water (9 + 1), centrifuged extract is cleaned up hexane wash. LC/MS/MS (triple quadrupole) used quantitative...
Sixteen laboratories participated in a collaborative study to evaluate method performance parameters of liquid chromatographic analysis for paralytic shellfish toxins (PST) blue mussels (Mytilus edulis), soft shell clams (Mya arenaria), sea scallops (Placopectin magellanicus), and American oysters (Crassostrea virginicus). The specific analogs tested included saxitoxin, neosaxitoxin, gonyautoxins-1 -5, decarbamoyl-gonyautoxins-2 -3, decarbamoyl-saxitoxin, N-sulfocarbamoyl-gonyautoxin-2 -3....
Mussels sampled in the spring of 2002 and 2003 from Skjer, a location Sognefjord, Norway, tested positive mouse bioassay for lipophilic toxins. The symptoms, which included cramps, jumping, short survival times (as low as 4 min), were not characteristic toxins previously observed Norway. A survey algae present at aquaculture sites showed that toxicity correlated with blooms Alexandrium ostenfeldii. Up to 2200 cells/L found peak one bloom. In Canadian waters, this alga is known be producer...
Abstract Cultured mussels sampled in the spring of 2002 and 2003 from Skjer, a location Sognefjord, Norway, tested positive mouse bioassay for lipophilic toxins. In previous report, it was established that number spirolides, cyclic imine toxins produced by phytoplankton Alexandrium ostenfeldii , were present responsible observed toxicity. The main toxin proved to be new compound named 20‐methyl spirolide G. subsequent studies, delayed onset spirolide‐like symptoms exceeding usual time limit...
The aim of this study was to analyze a variety environmental organic contaminants emerging concern (CEC) and their metabolites in representative digestate samples from Norwegian biogas production plants. Biogas digestates can be valuable source for soil amendments and/or fertilizers commercial agriculture. It is important assess whether the contain harmful order avoid unintended exposure human consumers. In total 19 12 plants Norway were collected analyzed. Furthermore, process related...
41a-Homoyessotoxin (1), a new analogue of yessotoxin (7), was isolated from extracts Protoceratium reticulatum grown in culture. In addition, 9-methyl-41a-homoyessotoxin (2) and nor-ring A-yessotoxin (3) were identified as the major components mixed fraction. The structural information initially obtained LC-UV LC-MS3 chromatograms, with subsequent definitive structure determination by NMR, LC-MS/MS, high-resolution MS. Full 1H indirectly detected 13C NMR assignments for all but two carbon...
This study describes the development of Response Surface Pathway (RSP) design, assesses its performance and effectiveness in estimating LD50, compares RSP with Up Down Procedures (UDPs) Random Walk (RW) design.
During the summer of 2002 there were several episodes human intoxication after consumption brown crabs ( Cancer pagurus ) caught along Norwegian south coast. The toxic agent was one well-known phycotoxins, diarrhoetic shellfish poisoning (DSP) complex, routinely found in blue mussels Mytilus edulis ). This toxin has not previously been documented crabs. route and rate accumulation as well depuration determined laboratory experiments. DSP toxins only accumulate digestive organs...
SummaryN-ethyl maleimide (NEM) a known cellular radiosensitizer was studied from radiation chemical viewpoint. It found to react rapidly with water free radicals. The NEM-OH radical adduct can further another NEM molecule in the absence of oxygen. also reacts radicals produced by reactions OH and hydrated electrons nucleic acid components. These occur oxygen both electron transfer bond formation. is able compete for reaction + thymine. oxygen-like may explain part mode action as at level.