A5058551453- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Blood Coagulation and Thrombosis Mechanisms
- Inflammatory Bowel Disease
- Renal Transplantation Outcomes and Treatments
- Microscopic Colitis
- Enzyme function and inhibition
- Drug-Induced Adverse Reactions
- Cardiac Arrhythmias and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bone Metabolism and Diseases
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Bone health and treatments
- Rheumatoid Arthritis Research and Therapies
- HIV Research and Treatment
- Cardiac tumors and thrombi
- Atrial Fibrillation Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- COVID-19 Impact on Reproduction
- Advanced Glycation End Products research
- Complement system in diseases
- Dialysis and Renal Disease Management
Akdeniz University
2014-2024
Akdeniz University Hospital
2021-2023
Pediatrics and Genetics
2014
Karadeniz Technical University
2002-2013
The MTHFR C677T mutation has been shown to be associated with venous thrombosis. role of this in ischemic stroke is unclear. We investigated whether the a risk factor for patients Black Sea Turkish population or not. analyzed 30 (19 male, 11 female) [median age: 50 years (range: 28-78)] who had no known predisposition factors and 242 (182 60 healthy controls 42 18-65)]. Detection was performed by using commercially available allele-specific PCR-ELISA kits. Prevalence genotype 49.1% (CT,...
Impaired trace element metabolism may be involved in some of the metabolic dysfunctions, and contribute to development vascular complications diabetic patients. In order investigate relationships among diabetes mellitus, status, leukocyte activation complications, 55 type 2 patients (34 with 21 without complications) 50 non-diabetic control subjects were studied. The mean count (p<0.001), polymorphonuclear elastase erythrocyte malondialdehyde glycated haemoglobin (p<0.001) levels, copper/...
Studies on the biochemical and molecular mechanisms underlying obesity have shown that expression of some proteins was decreased with in rat adipose tissue. One these is carbonic anhydrase III (CA III) which constitutes 24% cytosolic protein content its function unclear. A freshly isolated cell culture model used to examine effect leptin insulin CA expression. It found while increased it suggests decrease observed tissue may be related hyperleptinemia.
Polycythemia vera (PV) is a clonal myeloproliferative disorder characterized by predominantly excessive erythrocyte production. During the course of disease, bleeding or thrombosis may be observed. In PV patients, influence antifibrinolytic activities on development thrombohemorrhagic complications remains to elucidated. present study, alterations in activity patients and effects treatments these were investigated. Newly diagnosed therapy-naive 22 included. Thrombomodulin (TM), plasmin-alpha...
Bone disease is one of the hallmarks multiple myeloma (MM). The role osteoprotegerin (OPG) in RANK/RANKL/OPG signaling system well defined bone disease. Polymorphisms TNFRSF11B gene encoding OPG have been studied various diseases. However, relationship between levels and development lesions regardless RANKL yet unknown. In this study, effects polymorphism on MM were investigated.C950T C1181G polymorphisms 52 patients (36 with 16 without lesions) another 20 control subjects using DNA...
The genetic defect of coagulation factor V, known as V Leiden, produces a resistance to degradation by activated protein C (APC) and increases the risk venous thrombosis. However, role Leiden in formation left ventricular (LV) thrombus has not been studied. We investigated whether is for LV patients with acute myocardial infarction (AMI).We have analyzed clinical, echocardiographic biochemical data 135 consecutive (aged 58 +/- 13 years; 31 women) first anterior AMI. Two-dimensional...
Within the last few years a number of thrombophilic mutations have been identified. Pre-symptomatic testing for these established genetic risk factors identifies individuals predisposed to disease and often allows select suitable prophylactic interventions in time. We investigated whether or not prothrombin G20210A allele, factor V Leiden G1691A, MTHFR C677T allele are left ventricular thrombus (LV) patients with myocardial infarction (AMI) not.We analysed clinical, echocardiographic...
The aim of this study was to investigate the presence anti-carbonic anhydrase (CA II) autoantibodies in patients with end-stage renal disease (ESRD) and relationships between autoantibody titers ghrelin, glucose, blood urea nitrogen (BUN) creatinine.Serum CA II titers, malondialdehyde (MDA), BUN, creatinine ghrelin levels were measured 45 ESRD healthy subjects.The group (0.170 ± 0.237) significantly higher than those control (0.079 0.032; p = 0.035). MDA also (p < 0.001). A weak positive...
Abstract Aim: The aim of this study was to investigate the associations between human leukocyte antigen (HLA)‐DRB1 alleles with genetic susceptibility rheumatoid arthritis (RA) and production antibodies against cyclic citrullinated peptide (anti‐CCP antibody) factor (RF) in Turkish RA patients. Methods: We studied 291 patients 253 controls. Genotyping performed by polymerase chain reaction sequence‐specific oligonucleotide probes hybridization method. Serum levels anti‐CCP antibody, IgM‐RF...
The purpose of this study was to determine the predictive and prognostic factors for COVID-19 infection its relationship with human leukocyte antigen (HLA) in kidney transplant recipients.
Chronic kidney disease (CKD) is a prominent public health concern, defined as functional and structural damage to the kidneys. This study aims investigate association between human leukocyte antigen (HLA) alleles individuals with CKD different etiological subgroups of diesease. Genomic DNA was obtained from peripheral blood samples 1,079 patients retrospective 1,111 healthy control individuals. HLA genotyping conducted using Luminex based low-resolution method. Allele frequency distributions...
The genetic defect of coagulation factor V, known as V Leiden, produces a resistance to degradation by activated protein C and increased venous thrombosis. However, the role Leiden in formation left atrial thrombus with nonrheumatic fibrillation has not been studied. We investigated whether is risk for patients fibrillation. analyzed clinical, echocardiographic, biochemical data 105 consecutive These were divided into two groups; group A (n = 37) B 68) without thrombus. study also included...