Self‐assembly is a ubiquitous process in biology where it plays numerous important roles and underlies the formation of wide variety complex biological structures. Over past two decades, materials scientists have aspired to exploit nature's assembly principles create artificial materials, with hierarchical structures tailored properties, for fabrication functional devices. Toward this goal, both synthetic building blocks been subject extensive research self‐assembly. In fact, molecular...

A potential solution for prosthetic heart valves is tissue-engineered valves. Tissue-engineered (TEHVs) are designed to replicate the complex properties found in natural tissues, such as stiffness, anisotropy, and composition organization of cells extracellular matrix (ECM). Electrospinning regarded a highly versatile innovative approach fabricating numerous fibrous designs. In this review, we discuss recent developments electrospun valve scaffolds, including scaffold materials, cell types,...

Deterioration of retina and death the retinal cells due to age, diabetes, or occlusion can cause degeneration which leads loss vision. In this study, it is aimed design a bilayered matrix mimic choroid Bruch's membrane tissue. As choroid, microchanneled network resembling fractal tree was fabricated by photolithography over photo-cross-linkable methacrylated hyaluronic acid hydrogel. Gelatin collagen immobilized into microchannels enhance adherence Human Umbilical Vein Endothelial Cells...

Abstract A chemical derivative of xanthan gum polysaccharide is investigated as a new artificial matrix for the encapsulation chondrocytic cells. Toward this goal, novel micro‐droplet generator developed to produce microcapsules. Microcapsules with an average diameter 500 µm, smooth surface, and homogeneous size distribution are obtained. ATDC5 cells encapsulated in carboxymethyl (CMX) microcapsules remain viable observed proliferate prolonged culture periods enhanced metabolic activity....

Abstract This study investigates the impact of surface modifications on additively manufactured CoCr and Ti6Al4V dental alloys, focusing properties. Thin film carbon (C) gold (Au) coatings, as well alkali‐heat treatment, were applied to high‐ low‐polished specimens. Scanning electron microscopy (SEM) showed that thin coatings retained underlying topography, while treatment induced distinct morphological changes. Energy‐dispersive x‐ray spectroscopy (EDS) analysis revealed C‐coating enriched...

AbstractIn the present paper, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanocapsules were prepared by a double emulsion-solvent evaporation procedure (w/o/w) for encapsulation of model enzymes (L-asparaginase, catalase, glucose oxidase) and bovine serum albumin. To increase efficiency activity encapsulated enzyme, numerous modifications made in compositions phases emulsion. For preparation low molecular weight PHBV, polymer was treated with sodium borohydride. A 14-fold decrease (from 297...

Hydrophobized polysaccharides have emerged as a promising strategy in the biomedical field due to versatility design functional structures through spontaneous self-assembly cell-friendly conditions. Based on this concept, xanthan, bacterial extracellular polysaccharide with potential encapsulating matrix, was conjugated hydrophobic palmitoyl groups obtain an amphiphilic system able form capsules by processes. The conjugation of xanthan performed at different xanthan/palmitoyl chloride ratios...

The ultrastructure of the bone provides a unique mechanical strength against compressive, torsional and tensional stresses. An elastin-like recombinamer (ELR) with nucleation sequence for hydroxyapatite was incorporated into films prepared from collagen – silk fibroin blend carrying microchannel patterns to stimulate anisotropic osteogenesis. SEM fluorescence microscopy showed alignment adipose-derived stem cells (ADSCs) human osteoblasts (HOBs) on ridges in grooves patterned...

The main functions of wound dressing biomaterials are to promote a moist environment in the while protecting area from mechanical injury and microbial contamination. Furthermore, scaffold used for skin tissue engineering must mimic epidermal dermal layers as well support growth keratinocytes fibroblasts. In this study, PLLA (shell) EGF-encapsulated collagen (core) nanofibers were produced by coaxial electrospinning at 25 kV potential, 12 cm collector distance, 0.125 mL/h flow rate (15%)...

We report a mild cell encapsulation method based on self-assembly and microfluidics technology. Xanthan gum, an anionic polysaccharide, was used to trigger the of positively charged multidomain peptide. The resulted in formation nanofibrous matrix using microfluidic device, microcapsules with homogeneous size were fabricated. properties performance xanthan-peptide optimized by changing peptide/polysaccharide ratio their effects microcapsule permeability mechanical stability analyzed. effect...

Adipose derived stem cells (ADSCs) were cultured on collagen-silk fibroin films with microchannel and micropillar patterns to investigate the effects of cell morphology changes osteogenic differentiation. Channel pillar micropatterned prepared from collagen type I silk fibroin. While higher ADSC proliferation profiles obtained blend film, films, however, caused twice aspect ratio effective orientation cells. Alkaline phosphatase activity ADSCs was several times surface when measured...