A5029573290- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Inflammatory Biomarkers in Disease Prognosis
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Colorectal Cancer Screening and Detection
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- FOXO transcription factor regulation
- COVID-19 and healthcare impacts
- Renal and related cancers
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Hormonal and reproductive studies
- Peptidase Inhibition and Analysis
- Gut microbiota and health
- PARP inhibition in cancer therapy
Medical University of Warsaw
2014-2024
Medical University of Lublin
2021
University of Warsaw
2018
Abstract Background and Purpose Non-muscle-invasive bladder cancer (NMIBC) constitutes a heterogeneous group of tumors with different prognoses. This population-based study aimed to report real-world cancer-specific survival (CSS) NMIBC create prognostic nomogram based on the identified risk factors. Methods The Surveillance, Epidemiology, End Results database was searched for patients diagnosed from 2004 2015, who underwent transurethral resection tumor. dataset divided into development...
We aimed to compare the predictive value of different inflammatory markers in renal cell carcinoma (RCC). Four hundred ninety-five patients treated with nephrectomy for primary localized or locally advanced RCC between 2010 and 2018 were included retrospective analysis. The median follow-up entire cohort was 48 months. Based on preoperative laboratory measurements, higher neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), systemic response index (SIRI), immune-inflammation (SII),...
Diminished overall survival rate of non-Hodgkin lymphoma (NHL) patients treated with a combination regimen rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) has been recently linked to recurrent somatic mutations activating FOXO1. Despite the clinical relevance this finding, molecular mechanism driving resistance R-CHOP therapy remains largely unknown. Herein, we investigated potential role FOXO1 in therapeutic efficacy only targeted included regimen. We found...
Indications for restaging transurethral resection of the bladder tumor (reTURBT) in patients with non-muscle-invasive cancer (NMIBC) remain controversial. This study was aimed at evaluation clinical value and safety reTURBT different indications.This is a retrospective analysis consecutive 141 who underwent TURBT followed by years 2011-2015 single department. Pathological results surgical complications were analyzed whole cohort stratified stage (Ta, T1, Tx (no muscle specimen)) grade...
To develop an easy-to-use side-specific tool for the prediction of prostate cancer extracapsular extension (ECE) using clinical, biopsy, and MRI parameters.Retrospective analysis patients who underwent radical prostatectomy preceded by staging multiparametric was performed. Multivariate logistic regression used to choose independent predictors ECE. Continuous variables were transformed categorical ones choosing threshold values spline knots or testing thresholds in previously described...
We aimed at characterization of the patients undergoing radical cystectomy (RC) using prognostic model (a modified pentafecta). In multicenter retrospective study, we enrolled 304 with bladder cancer (pTis-4N0-2M0) who underwent RC between 2015 and 2020 in experienced centers. The definition pentafecta was as follows: no Clavien-Dindo grade III-V complications 90 days long-term related to urinary diversion <12 months, negative surgical margins, ≥10 lymph nodes (LNs) resected, recurrence ≤12...
Clinical trials with SRC family kinases (SFKs) inhibitors used alone or in a combination anti-CD20 monoclonal antibodies (mAbs) are currently underway the treatment of B-cell tumors. However, molecular interactions between these therapeutics have not been studied so far. A transcriptional profiling tumor cells incubated SFKs revealed strong downregulation MS4A1 gene encoding CD20 antigen. In panel primary and established tumors we observed that strongly affect expression at level, leading to...
Introduction We aimed to examine the change in number and severity of visits emergency departments (EDs) subsequent admissions for urgent urologic conditions early stage coronavirus disease 2019 (COVID-19) pandemic Poland. Material methods evaluated data from 13 centers Poland compared EDs before after advent COVID-19 2020, escalating national restrictions. Furthermore, on types complaints, crucial laboratory parameters, post-admission procedures were analyzed. Results In total 1,696 2,187...
Men with urinary retention secondary to benign prostatic hyperplasia (BPH) are prone genitourinary infections. Physicians should be aware of the current antimicrobial susceptibility pattern in this population if empirical treatment is needed. The goal study was evaluate variations prevalence, composition and bacterial flora men indwelling catheters subjected surgery for BPH chosen time periods since 1994. Necessary changes therapy were also assessed.All patients admitted a single urological...
Transurethral resection of bladder tumour (TURBT) is one the most commonly performed urologic procedures. Because shortcomings conventional TURBT, en-bloc concept was created.To analyse influence technique on surgical and oncological outcomes TURBT with electric current.This non-randomized, prospective controlled multicentre study enrolled 427 consecutive patients undergoing by five experienced endourologists in academic institutions. Choice procedure at discretion surgeon. The vast majority...
Poland was initially less affected by the coronavirus disease 2019 (COVID-19) pandemic, however, severe restrictions, and health care restructuration have impacted all areas of medicine, including urology. Therefore, we aimed, via an online survey, to examine impact COVID-19 pandemic on Polish urologists urology residents.
The selection of candidates for the curative treatment PCa requires a careful assessment life expectancy. Recently, blood-count inflammatory markers have been introduced as prognosticators oncological and non-oncological outcomes in different settings. This retrospective, monocentric study included 421 patients treated with radical prostatectomy (RP) nonmetastatic aimed at determining utility preoperative SII (neutrophil count × platelet count/lymphocyte count) predicting survival after RP....
Abstract Purpose To identify the risk factors for 5-year cancer-specific (CSS) and overall survival (OS) to compare accuracy of logistic regression (LR) artificial neural network (ANN) in prediction outcomes T1 non-muscle-invasive bladder cancer. Methods This is a population-based analysis using Surveillance, Epidemiology, End Results database. Patients with cancer (BC) who underwent transurethral resection tumour (TURBT) between 2004 2015 were included analysis. The predictive abilities LR...
Our study aimed to develop a noninvasive model using combination of the set clinical data and uroflowmetry (UFL) differentiate between detrusor underactivity (DU) bladder outlet obstruction (BOO) in non-neurogenic male patients with lower urinary tract symptoms (LUTS).