A5003647171- Plant-derived Lignans Synthesis and Bioactivity
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and biological activity
- Sesquiterpenes and Asteraceae Studies
- Phytochemical compounds biological activities
- Synthetic Organic Chemistry Methods
- Synthesis and Biological Evaluation
- Plant biochemistry and biosynthesis
- Synthesis and Reactions of Organic Compounds
- Research on Leishmaniasis Studies
- Carbohydrate Chemistry and Synthesis
- Asymmetric Synthesis and Catalysis
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Phytochemistry and Bioactive Compounds
- Cancer therapeutics and mechanisms
- Magnolia and Illicium research
- Trypanosoma species research and implications
- Synthesis of Organic Compounds
- Organic Chemistry Cycloaddition Reactions
Universidad de Salamanca
2015-2024
Instituto de Investigación Biomédica de Salamanca
2015-2024
Universidade do Vale do Itajaí
2020-2024
Pontificia Universidad Católica de Valparaíso
2001-2015
Universidade de Sorocaba
2014
Universidad de Antioquia
2014
University of Valparaíso
1998-2010
Instituto Superior Técnico
1997-2006
University of Lisbon
2000-2006
Universidad de Panamá
2005
We confirmed the ability of triterpenoid betulin to protect against neurotoxicity caused by Bothrops jararacussu snake venom in vitro mouse isolated phrenic nerve-diaphragm (PND) preparations and examined its capability vivo protection using rat external popliteal/sciatic nerve-tibialis anterior (EPSTA) preparation. Venom complete, irreversible blockade PND (40 μ g/mL), but only partial (~30%) EPSTA (3.6 mg/kg, i.m.) after 120 min. In PND, preincubation with commercial bothropic antivenom...
A general method for the one-step regioselective synthesis of 1-alkyl- or 1-aryl-1H-indazoles from ortho-halogenated alkanoylphenones, benzophenones, and arylcarboxylic acids, via copper-catalyzed amination, was developed by using 0.2% mol CuO in presence K2CO3. The reaction involves amination followed intramolecular dehydration. Different functionalized alkyl aryl ketones, diaryl benzoic acid derivatives were efficiently coupled with several hydrazines. Ligands commonly employed as...
Several pinacol derivatives of podophyllotoxins bearing different side chains and functions at C-7 were synthesized through reductive cross-coupling podophyllotoxone several aldehydes ketones. While possessing a hydroxylated chain C-7, the compounds retained their respective hydroxyl group with either 7α (podo) or 7β (epipodo) configuration. Along pinacols, some alkylidene alkyl also prepared. Cytotoxicities against neoplastic cells followed by cell cycle arrest cellular microtubule...
We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription Tat function were tested stably transfected HIV-LTR protein. Six compounds displayed NF-κB inhibition, four resulted antagonists three them showed both activities. Three inhibited replication IC₅₀ values < 25 µM. The antiviral effect 4-hydroxycoumarin...
The effect of four sub-extracts prepared from the lyophilized hydroalcoholic bark Dipteryx alata (Leguminosae-Papilionoideae) dissolved in a methanol-water (80:20) mixture through liquid-liquid partition procedure has been investigated against neuromuscular blockade venom snake Bothrops jararacussu. active CH2Cl2 sub-extract extensively analyzed for its chemical constituents, resulting isolation lupane-type triterpenoids: lupeol (1), lupenone (2), 28-hydroxylup-20(29)-en-3-one (3), betulin...
The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use a T-cell-mediated immune response. Of compounds tested, 4'-demethyldeoxypodophyllotoxin (8), β-apopicropodophyllin (6), isoxazoline-fused cyclolignan 15 are most potent with respect to their suppression activated splenocytes.
Bioassay-guided fractionation of the chloroform and ethanol extracts Tovomita longifolia leaves using cytotoxic antimicrobial assays resulted in isolation four new benzophenones, (E)-3-(2-hydroxy-7-methyl-3-methyleneoct-6-enyl)-2,4,6-trihydroxybenzophenone (1), (E)-3-(6-hydroxy-3,7-dimethylocta-2,7-dienyl)-2,4,6-trihydroxybenzophenone (2), 8-benzoyl-2-(4-methylpenten-3-yl)chromane-3,5,7-triol (3), 5-benzoyl-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene-6,8-diol (4), two known...
Certain members of the genus Eugenia are used as foods. One these species is umbelliflora, which for its fruits. The aim study was to isolate constituents CH2Cl2 fraction obtained from E. umbelliflora O. Berg (Myrtaceae) and also evaluate antimicrobial properties. Two new meroterpenoids, eugenial C (3) D (4) were isolated unripe fruits their structures established mainly by extensive NMR spectroscopy. In previous studies, extract showed significant antibacterial activity, can be attributed...
Quinones are secondary metabolites of higher plants associated with many biological activities, including antiviral effects and cytotoxicity. In this study, the anti-herpetic anti-dengue evaluation 27 terpenyl-1,4-naphthoquinone (NQ), 1,4-anthraquinone (AQ) heterocycle-fused quinone (HetQ) derivatives was done in vitro against Human Herpesvirus (HHV) type 1 2, Dengue virus serotype 2 (DENV-2). The cytotoxicity on HeLa Jurkat tumor cell lines also tested. Using plaque forming unit assays,...
Abstract 28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P‐388 murine leukemia, A‐549 human lung carcinoma, HT‐29 colon while assays performed on herpes simplex virus type I infecting fibroblasts monkey kidney (HSV/CV‐1) vesicular stomatitis hamster (VSV/BHK). A number substances active in both groups at concentrations below 1μM; deoxypodophyllotoxin ( 1 ) being the...
Nineteen cyclolignans of varied structures, most them isolated from Juniperus sabina leaves, were evaluated for their antineoplastic and anti-viral activities. They subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, HT-29 colon while the antiviral assays performed on herpes simplex virus type 1 infecting fibroblasts monkey kidney (HSV-1/CV-1) vesicular stomatitis hamster (VSV/BHK). A number substances active in both types at concentrations below µg/ml;...