Forty-seven plant extracts of 10 species the genus Euphorbia (Euphorbiaceae) used by Colombian traditional healers for treatment ulcers, cancers, tumors, warts, and other diseases, were tested in vitro their potential antitumour (antiproliferative cytotoxic) antiherpetic activity. To evaluate capacity to inhibit lytic activity herpes simplex virus type 2 (HSV-2) reduction viability infected or uninfected cell cultures, end-point titration technique (EPTT) MTT...

Two essential oils of Lippia alba (Mill.) N.E. Brown (Verbenacea), the carvone and citral chemotypes 15 their compounds were evaluated to determine cytotoxicity antifungal activity. Cytotoxicity assays for both carried out with tetrazolium-dye, which showed a dose-dependent cytotoxic effect against HeLa cells. Interestingly, this on cells (HeLa non-tumoural cell line, Vero) was lower than that commercial alone. Commercial highest activity The Candida parapsilosis, krusei, Aspergillus flavus...

Extracts of nine species plants traditionally used in Colombia for the treatment a variety diseases were tested vitro their potential antitumor (cytotoxicity) and antiherpetic activity. MTT (Tetrazolium blue) Neutral Red colorimetric assays to evaluate reduction viability cell cultures presence absence extracts. was also effects extracts on lytic activity herpes simplex virus type 2 (HSV-2). The 50% cytotoxic concentration (CC50) inhibitory viral effect (EC50) each extract calculated by...

Colombian flora includes plant families such as Labiatae and Verbenaceae which are employed for treatment of several diseases. In this study, the chemical compositions essential oils belonging to were determined by GC-MS GC-FID, respectively. The antiviral activity forty these plants some monoterpenes evaluated on Human Herpes Viruses types 1 2 using end-point titration technique (EPTT). Furthermore, with higher reported in screening used evaluate inhibitory effect pre-infective stages. most...

Quinones are secondary metabolites of higher plants associated with many biological activities, including antiviral effects and cytotoxicity. In this study, the anti-herpetic anti-dengue evaluation 27 terpenyl-1,4-naphthoquinone (NQ), 1,4-anthraquinone (AQ) heterocycle-fused quinone (HetQ) derivatives was done in vitro against Human Herpesvirus (HHV) type 1 2, Dengue virus serotype 2 (DENV-2). The cytotoxicity on HeLa Jurkat tumor cell lines also tested. Using plaque forming unit assays,...

Thirty-six essential oils from Verbenaceae and Asteraceae family plants along with their major constituents were evaluated to determine cytotoxicity on Jurkat, HeLa, HepG2 Vero cell lines. The collected in different regions of Colombia, extracted through microwave-assisted hydrodistillation then characterized GC/MS GC/FID analyses. Cytotoxic activity testing was carried out using a tetrazolium-dye (MTT) assay. Lippia alba Citral Carvone chemotypes showed the lowest IC50 selectivity index...

A series of C14-hydroxy derivatives dehydroabietic acid were synthesised from commercial abietic and evaluated for their cytotoxic, antimycotic, antiviral activities. From these derivatives, triptoquinone C-4 epimers obtained immunomodulatory activity was additionally evaluated. None the tested compounds showed against herpes simplex virus type 1 (HHV-1), nor did they display antimycotic certain Aspergillus, spp. except one compound, abieta-8,11,13-trien-14,18-diol. Interestingly, two...

New 1,4-anthracenediones bearing fused-heterocycle rings were synthesized and evaluated as cytotoxics, antifungals antivirals. Some of them showed GI₅₀ at the μM level.

Interest in medicinal and aromatic plants as a source of antimicrobial drugs has emerged, mainly due to increased resistance infectious agents. In this study, the antifungal cytotoxic activity thirteen essential oils nine extracts genus Piper, from Colombia, were evaluated. The Piper hispidum Sw oil showed against multi-resistant fungus Fusarium oxysporum. Six samples strong dermatophytes, being bogotense most active, followed by P. hispidum. hispidum, coruscans, marginatum cf. divaricatum,...

A series of synthetic spongiane-type diterpenes have been tested in vitro for their potential antitumor and antiherpetic activity. Although the antiviral activity these compounds against herpes simplex virus type 2 (HSV-2) was very weak, some exhibited relevant cytotoxicity human tumor cell lines HeLa HEp-2. The biological formyl spongianes is reported first time. With present study, structure−activity trends are suggested cytotoxic sponge-derived natural products.

Dengue virus (DENV) infection is the most arbovirosis in world. However, medications have not been approved for its treatment. Drug discovery based on host-targeted antiviral (HTA) constitutes a new promising strategy, considering their high genetic barrier to resistance and low probability of selecting drug strains. In this study, we tested fifty-seven podophyllotoxin-related cyclolignans DENV-2 infected cells found compound was S.71. Using cellular molecular biology experiments, discovered...

Fourteen semisynthetic compounds derived from the natural scopadulane-type diterpenes thyrsiflorin A (4), B (5), and C (6), including several precursors, have been examined in vitro for their antiherpetic activity against Herpes simplex virus type II (HSV-2) cytotoxicity two human tumor cell lines. Four of these showed moderate activity, but none them exhibited a significant lines used. Some structure−activity relationships identified antiviral scopadulane derivatives as well important...

Abstract The essential oils from Lippia alba (Miller) N.E Brown (Verbenaceae Family) collected in different regions of Colombia were obtained by microwave-assisted hydrodistillation. Their chemical compositions determined GC and GC/MS. Two chemotypes distinguished, characterized carvone citral as main constituents. Antifungal activity the was following standard microdilution protocols AFST-EUCAST for C. krusei parasilopsis, CLSI-M38A Aspergillus fumigatus A. flavus. both L. showed antifungal...