A5000158966- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Advancements in Battery Materials
- Carbon and Quantum Dots Applications
- Supercapacitor Materials and Fabrication
- Nanocluster Synthesis and Applications
- Luminescence and Fluorescent Materials
- Sulfur-Based Synthesis Techniques
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Reactions
- Quantum Dots Synthesis And Properties
- Biosensors and Analytical Detection
- Electrochemical Analysis and Applications
- RNA Interference and Gene Delivery
- Fuel Cells and Related Materials
- Synthetic Organic Chemistry Methods
- MXene and MAX Phase Materials
- Electrocatalysts for Energy Conversion
- Graphene and Nanomaterials Applications
- Advanced Battery Materials and Technologies
- Perovskite Materials and Applications
- Organometallic Complex Synthesis and Catalysis
- Advanced Battery Technologies Research
- Electrochemical sensors and biosensors
Jiangsu University of Science and Technology
2019-2025
Nanjing University
2015-2024
Zhejiang International Studies University
2023
Zhanjiang Experimental Station
2019-2021
State Key Laboratory of Analytical Chemistry for Life Science
2015
Weatherford College
2013
Peking University
2013
Hangzhou Normal University
2010-2013
Anhui Normal University
2012
Great challenges in investigating the release of drug complex cellular microenvironments necessitate development stimuli-responsive delivery systems with real-time monitoring capability. In this work, a smart nanocarrier based on fluorescence resonance energy transfer (FRET) is fabricated by capping graphene quantum dots (GQDs, acceptor) onto fluorescent mesoporous silica nanoparticles (FMSNs, donor) via ATP aptamer for ATP-triggered release. Under extracellular conditions, FMSNs remains...
Abstract Metal‐organic frameworks (MOFs) have attracted considerable attention as promising next‐generation active electrode materials for lithium‐ion batteries (LIBs) or sodium‐ion (SIBs) because of ultrahigh specific surface area, uniformly distributed pores, and tunable structure. However, there are some disadvantages inevitably far from meeting commercial requirements, such low conductivity, inconvenient electron transmission, unsatisfactory circulation stability. In this review, a...
DNAzyme-based fluorescent probes for imaging metal ions in living cells have received much attention recently. However, employing situ within subcellular organelles, such as nucleus, remains a significant challenge. We developed three-stranded DNAzyme probe (TSDP) that contained 20-base-pair (20-bp) recognition site of CRISPR/Cas9, which blocks the activity. When Cas9, with its specialized nuclear localization function, forms an active complex sgRNA cell it cleaves TSDP at site, resulting...
Halide perovskite materials have emerged as a new class of revolutionary photovoltaic and optoelectronic nanomaterials. However, the study on electrochemiluminescence (ECL) from halide nanomaterials is still in its infancy due to their instability, sensitivity, difficulties purification film formation. Here, we propose scraping coating method for fabrication high-quality quantum dot (QD) electrode, which shows dense uniform packing with minimum grain size. When CsPbBr3 QDs are taken model...
Abstract Monitoring drug release in vitro and vivo is of paramount importance to accurately locate diseased tissues, avoid inappropriate dosage, improve therapeutic efficiency. In this regard, it promising develop strategies for real-time monitoring inside targeted cells or even living bodies. Thus far, many multi-functional delivery systems constructed by a variety building blocks, such as organic molecules, polymeric nanoparticles, micelles, inorganic have been developed monitoring....
A simple and effective fluorescence method for the detection of TNT has been developed based on recognition amine-capped silicon quantum dots (SiQDs) to TNT.
In vivo monitoring of cargo protein delivery is critical for understanding the pharmacological efficacies and mechanisms during cancer therapy, but it still remains a formidable challenge because difficulty in observing nonfluorescent proteins at high resolution sensitivity. Here we report an outer-frame-degradable nanovehicle featuring near-infrared (NIR) dual luminescence real-time tracking vivo. Upconversion nanoparticles (UCNPs) fluorophore-doped degradable macroporous silica (DS) with...
Fluorescent silicon nanodots have shown great prospects for bioimaging and biosensing applications. Although various fluorescent silicon-containing (SiNDs) been developed, there are few reports about renal-clearable multicolor SiNDs. Herein, SiNDs synthesized by using silane molecules organic dyes through a facile one-step hydrothermal method. The fluorescence of the resulting can be tuned to blue (bSiNDs), green (gSiNDs), red (rSiNDs) simply changing categories reagents or dye molecules....
Developing a comprehensive strategy for imaging various biomarkers (
Abstract DNAzyme‐based fluorescent probes for imaging metal ions in living cells have received much attention recently. However, employing situ within subcellular organelles, such as nucleus, remains a significant challenge. We developed three‐stranded DNAzyme probe (TSDP) that contained 20‐base‐pair (20‐bp) recognition site of CRISPR/Cas9, which blocks the activity. When Cas9, with its specialized nuclear localization function, forms an active complex sgRNA cell it cleaves TSDP at site,...
Early diagnosis of tumors allows effective treatment primary cancers through localized therapeutic interventions. However, developing diagnostic tools for sensitive, simple, and early tumor (especially less than 2 mm in diameter) detection remains a challenge. Herein, we presented biomarker-activatable nanoprobe that enabled near-infrared (NIR) photothermally amplified signal fluorescence imaging urinalysis tumor. This activatable was constructed by encapsulating renal-clearable NIR ZW800...
AuNCs@MnO<sub>2</sub> core–shell nanoprobes for NIR fluorescence imaging of intracellular GSH based on the absorption competition mechanism.
Abstract Multimodal cancer therapies show great promise in synergistically enhancing anticancer efficacy through different mechanisms. However, most current multimodal either rely on complex assemblies of multiple functional nanomaterials and drug molecules or involve the use nanomedicines with poor vivo degradability/metabolizability, thus restricting their clinical translatability. Herein, a nanoflower‐medicine using iron ions, thioguanine (TG), tetracarboxylic porphyrin (TCPP) are...
Peroxidase-like two-dimensional DNA/Fe<sub>3</sub>O<sub>4</sub> networks were constructed by the hybridization chain reaction and applied to detect microRNA down aM level.
Protein kinases constitute a rich pool of biomarkers and therapeutic targets tremendous diseases including cancer. However, sensing kinase activity in vivo while implementing treatments according to hyperactivation remains challenging. Herein, we present nanomediator-effector cascade system that can situ magnify the subtle events kinase-catalyzed phosphorylation via DNA amplification machinery achieve imaging kinase-responsive drug release vivo. In this cascade, phosphorylation-mediated...
Combining targeting ability, imaging function, and photothermal/photodynamic therapy into a single agent is highly desired for cancer theranostics. Herein, we developed one-for-all nanoplatform with N/P/S-codoped fluorescent carbon nanodots (CNDs) tumor-specific phototheranostics. The CNDs were prepared via one-pot hydrothermal process using cells as sources of carbon, nitrogen, phosphorus, sulfur. obtained exhibit wide light absorption in the range 200–900 nm excitation-dependent emission...
Abstract A one‐pot synthesis of alkynyl sulfide from terminal alkyne has been reported via lithiation the alkyne, oxidative addition sulfur, consecutively followed by nucleophilic substitution lithium thiolate to various halides. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 23:105–110, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20745
Herein, we designed a peptide chain with special sequence and constructed novel label-free fluorescent turn-on biosensor for the assay of trypsin based on interaction between quantum dots. Using this sensor, can be detected sensitively detection limit 20 ng mL−1, even by naked eye under UV lamp.
The polyaniline (PAN)-coated CdSeTe quantum dots (QDs) were prepared by in situ polymerization of aniline on the surface QDs. PAN-coated QDs has a tremendously enhanced fluorescence (∼40 times) and improved biocompatibility compared to uncoated intensity can be adjusted controlling construction parameters PAN shell. kinetics controllable process was studied varying temperature, apparent activation energy estimated. With same method, series derivatives also tested coat this study. All showed...