A5100670611- Genetics, Aging, and Longevity in Model Organisms
- BIM and Construction Integration
- Sirtuins and Resveratrol in Medicine
- Fault Detection and Control Systems
- Machine Fault Diagnosis Techniques
- Adipose Tissue and Metabolism
- Prosthetics and Rehabilitation Robotics
- Muscle activation and electromyography studies
- Mineral Processing and Grinding
- COVID-19 Clinical Research Studies
- Advanced Algorithms and Applications
- Physics of Superconductivity and Magnetism
- Action Observation and Synchronization
- Primate Behavior and Ecology
- Resource-Constrained Project Scheduling
- 3D Modeling in Geospatial Applications
- Robot Manipulation and Learning
- SARS-CoV-2 and COVID-19 Research
- Magnetic confinement fusion research
- AI-based Problem Solving and Planning
- Manufacturing Process and Optimization
- Simulation Techniques and Applications
- Mitochondrial Function and Pathology
- Grey System Theory Applications
- Advanced Data Processing Techniques
Beijing Proteome Research Center
2024
Huazhong University of Science and Technology
2011-2023
Institute of Electrical and Electronics Engineers
2022-2023
University of Memphis
2022-2023
Antea Group (France)
2023
Engineering Systems (United States)
2022-2023
Beihang University
2010-2023
Chongqing University of Posts and Telecommunications
2023
Capital Medical University
2015-2022
China Rehabilitation Research Center
2022
Calorie restriction increases life span in many organisms, including the budding yeast Saccharomyces cerevisiae . From a large-scale analysis of 564 single-gene–deletion strains yeast, we identified 10 gene deletions that increase replicative span. Six these correspond to genes encoding components nutrient-responsive TOR and Sch9 pathways. tor1 D or sch9 cells failed further and, like calorie restriction, deletion either SCH9 TOR1 increased independent Sir2 histone deacetylase. We propose...
Studies in invertebrate model organisms have been a driving force aging research, leading to the identification of many genes that influence life span. Few these examined context mammalian aging, however, and it remains an open question as whether what extent pathways modulate longevity are conserved across different eukaryotic species. Using comparative functional genomics approach, we performed first quantitative analysis degree which between two highly divergent species, yeast...
A model for replicative life span extension by calorie restriction (CR) in yeast has been proposed whereby reduced glucose the growth medium leads to activation of NAD+-dependent histone deacetylase Sir2. One mechanism this putative Sir2 is that CR enhances rate respiration, turn leading altered levels NAD+ or NADH, and ultimately resulting enhanced activity. An alternative which decreases inhibitor nicotinamide through increased expression gene coding nicotinamidase, PNC1. We have...
Two models have been proposed for how calorie restriction (CR) enhances replicative longevity in yeast: (i) suppression of rDNA recombination through activation the sirtuin protein deacetylase Sir2 or (ii) decreased activity nutrient-responsive kinases Sch9 and TOR. We report here that CR increases lifespan independently all Sir2-family proteins yeast. Furthermore, we demonstrate nicotinamide, an inhibitor Sir2-mediated deacetylation, interferes with extension from CR, but does so...
Anomaly detection is a common technology for condition monitoring that important safe and reliable production in industry. In this work, we proposed an anomaly method rotating machinery based on vibration vectors,whichwas inspiredby Polar plot analysis. The vector, consisting of amplitude phase, was selected as monitored indicator at different characteristic frequencies (CFs). original vectors obtained by fast Fourier transform-based order analysis (FFT-OA) were mapped from to Cartesian...
Abstract Background Walking and running are the most common means of locomotion in human daily life. People have made advances developing separate exoskeletons to reduce metabolic rate walking or running. However, combined requirements overcoming fundamental biomechanical differences between two gaits minimizing penalty exoskeleton mass make it challenging develop an that can energy during both gaits. Here we show be reduced by regulating hip flexion consumption period using unpowered...
The hand structure possesses a greater potential for performing manipulative skills than is typically observed, whether in humans or non-human anthropoids. However, precise assessment of the hands has been challenging, which hampers our understanding evolution abilities anthropoid hands. Here, we establish functional model to quantitatively infer potentials based on proportions. Our results reveal large disparity among From aspect proportions, human best species with closer that are not...
The generation of well-defined and moderately sized field installation work packages for the construction workforce, referred to as workface planning, has been recently employed plan large-scale industrial projects under tight schedules. However, traditional CPM-based scheduling several thousand (e.g. 5000 activities multiply by 10 per activity on average) is a tedious, error prone process. Defining proper logics controlling congestion among crossing areas, also effective resource allocation...
The process of planning and scheduling industrial construction fabrication (ICF) jobs is difficult because the sequence operations varies considerably from one product to another due unique design configuration products. Traditional critical path method (CPM)–related approaches are not effective CPM's limitation or inability model repetition operations, interactions between resources, what-if scenarios. Discrete event simulation (DES) often used processes that repetitive in nature; however,...
Under the trend of increasing installed capacity wind power, intelligent fault diagnosis turbine is great significance to safe and efficient operation farms. Based on knowledge turbines, this paper builds expert system diagnostic base by using confidence production rules self-learning method. In Visual Studio 2013 platform, C # language selected ADO.NET technology used access database. Development Fault Diagnosis Expert System for Wind Turbine. The purpose realize on-line through...
Over the course of both evolution and development, human musculoskeletal system has been well shaped for cushion function foot during foot-strike impulsive ankle joint push-off. Nevertheless, an efficient energy interaction between structure is still lacking in body itself, which may limit further potential economical walking. Here we showed metabolic expenditure walking can be lessened by unpowered exoskeleton robot that modulates among foot-ankle complex towards a more effective direction....
Discrete-event simulation (DES) has long been used as a management tool to analyze and study construction processes. Project scheduling is one of its useful applications in domain. By simulating the behavior production system over time, DES able reproduce process how jobs resources interact with each other. A schedule can then be viewed record this artificial history. However, simulation-based is, more often than not, limited create initial schedules. The problem update project based on...
Flow sensors inspired by the natural hair sensing mechanism have great prospect in research of micro-autonomous system and technology (MAST) for three-dimensional structure characteristics with high spatial quality utilization. A novel bio-inspired flow sensor (BHFS) based on resonant a unique asymmetric design is presented this paper. transducer signal detector which constituted two-stage micro-leverage two symmetrical resonators (double ended tuning fork, DETF) are adopted to realize...