A5085388511- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin D Research Studies
- Photoreceptor and optogenetics research
- Nitric Oxide and Endothelin Effects
- Peroxisome Proliferator-Activated Receptors
- Sodium Intake and Health
- Pregnancy and preeclampsia studies
- Mitochondrial Function and Pathology
- Acute Lymphoblastic Leukemia research
- Sexual Differentiation and Disorders
- Cardiovascular Disease and Adiposity
- Receptor Mechanisms and Signaling
- Hormonal and reproductive studies
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Metabolism and Genetic Disorders
- Prenatal Screening and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Inflammatory mediators and NSAID effects
- Muscle metabolism and nutrition
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
Tel Aviv University
1989-2017
Tel Aviv Sourasky Medical Center
2007-2017
Institute of Endocrinology
2012
Washington University in St. Louis
2007
Sheba Medical Center
1989
Peroxisome proliferator-activated receptor-alpha is widely distributed in the vasculature where it believed to exert pleiotropic antiatherogenic effects. Its role regulation of blood pressure still unresolved; however, some evidence suggests that may affect renin-angiotensin system. We investigated its angiotensin II-induced hypertension Tsukuba hypertensive mouse (THM). This a model and atherosclerosis because high II aldosterone levels as result transgenic expression entire human Making...
Pregnant ICR mice were injected daily with 30 mg cyclosporin (CS)/kg body weight on days 6–8 or 10–12 of gestation. In parallel, control administered saline injections the same gestational days. The sacrificed 12, 15, 17 19 number resorption sites counted, embryos and placentae carefully separated, weighed examined macro- microscopically, along various other maternal organs. It was found that CS/kg weight, when to pregnant in 3 successive injections, did not raise mortality rate....
To determine whether low-dose calcitriol attenuates atherosclerosis in apoE-null mice and, if so, through which predominant mechanism.Starting at the age of 6 weeks, received intraperitoneal injections either 0.25 ng/g body weight or vehicle, every other day for 8 weeks.Calcitriol treatment resulted 35% reduction aortic sinus, and a significant decrease blood pressure. These effects were possibly mediated by downregulation renin-angiotensin system (RAS), as there was 64% level renin mRNA....
Inhibition of endothelial nitric oxide synthase (eNOS) accelerates atherosclerosis in ApoE-null mice by impairing the balance between angiotensin II (AII) and NO. Our previous data suggested a role for PPAR α deleterious effect renin-angiotensin system (RAS). We tested hypothesis that lacking (DKO mice) would be resistant to proatherogenic NOS inhibition. DKO fed Western diet were immune 23% worsening aortic sinus plaque area seen animals under 12 weeks inhibition with subpressor dose...
Sex hormone-binding globulin (SHBG) is the main transporter of sex hormones in most vertebrates. Low SHBG levels have been linked to increased risk for diabetes and metabolic syndrome. Polymorphisms gene low protein also strongly predicted type 2 diabetes, thus raising possibility that may play a role pathogenesis insulin resistance diabetes.To examine whether expression human mice ameliorate development syndrome response high-fat diet (HFD).Transgene expressing transgene (SHBG+) (N = 10/11;...
Tetrahydrobiopterin (BH4) is an essential co-factor for the biosynthesis of catecholamine-type neurotransmitters and nitric oxide (NO). The expression enzymes catalyzing first two steps BH4 biosynthetic pathway was studied in developing chicken retina by situ hybridization immunocytochemistry. GTP-cyclohydrolase-I (GTP-CH-I) 6-pyruvoyl-tetrahydropterin synthase (PTPS) were already expressed undifferentiated proliferating E7. At stage E11 both photoreceptors, amacrine cells, displaced...
Applied Immunohistochemistry & Molecular Morphology: March 1999 - Volume 7 Issue 1 p 100-101