A5055971713- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Chemotherapy-induced organ toxicity mitigation
- Chemical Reactions and Isotopes
- Safe Handling of Antineoplastic Drugs
- Cancer Genomics and Diagnostics
- Pesticide and Herbicide Environmental Studies
University of Aveiro
2022-2024
Abstract Capecitabine (CAP, prodrug) and 5-fluorouracil (5-FU, its active metabolite) are two of the most prominent cytostatics, for which no clear picture can be drawn regarding potential concentrations effect freshwater biota, with CAP being grouped in least studied cytostatic, whereas 5-FU has been classified as high environmental risk. Accordingly, present work aimed to assess ecotoxicity three species, included a 72-h assay producer Raphidocelis subcapitata ; 96-h invertebrate secondary...
Due to the increasing incidence of cancer, consumption highly toxic oncological drugs is continuously growing. Given current lack efficient technologies remove/treat these in wastewater treatment plants, environmental quality compromised, and aquatic organisms are at risk. To address this critical burden, a new strategy based on supported ionic liquids (SILs) for simultaneous removal oncologic toxicity reduction aqueous samples here proposed. Silica-based SILs functionalized with...
Given the growing number of cancer diseases, new cytostatic drugs are approved daily, often with concomitant development, or refinement some these aimed at decreasing patient discomfort during administration period (e.g., prodrugs). Classified as highly toxic, they represent a major environmental problem that may potentiate disease occurrences. For newer and prodrugs there no (or few) reported effects to aquatic organisms; therefore, their prioritization is constrained. In light points...