A5025379395- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Peripheral Artery Disease Management
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Musculoskeletal Disorders and Rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Chronic Lymphocytic Leukemia Research
- Diagnosis and Treatment of Venous Diseases
- Bone and Joint Diseases
- Health and Medical Studies
- Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Musculoskeletal pain and rehabilitation
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Health, Medicine and Society
- Retinal and Optic Conditions
- Nutritional Studies and Diet
- Healthcare Systems and Practices
- Dermatological and Skeletal Disorders
- Venous Thromboembolism Diagnosis and Management
Ruhr University Bochum
2014-2024
Zimmer Biomet (Germany)
2013-2023
University Hospital Bonn
2023
Klinikum Magdeburg
2022
University Hospital Magdeburg
1998-2022
Praxis für Humangenetik
2005-2021
Orthopädische Praxis
2020-2021
Rheumazentrum Ruhrgebiet
2013-2020
Friedrich-Ebert-Stiftung e.V.
2019
Rheumatology Consultants
2013-2016
Patients with axial spondylarthritis (SpA) who have structural changes in the sacroiliac joints and/or spine been classified as having ankylosing spondylitis (AS), while those without such are now nonradiographic SpA (nr-axSpA). The differentiating features incompletely understood.Data from 100 consecutive patients not treated tumor necrosis factor antagonists were compared clinically and laboratory parameters, spinal radiographs, magnetic resonance imaging (MRI) of spine. Standardized...
Objective This study investigated whether efficacious methotrexate (MTX) treatment has an impact on mortality of patients with severe rheumatoid arthritis (RA). Methods In this prospective, observational, one-center study, RA refractory to other disease-modifying antirheumatic drugs started MTX between 1980 and 1987. Patients were divided into 4 different groups according their response after 1 year (>50% improvement [n = 99], 20–50% 70], no 52], discontinued 35]). After a followup 7.5–15.3...
Rituximab (RTX) has been used successfully for the treatment of severe Jo1 antibody-associated antisynthetase syndrome. The aim this retrospective study was to evaluate effect RTX in syndrome and determine predictive factors response.There were 61 patients with identified; 18 these received RTX. One patient lost followup. remaining 17 30 out 43 who treated conventional immunosuppressive (IS) drugs followed a mean 35 months 84 months, respectively.Polymyositis/dermatomyositis (95%)...
Introduction: With growing age, multiple chronic diseases may result in polypharmacy. Drugs that should be avoided older adults are called potentially inappropriate medications (PIM). Beyond PIM, drug-drug interactions (DDI) known to related adverse drug events. This analysis examines the risk of frequent falling, hospital admission, and death associated with PIM and/or DDI (PIM/DDI) prescription. Materials methods: post hoc used data a subgroup getABI study participants, large cohort...
The threshold for disease activity required to start antitumour necrosis factor (TNF) therapy has been arbitrarily set in patients with axial spondyloarthritis (axSpA) at Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4. How this relates spinal inflammation is unknown.To systematically compare the clinical, laboratory and imaging data of axSpA respect their BASDAI level.A total 100 consecutive who had never treated TNF blockers were included. Laboratory parameters, MRI x-rays...
Objective. NSAIDs are first-line therapy in axial SpA (axSpA). The proportion of patients responding to and differences between AS non-radiographic axSpA (nr-axSpA) this regard have not been studied detail date. aim study was examine the with nr-axSpA according current treatment recommendations. Methods. Consecutive anti-TNF-naïve (n = 50 each) were included if their BASDAI score ⩾4 without having received maximal NSAID doses. In case a 1 week later, another prescribed. For next 3 weeks,...
The Assessments of Spondyloarthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA) have been criticized because insufficient differentiation towards FM. aim this study was to compare the performance currently used in patients diagnosed with axSpA or FM.Patients were prospectively included if FM by treating rheumatologist and evaluated an independent examiner fulfilment (ASAS criteria) and/or (1990 ACR 2010 diagnostic criteria). Patients stratified...
In active early rheumatoid arthritis (RA), glucocorticoids are often used for bridging, due to the delayed action of methotrexate. This study was undertaken compare effect 3 bridging strategies, including high-dose and low-dose prednisolone, on radiographic clinical outcomes.Adult RA patients from 1 rheumatology hospital 23 practices who presented with moderate/high disease activity were randomized (1:1:1) receive 60 mg prednisolone (high-dose [HDP]) or 10 (low-dose [LDP]) daily (tapered 0...
To assess the risk of peripheral artery disease (PAD) in older adults and contribution traditional novel factors to incidence PAD.344 general practitioners (GPs), trained by vascular specialists all over Germany, enrolled 6,880 unselected participants aged 65 years or (getABI study). The onset PAD was determined a regression method course repeated measurements ankle brachial index (ABI) seven years. defined declining linear ABI line reaching 0.9 symptoms.The cumulative 12.9%, corresponding...
Imaging has an essential role in the new spondyloarthritis (SpA) classification criteria for axial but not peripheral manifestations. We evaluated impact of imaging findings identification and treatment decisions patients with (pSpA) controls (non-SpA).Patients pSpA (Assessment SpA international Society criteria, n=30) non-SpA (n=30), aged <45 years, painful heels or knees, were recruited. Conventional radiography, grey-scale ultrasound including power Doppler (US/PDUS) MRI symptomatic areas...
Medications with an unfavorable risk-benefit profile in the elderly, and for which there are safer alternatives, designated as potentially inappropriate medications (PIM). The RIME trial (Reduction of Potentially Inappropriate Medication Elderly) was based on PRISCUS, a list PIM that developed 2010 German pharmaceuticals market. In this trial, it studied whether special training PRISCUS card could lessen undesired drug-drug interactions (DDI) among elderly patients primary care.A...
In some areas of Germany, there is a shortage specialist physicians for patients with inflammatory rheumatic diseases. Delegating certain medical care services to qualified, specialized rheumatological assistants (SRAs) might be an effective way supplement the available capacity care.Patients under stable treatment rheumatoid arthritis (RA) or psoriatic (PsA) were included in this trial, which was designed demonstrate, first step, non-inferiority form involving delegation physicians' tasks...
Some composite measures for determining the treatment effects of disease-modifying antirheumatic drugs on remission and low disease activity (LDA) in rheumatoid arthritis (RA) may produce misleading results if they include an acute phase reactant (APR). To inform choice appropriate measure, we performed a systematic comparison using different measures.We used data generated review biologics RA conducted by Institute Quality Efficiency Health Care from reviews newer Janus kinase (JAK)...
A new conceptual framework has enabled the flexible development of rheumatological patient educational programs for different healthcare settings. On this basis, a 5‑h basic training program patients with rheumatoid arthritis (RA) was developed to be used in specialized centers. Rheumatologists and psychologists were first trained then efficacy evaluated based on causal model education.The externally randomized waiting control group study 249 RA included 3 measurement points. The impact...
In Germany, the care of patients with inflammatory arthritis could be improved. Although specialized rheumatology nurses take over substantial aspects patient care, this hardly occurs in Germany. Thus, aim study is to examine structured nursing consultation practices.
<h3>Background</h3> Both patients with axial spondyloarthritis (axSpA) and fibromyalgia (FM) are suffering from pain. The new ASAS classification criteria for axSpA have been recently challenged by arguing that FM could easily fulfill the clinical arm of criteria, which lead to overdiagnosis wrong treatment decisions. <h3>Objectives</h3> To study similarities differences between using different sets assess severity wide-spread pain in both diseases. <h3>Methods</h3> In this prospective...
Zusammenfassung Qualitätsstandards (QS) sind messbare Konstrukte, die helfen sollen, Versorgungslücken quantitativ zu erfassen, um langfristig Versorgungsqualität verbessern. Die Assessment of SpondyloArthritis International Society (ASAS) hat kürzlich erstmals internationale QS für das Management von Patient*innen mit axialer Spondyloarthritis (axSpA) konsentiert und veröffentlicht. Deutsche Gesellschaft Rheumatologie (DGRh) daraufhin beschlossen, diese Standards durch eine Gruppe...