A5069648144- Advanced Causal Inference Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Alzheimer's disease research and treatments
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Cystic Fibrosis Research Advances
- Vaccine Coverage and Hesitancy
- Pharmacovigilance and Adverse Drug Reactions
- Health and Medical Studies
- Colorectal Cancer Treatments and Studies
- Tuberculosis Research and Epidemiology
- Neurological disorders and treatments
- Rheumatoid Arthritis Research and Therapies
- Parkinson's Disease Mechanisms and Treatments
- Pediatric health and respiratory diseases
- Dementia and Cognitive Impairment Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Statistical Methods in Clinical Trials
- Data-Driven Disease Surveillance
- Autoimmune and Inflammatory Disorders Research
Ruhr University Bochum
2020-2025
Zimmer Biomet (Germany)
2021-2025
Zimmer Biomet (United States)
2024
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2022
University of Lübeck
2021
Universität Ulm
2005
Treatment specific survival curves are an important tool to illustrate the treatment effect in studies with time‐to‐event outcomes. In non‐randomized studies, unadjusted estimates can lead biased depictions due confounding. Multiple methods adjust for confounders exist. However, it is currently unclear which method most appropriate situation. Our goal compare forms of inverse probability weighting, G‐Formula, propensity score matching, empirical likelihood estimation and augmented estimators...
Abstract Background Complete mesocolic excision (CME) for right colonic cancer is a more complex operation than standard hemicolectomy but evidence to support its routine use still limited. This prospective multicentre study evaluated the effect of CME on long-term survival in colorectal centres Germany (RESECTAT trial). The primary hypothesis was that 5-year disease-free would be higher after non-CME surgery. A secondary there improved patients with mesenteric area greater 15 000 mm2....
Visualization is a key aspect of communicating the results any study aiming to estimate causal effects. In studies with time-to-event outcomes, most popular visualization approach depicting survival curves stratified by variable interest. This cannot be used when interest continuous. Simple workarounds, such as categorizing continuous covariate and plotting for each category, can result in misleading depictions main Instead, we propose new graphic, area plot, directly depict probability over...
Abstract Background We evaluated Aβ misfolding in combination with 42/40 ratio as a prognostic tool for future clinical progression to mild cognitive impairment (MCI) or dementia due Alzheimer’s disease (AD) individuals subjective decline (SCD). Methods Baseline plasma samples ( n = 203) from SCD subjects the SCIENCe project and Amsterdam Dementia Cohort (age 61 ± 9 years; 57% male, mean follow-up time 2.7 years) were analyzed using immuno-infrared-sensor technology. Within 6 years of...
Aim This article presents the study protocol of a retrospective cohort designed to compare effectiveness herpes zoster, and influenza vaccines in individuals with multiple sclerosis (MS), chronic inflammatory bowel diseases (IBD), or rheumatic (CIRD) without these diseases, using claims data one largest population based health insurances Germany. Background Individuals autoimmune such as MS, IBD, CIRD are more susceptible vaccine preventable infectious due disease itself, presence...
Abstract Purpose In contrast to adults, immune protection against SARS-CoV-2 in children and adolescents with natural or hybrid immunity is still poorly understood. The aim of this study was analyze different compartments age groups whether humoral reactions correlate a cellular response. Methods 72 preceding infection were recruited. 37 vaccinated an RNA vaccine (BNT162b2). Humoral analyzed 3–26 months (median 10 months) after by measuring Spike protein (S), nucleocapsid (NCP), neutralizing...
Abstract Misfolding and aggregation of alpha-synuclein (αSyn) play a key role in the pathophysiology Parkinson’s disease (PD). Despite considerable advances diagnostics, an early differential diagnosis PD still represents major challenge. We innovated immuno-infrared sensor (iRS) platform for measuring αSyn misfolding. analyzed cerebrospinal fluid (CSF) from two cohorts comprising cases, atypical Parkinsonian disorders, controls. obtained AUC 0.90 ( n = 134, 95% CI 0.85–0.96) separating...
Abstract In multi-analyst studies, several analysts use the same data to independently investigate identical research questions. Multi-analyst studies have been conducted mainly in psychology, social sciences, and neuroscience, but rarely epidemiology. Sixteen analyst groups (24 researchers) with backgrounds statistics, mathematics, epidemiology were asked perform an analysis on influence of marital status (never married versus cohabiting married) cardiovascular outcomes. They from Survey...
PCD is a genetic disease leading to decline in pulmonary function. There only little knowledge of factors determining the long-term outcome. Especially adherence has not been addressed yet although being an independent risk factor for increased loss lung capacity other chronic respiratory diseases.Assessing impact bacterial airway colonization and on function patients with PCD.Data parameters like forced expiratory volume first second (FEV1, Z-score) clearance index (LCI2,5% ) were collected...
In some areas of Germany, there is a shortage specialist physicians for patients with inflammatory rheumatic diseases. Delegating certain medical care services to qualified, specialized rheumatological assistants (SRAs) might be an effective way supplement the available capacity care.Patients under stable treatment rheumatoid arthritis (RA) or psoriatic (PsA) were included in this trial, which was designed demonstrate, first step, non-inferiority form involving delegation physicians' tasks...
Nerve cross-sectional area (CSA) is not constant over the human lifespan. The relationship between an increasing CSA and age has been described as a linear positive correlation, but few studies have found decrease in nerve size with older age. aim of present study was to analyze development healthy population from early childhood old using high-resolution ultrasound.
In recent times, large language models (LLMs) have made significant strides in generating computer code, blurring the lines between code created by humans and produced artificial intelligence (AI). As these technologies evolve rapidly, it is crucial to explore how they influence generation, especially given risk of misuse areas such as higher education. The present paper explores this issue using advanced classification techniques differentiate written generated ChatGPT, a type LLM. We...
An effective tool for establishing concordant end-of-life (EOL) care in patients with cancer is advance planning (ACP). However, various barriers, including psychological obstacles, hamper the access to ACP. Therefore, a new conceptual model combining psycho-oncological approach structured ACP was developed. The effectiveness and efficiency of this concept collaborative (col-ACP) evaluated present randomised controlled trial palliative cancer.
Domestic robots, such as vacuum cleaners or lawn mowers, are mostly based on a low-cost design to make them affordable for the consumer. This often results in robots being equipped with only simple sensors, in-/outside area detectors mowers. Intelligent navigation and planning strategies, however, usually require additional sensors like LiDAR cameras time of flight sensors. Thus, there is lack intelligent approaches complete coverage workspace under consideration minimal sensing...
Abstract Background Colon cancer (CC) is a disease of elderly patients (pts.) with median age 73 years (yrs.). Lack data about the effects adjuvant chemotherapy (ACT) caused by underrepresentation this clinically relevant cohort in interventional trials. We analyzed real‐world from German CPP registry regard to possible benefit ACT (70+ yrs.) versus younger pts. (50 <70 taking cause‐specific deaths into account. Methods effect and on overall survival (OS) death stage III using Cox...
An amendment to this paper has been published and can be accessed via the original article.
Zusammenfassung Einleitung Die Delegation ärztlicher Leistungen an rheumatologische Fachassistent:innen (RFA) hat sich in der Evaluation des Forschungsprojektes „StärkeR“ als sicher und effektiv erwiesen. Im Nachgang wurden die Erfahrungen beteiligten RFA Rheumatolog:innen mit im Rahmen eines Meinungsforschungsprojekts erfragt diskutiert. Methoden Zum Ende Projekts teilnehmenden (mittleres Alter 45 Jahre, 100 % weiblich, durchschnittlich 11 Jahre Berufserfahrung) 54 32 21 Berufserfahrung),...
The possibility of balancing career and family is meanwhile a central concern for most physicians when choosing job. aim this study was to identify current barriers opportunities physician education planning.
Understanding the mutational landscape of colon cancer (CC) is crucial for targeted therapy development. Microsatellite instability (MSI-H), rat sarcoma (RAS), and B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations (MT) are pivotal markers. Further investigation into clinicopathological features RAS BRAF MT in microsatellite stable (MSS) MSI-H tumors warranted.